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Synthesis, antitumor activity and QSAR studies of some 4-aminomethylidene derivatives of edaravone
dc.creator | Marković, Violeta | |
dc.creator | Erić, Slavica | |
dc.creator | Juranić, Zorica | |
dc.creator | Stanojković, Tatjana | |
dc.creator | Joksović, Ljubinka | |
dc.creator | Ranković, Branislav | |
dc.creator | Kosanić, Marijana | |
dc.creator | Joksović, Milan D. | |
dc.date.accessioned | 2019-09-02T11:24:02Z | |
dc.date.available | 2019-09-02T11:24:02Z | |
dc.date.issued | 2011 | |
dc.identifier.issn | 0045-2068 | |
dc.identifier.uri | https://farfar.pharmacy.bg.ac.rs/handle/123456789/1500 | |
dc.description.abstract | A series of aminomethylidene derivatives obtained from 4-formyledaravone were synthesized and characterized by IR, NMR and elemental analysis. All the compounds were screened for their antitumor activity. The compound containing 5-phenylpyrazole moiety (3q) exhibited remarkable antitumor activity in in vitro assays, especially against human breast cancer MDA-MB-361 and MDA-MB-453 cell lines. The most important whole-molecule descriptors for antitumor activity on MDA-MB-453 cells belong to the group of quantum-chemical descriptors. | en |
dc.publisher | Academic Press Inc Elsevier Science, San Diego | |
dc.relation | info:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/172016/RS// | |
dc.rights | restrictedAccess | |
dc.source | Bioorganic Chemistry | |
dc.subject | Edaravone derivatives | en |
dc.subject | Antitumor activity | en |
dc.subject | QSAR studies | en |
dc.title | Synthesis, antitumor activity and QSAR studies of some 4-aminomethylidene derivatives of edaravone | en |
dc.type | article | |
dc.rights.license | ARR | |
dcterms.abstract | Станојковић, Татјана; Јоксовић, Љубинка; Ерић, Славица; Јуранић, Зорица; Марковић, Виолета; Јоксовић, Милан Д.; Косанић, Маријана; Ранковић, Бранислав; | |
dc.citation.volume | 39 | |
dc.citation.issue | 1-3 | |
dc.citation.spage | 18 | |
dc.citation.epage | 27 | |
dc.citation.other | 39(1-3): 18-27 | |
dc.citation.rank | M23 | |
dc.identifier.wos | 000307423100003 | |
dc.identifier.doi | 10.1016/j.bioorg.2010.10.003 | |
dc.identifier.pmid | 21078519 | |
dc.identifier.scopus | 2-s2.0-78751647459 | |
dc.type.version | publishedVersion |