dc.creator | Marković, Bojan | |
dc.creator | Vladimirov, Sote | |
dc.creator | Čudina, Olivera | |
dc.creator | Savić, Vladimir | |
dc.creator | Karljiković-Rajić, Katarina | |
dc.date.accessioned | 2019-09-02T11:24:03Z | |
dc.date.available | 2019-09-02T11:24:03Z | |
dc.date.issued | 2011 | |
dc.identifier.issn | 1082-6076 | |
dc.identifier.uri | https://farfar.pharmacy.bg.ac.rs/handle/123456789/1501 | |
dc.description.abstract | In this study the solvolysis of novel fluocinolone acetonide 21-(2'-phenoxypropionate) in comparison with fluocinonide was analyzed in order to evaluate this process as an in vitro model for prodrug activation. The solvolysis was performed in ethanol: water (90: 10 v/v) mixture using the excess of NaHCO3. The solvolytic mixtures of those esters with different lipophilicity were assayed by proposed RP-HPLC method using isocratic elution with methanol: water (75: 25 v/v); flow rate 1 mL min(-1), and detection at 238 nm. Solvolytic rate constants (at 25 degrees C) for novel prodrug fluocinolone acetonide 21-(2'-phenoxypropionate) (0.0434 h(-1)) and fluocinonide (0.0593 h(-1)) have been compared. This in vitro model of solvolysis and corresponding rate constants are in good correlation with our preliminary data of anti-inflammatory potencies of those prodrugs. Limits of detection, important for the initial stage of solvolysis, were experimentally determined with values of 4.10 mu M and 0.24 mu M for fluocinolone acetonide 21-(2'-phenoxypropionate) and fluocinonide, respectively. | en |
dc.publisher | Taylor & Francis Inc, Philadelphia | |
dc.relation | info:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/172041/RS// | |
dc.rights | restrictedAccess | |
dc.source | Journal of Liquid Chromatography & Related Technologies | |
dc.subject | fluocinolone acetonide esters | en |
dc.subject | fluocinonide | en |
dc.subject | prodrug | en |
dc.subject | RP-HPLC | en |
dc.subject | solvolysis | en |
dc.subject | solvolytic rate constants | en |
dc.title | HPLC evaluation of solvolysis of a novel ester fluocinolone acetonide 21-(2'-phenoxypropionate) in comparison with fluocinonide | en |
dc.type | article | |
dc.rights.license | ARR | |
dcterms.abstract | Савић, Владимир; Марковић, Бојан; Владимиров, Соте; Чудина, Оливера; Карљиковић-Рајић, Катарина; | |
dc.citation.volume | 34 | |
dc.citation.issue | 19 | |
dc.citation.spage | 2271 | |
dc.citation.epage | 2285 | |
dc.citation.other | 34(19): 2271-2285 | |
dc.citation.rank | M23 | |
dc.identifier.wos | 000299376000003 | |
dc.identifier.doi | 10.1080/10826076.2011.587223 | |
dc.identifier.scopus | 2-s2.0-84855872884 | |
dc.type.version | publishedVersion | |