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dc.creatorMarković, Bojan
dc.creatorVladimirov, Sote
dc.creatorČudina, Olivera
dc.creatorSavić, Vladimir
dc.creatorKarljiković-Rajić, Katarina
dc.date.accessioned2019-09-02T11:24:03Z
dc.date.available2019-09-02T11:24:03Z
dc.date.issued2011
dc.identifier.issn1082-6076
dc.identifier.urihttp://farfar.pharmacy.bg.ac.rs/handle/123456789/1501
dc.description.abstractIn this study the solvolysis of novel fluocinolone acetonide 21-(2'-phenoxypropionate) in comparison with fluocinonide was analyzed in order to evaluate this process as an in vitro model for prodrug activation. The solvolysis was performed in ethanol: water (90: 10 v/v) mixture using the excess of NaHCO3. The solvolytic mixtures of those esters with different lipophilicity were assayed by proposed RP-HPLC method using isocratic elution with methanol: water (75: 25 v/v); flow rate 1 mL min(-1), and detection at 238 nm. Solvolytic rate constants (at 25 degrees C) for novel prodrug fluocinolone acetonide 21-(2'-phenoxypropionate) (0.0434 h(-1)) and fluocinonide (0.0593 h(-1)) have been compared. This in vitro model of solvolysis and corresponding rate constants are in good correlation with our preliminary data of anti-inflammatory potencies of those prodrugs. Limits of detection, important for the initial stage of solvolysis, were experimentally determined with values of 4.10 mu M and 0.24 mu M for fluocinolone acetonide 21-(2'-phenoxypropionate) and fluocinonide, respectively.en
dc.publisherTaylor & Francis Inc, Philadelphia
dc.relationinfo:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/172041/RS//
dc.rightsrestrictedAccess
dc.sourceJournal of Liquid Chromatography & Related Technologies
dc.subjectfluocinolone acetonide estersen
dc.subjectfluocinonideen
dc.subjectprodrugen
dc.subjectRP-HPLCen
dc.subjectsolvolysisen
dc.subjectsolvolytic rate constantsen
dc.titleHPLC evaluation of solvolysis of a novel ester fluocinolone acetonide 21-(2'-phenoxypropionate) in comparison with fluocinonideen
dc.typearticle
dc.rights.licenseARR
dcterms.abstractСавић, Владимир; Марковић, Бојан; Владимиров, Соте; Чудина, Оливера; Карљиковић-Рајић, Катарина;
dc.citation.volume34
dc.citation.issue19
dc.citation.spage2271
dc.citation.epage2285
dc.citation.other34(19): 2271-2285
dc.citation.rankM23
dc.identifier.wos000299376000003
dc.identifier.doi10.1080/10826076.2011.587223
dc.identifier.scopus2-s2.0-84855872884
dc.identifier.rcubconv_2577
dc.type.versionpublishedVersion


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