Cellular and Nerve Fibre Catecholaminergic Thymic Network: Steroid Hormone Dependent Activity
Abstract
The thymus plays a critical role in establishing and maintaining the peripheral T-cell pool. It does so by providing a microenvironment within which T-cell precursors differentiate and undergo selection processes to create a functional population of major histocompatibility complex-restricted, self-tolerant T cells. These cells are central to adaptive immunity. Thymic T-cell development is influenced by locally produced soluble factors and cell-to-cell interactions, as well as by sympathetic noradrenergic and endocrine system signalling. Thymic lymphoid and non-lymphoid cells have been shown not only to express beta- and alpha(1)-adrenoceptors (ARs), but also to synthesize catecholamines (CAs). Thus, it is suggested that CAs influence T-cell development via both neurocrine/endocrine and autocrine/paracrine action, and that they serve as immunotransmitters between thymocytes and nerves. CAs acting at multiple sites along the thymocyte developmental route affect T-cell generation not onl...y numerically, but also qualitatively. Thymic CA level and synthesis, as well as AR expression exhibit sex steroid-mediated sexual dimorphism. Moreover, the influence of CAs on T-cell development exhibits glucocorticoid-dependent plasticity. This review summarizes recent findings in this field and our current understanding of complex and multifaceted neuroendocrine-immune communications at thymic level.
Keywords:
Thymus / Catecholamines / Adrenoceptors / Sexual dimorphism / GlucocorticoidsSource:
Physiological Research, 2011, 60, SUPPL.1Publisher:
- Acad Sciences Czech Republic, Inst Physiology, Prague 4
Projects:
Collections
Institution
PharmacyTY - JOUR AU - Leposavić, Gordana AU - Pilipović, Ivan AU - Perišić, M. PY - 2011 UR - http://farfar.pharmacy.bg.ac.rs/handle/123456789/1510 AB - The thymus plays a critical role in establishing and maintaining the peripheral T-cell pool. It does so by providing a microenvironment within which T-cell precursors differentiate and undergo selection processes to create a functional population of major histocompatibility complex-restricted, self-tolerant T cells. These cells are central to adaptive immunity. Thymic T-cell development is influenced by locally produced soluble factors and cell-to-cell interactions, as well as by sympathetic noradrenergic and endocrine system signalling. Thymic lymphoid and non-lymphoid cells have been shown not only to express beta- and alpha(1)-adrenoceptors (ARs), but also to synthesize catecholamines (CAs). Thus, it is suggested that CAs influence T-cell development via both neurocrine/endocrine and autocrine/paracrine action, and that they serve as immunotransmitters between thymocytes and nerves. CAs acting at multiple sites along the thymocyte developmental route affect T-cell generation not only numerically, but also qualitatively. Thymic CA level and synthesis, as well as AR expression exhibit sex steroid-mediated sexual dimorphism. Moreover, the influence of CAs on T-cell development exhibits glucocorticoid-dependent plasticity. This review summarizes recent findings in this field and our current understanding of complex and multifaceted neuroendocrine-immune communications at thymic level. PB - Acad Sciences Czech Republic, Inst Physiology, Prague 4 T2 - Physiological Research T1 - Cellular and Nerve Fibre Catecholaminergic Thymic Network: Steroid Hormone Dependent Activity VL - 60 IS - SUPPL.1 ER -
@article{ author = "Leposavić, Gordana and Pilipović, Ivan and Perišić, M.", year = "2011", url = "http://farfar.pharmacy.bg.ac.rs/handle/123456789/1510", abstract = "The thymus plays a critical role in establishing and maintaining the peripheral T-cell pool. It does so by providing a microenvironment within which T-cell precursors differentiate and undergo selection processes to create a functional population of major histocompatibility complex-restricted, self-tolerant T cells. These cells are central to adaptive immunity. Thymic T-cell development is influenced by locally produced soluble factors and cell-to-cell interactions, as well as by sympathetic noradrenergic and endocrine system signalling. Thymic lymphoid and non-lymphoid cells have been shown not only to express beta- and alpha(1)-adrenoceptors (ARs), but also to synthesize catecholamines (CAs). Thus, it is suggested that CAs influence T-cell development via both neurocrine/endocrine and autocrine/paracrine action, and that they serve as immunotransmitters between thymocytes and nerves. CAs acting at multiple sites along the thymocyte developmental route affect T-cell generation not only numerically, but also qualitatively. Thymic CA level and synthesis, as well as AR expression exhibit sex steroid-mediated sexual dimorphism. Moreover, the influence of CAs on T-cell development exhibits glucocorticoid-dependent plasticity. This review summarizes recent findings in this field and our current understanding of complex and multifaceted neuroendocrine-immune communications at thymic level.", publisher = "Acad Sciences Czech Republic, Inst Physiology, Prague 4", journal = "Physiological Research", title = "Cellular and Nerve Fibre Catecholaminergic Thymic Network: Steroid Hormone Dependent Activity", volume = "60", number = "SUPPL.1" }
Leposavić G, Pilipović I, Perišić M. Cellular and Nerve Fibre Catecholaminergic Thymic Network: Steroid Hormone Dependent Activity. Physiological Research. 2011;60(SUPPL.1)
Leposavić, G., Pilipović, I.,& Perišić, M. (2011). Cellular and Nerve Fibre Catecholaminergic Thymic Network: Steroid Hormone Dependent Activity. Physiological ResearchAcad Sciences Czech Republic, Inst Physiology, Prague 4., 60(SUPPL.1).
Leposavić Gordana, Pilipović Ivan, Perišić M., "Cellular and Nerve Fibre Catecholaminergic Thymic Network: Steroid Hormone Dependent Activity" 60, no. SUPPL.1 (2011)