Our previous experiments showed that excessive oral Mg intake has beneficial effects in chronic Pb poisoning, inducing decrease of Pb body burden and its increased elimination via urine. The aim of this work was to investigate and to compare the effect of Mg on urinary Pb elimination with the effect of calcium-disodium edetate (CaNa(2)EDTA) - chelating agent currently used in therapy of chronic Pb intoxication. Besides, under the same experimental conditions, biochemical parameters protoporphyrin IX (ppIX), zinc protoporphyrin (Znpp) and delta-aminolevulinic acid (ALA) were determined. Experiments were carried out on rabbits preciously intoxicated for 4 weeks with 20 mg Pb/kg b.w. per day. After the period of intoxication, one group of animals was given per os, for 28 days, 40 mg Mg/kg, the other one was i.v. treated for 7 days with 15 mg CaNa(2)EDTA/kg (therapeutic doses), while the third one [rabbits without therapy] served as a control. During the period of detoxication, lead was de...termined in blood and urine samples, and ppIX and Znpp were determined in blood and ALA in urine. Results suggest that oral treatment with magnesium, although inducing later Pb elimination than EDTA, has even better effect on investigated biochemical parameters than chelating therapy.
TY - JOUR
AU - Soldatović, Danilo
AU - Vujanović, Dragana
AU - Matović, Vesna
AU - Bulat, Zorica
PY - 1997
UR - https://farfar.pharmacy.bg.ac.rs/handle/123456789/151
AB - Our previous experiments showed that excessive oral Mg intake has beneficial effects in chronic Pb poisoning, inducing decrease of Pb body burden and its increased elimination via urine. The aim of this work was to investigate and to compare the effect of Mg on urinary Pb elimination with the effect of calcium-disodium edetate (CaNa(2)EDTA) - chelating agent currently used in therapy of chronic Pb intoxication. Besides, under the same experimental conditions, biochemical parameters protoporphyrin IX (ppIX), zinc protoporphyrin (Znpp) and delta-aminolevulinic acid (ALA) were determined. Experiments were carried out on rabbits preciously intoxicated for 4 weeks with 20 mg Pb/kg b.w. per day. After the period of intoxication, one group of animals was given per os, for 28 days, 40 mg Mg/kg, the other one was i.v. treated for 7 days with 15 mg CaNa(2)EDTA/kg (therapeutic doses), while the third one [rabbits without therapy] served as a control. During the period of detoxication, lead was determined in blood and urine samples, and ppIX and Znpp were determined in blood and ALA in urine. Results suggest that oral treatment with magnesium, although inducing later Pb elimination than EDTA, has even better effect on investigated biochemical parameters than chelating therapy.
PB - John Libbey Eurotext
T2 - Magnesium Research
T1 - Compared effects of high oral Mg supplements and of EDTA chelating agent on chronic lead intoxication in rabbits
VL - 10
IS - 2
SP - 127
EP - 133
UR - https://hdl.handle.net/21.15107/rcub_farfar_151
ER -
@article{
author = "Soldatović, Danilo and Vujanović, Dragana and Matović, Vesna and Bulat, Zorica",
year = "1997",
abstract = "Our previous experiments showed that excessive oral Mg intake has beneficial effects in chronic Pb poisoning, inducing decrease of Pb body burden and its increased elimination via urine. The aim of this work was to investigate and to compare the effect of Mg on urinary Pb elimination with the effect of calcium-disodium edetate (CaNa(2)EDTA) - chelating agent currently used in therapy of chronic Pb intoxication. Besides, under the same experimental conditions, biochemical parameters protoporphyrin IX (ppIX), zinc protoporphyrin (Znpp) and delta-aminolevulinic acid (ALA) were determined. Experiments were carried out on rabbits preciously intoxicated for 4 weeks with 20 mg Pb/kg b.w. per day. After the period of intoxication, one group of animals was given per os, for 28 days, 40 mg Mg/kg, the other one was i.v. treated for 7 days with 15 mg CaNa(2)EDTA/kg (therapeutic doses), while the third one [rabbits without therapy] served as a control. During the period of detoxication, lead was determined in blood and urine samples, and ppIX and Znpp were determined in blood and ALA in urine. Results suggest that oral treatment with magnesium, although inducing later Pb elimination than EDTA, has even better effect on investigated biochemical parameters than chelating therapy.",
publisher = "John Libbey Eurotext",
journal = "Magnesium Research",
title = "Compared effects of high oral Mg supplements and of EDTA chelating agent on chronic lead intoxication in rabbits",
volume = "10",
number = "2",
pages = "127-133",
url = "https://hdl.handle.net/21.15107/rcub_farfar_151"
}
Soldatović, D., Vujanović, D., Matović, V.,& Bulat, Z.. (1997). Compared effects of high oral Mg supplements and of EDTA chelating agent on chronic lead intoxication in rabbits. in Magnesium Research
John Libbey Eurotext., 10(2), 127-133.
https://hdl.handle.net/21.15107/rcub_farfar_151
Soldatović D, Vujanović D, Matović V, Bulat Z. Compared effects of high oral Mg supplements and of EDTA chelating agent on chronic lead intoxication in rabbits. in Magnesium Research. 1997;10(2):127-133.
https://hdl.handle.net/21.15107/rcub_farfar_151 .
Soldatović, Danilo, Vujanović, Dragana, Matović, Vesna, Bulat, Zorica, "Compared effects of high oral Mg supplements and of EDTA chelating agent on chronic lead intoxication in rabbits" in Magnesium Research, 10, no. 2 (1997):127-133,
https://hdl.handle.net/21.15107/rcub_farfar_151 .
