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Cellular and Nerve Fibre Catecholaminergic Thymic Network: Steroid Hormone Dependent Activity

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Authors
Leposavić, Gordana
Pilipović, Ivan
Perišić, M.
Article (Published version)
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Abstract
The thymus plays a critical role in establishing and maintaining the peripheral T-cell pool. It does so by providing a microenvironment within which T-cell precursors differentiate and undergo selection processes to create a functional population of major histocompatibility complex-restricted, self-tolerant T cells. These cells are central to adaptive immunity. Thymic T-cell development is influenced by locally produced soluble factors and cell-to-cell interactions, as well as by sympathetic noradrenergic and endocrine system signalling. Thymic lymphoid and non-lymphoid cells have been shown not only to express beta- and alpha(1)-adrenoceptors (ARs), but also to synthesize catecholamines (CAs). Thus, it is suggested that CAs influence T-cell development via both neurocrine/endocrine and autocrine/paracrine action, and that they serve as immunotransmitters between thymocytes and nerves. CAs acting at multiple sites along the thymocyte developmental route affect T-cell generation not onl...y numerically, but also qualitatively. Thymic CA level and synthesis, as well as AR expression exhibit sex steroid-mediated sexual dimorphism. Moreover, the influence of CAs on T-cell development exhibits glucocorticoid-dependent plasticity. This review summarizes recent findings in this field and our current understanding of complex and multifaceted neuroendocrine-immune communications at thymic level.

Keywords:
Thymus / Catecholamines / Adrenoceptors / Sexual dimorphism / Glucocorticoids
Source:
Physiological Research, 2011, 60, SUPPL.1
Publisher:
  • Acad Sciences Czech Republic, Inst Physiology, Prague 4
Funding / projects:
  • Neuroendokrina modulacija imunskog odgovora: uloga simpato-adrenomedularnog sistema (RS-145049)

ISSN: 0862-8408

PubMed: 21777027

WoS: 000296334200007

Scopus: 2-s2.0-84856594269
[ Google Scholar ]
16
15
Handle
https://hdl.handle.net/21.15107/rcub_farfar_1510
URI
https://farfar.pharmacy.bg.ac.rs/handle/123456789/1510
Collections
  • Radovi istraživača / Researchers’ publications
Institution/Community
Pharmacy
TY  - JOUR
AU  - Leposavić, Gordana
AU  - Pilipović, Ivan
AU  - Perišić, M.
PY  - 2011
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/1510
AB  - The thymus plays a critical role in establishing and maintaining the peripheral T-cell pool. It does so by providing a microenvironment within which T-cell precursors differentiate and undergo selection processes to create a functional population of major histocompatibility complex-restricted, self-tolerant T cells. These cells are central to adaptive immunity. Thymic T-cell development is influenced by locally produced soluble factors and cell-to-cell interactions, as well as by sympathetic noradrenergic and endocrine system signalling. Thymic lymphoid and non-lymphoid cells have been shown not only to express beta- and alpha(1)-adrenoceptors (ARs), but also to synthesize catecholamines (CAs). Thus, it is suggested that CAs influence T-cell development via both neurocrine/endocrine and autocrine/paracrine action, and that they serve as immunotransmitters between thymocytes and nerves. CAs acting at multiple sites along the thymocyte developmental route affect T-cell generation not only numerically, but also qualitatively. Thymic CA level and synthesis, as well as AR expression exhibit sex steroid-mediated sexual dimorphism. Moreover, the influence of CAs on T-cell development exhibits glucocorticoid-dependent plasticity. This review summarizes recent findings in this field and our current understanding of complex and multifaceted neuroendocrine-immune communications at thymic level.
PB  - Acad Sciences Czech Republic, Inst Physiology, Prague 4
T2  - Physiological Research
T1  - Cellular and Nerve Fibre Catecholaminergic Thymic Network: Steroid Hormone Dependent Activity
VL  - 60
IS  - SUPPL.1
UR  - https://hdl.handle.net/21.15107/rcub_farfar_1510
ER  - 
@article{
author = "Leposavić, Gordana and Pilipović, Ivan and Perišić, M.",
year = "2011",
abstract = "The thymus plays a critical role in establishing and maintaining the peripheral T-cell pool. It does so by providing a microenvironment within which T-cell precursors differentiate and undergo selection processes to create a functional population of major histocompatibility complex-restricted, self-tolerant T cells. These cells are central to adaptive immunity. Thymic T-cell development is influenced by locally produced soluble factors and cell-to-cell interactions, as well as by sympathetic noradrenergic and endocrine system signalling. Thymic lymphoid and non-lymphoid cells have been shown not only to express beta- and alpha(1)-adrenoceptors (ARs), but also to synthesize catecholamines (CAs). Thus, it is suggested that CAs influence T-cell development via both neurocrine/endocrine and autocrine/paracrine action, and that they serve as immunotransmitters between thymocytes and nerves. CAs acting at multiple sites along the thymocyte developmental route affect T-cell generation not only numerically, but also qualitatively. Thymic CA level and synthesis, as well as AR expression exhibit sex steroid-mediated sexual dimorphism. Moreover, the influence of CAs on T-cell development exhibits glucocorticoid-dependent plasticity. This review summarizes recent findings in this field and our current understanding of complex and multifaceted neuroendocrine-immune communications at thymic level.",
publisher = "Acad Sciences Czech Republic, Inst Physiology, Prague 4",
journal = "Physiological Research",
title = "Cellular and Nerve Fibre Catecholaminergic Thymic Network: Steroid Hormone Dependent Activity",
volume = "60",
number = "SUPPL.1",
url = "https://hdl.handle.net/21.15107/rcub_farfar_1510"
}
Leposavić, G., Pilipović, I.,& Perišić, M.. (2011). Cellular and Nerve Fibre Catecholaminergic Thymic Network: Steroid Hormone Dependent Activity. in Physiological Research
Acad Sciences Czech Republic, Inst Physiology, Prague 4., 60(SUPPL.1).
https://hdl.handle.net/21.15107/rcub_farfar_1510
Leposavić G, Pilipović I, Perišić M. Cellular and Nerve Fibre Catecholaminergic Thymic Network: Steroid Hormone Dependent Activity. in Physiological Research. 2011;60(SUPPL.1).
https://hdl.handle.net/21.15107/rcub_farfar_1510 .
Leposavić, Gordana, Pilipović, Ivan, Perišić, M., "Cellular and Nerve Fibre Catecholaminergic Thymic Network: Steroid Hormone Dependent Activity" in Physiological Research, 60, no. SUPPL.1 (2011),
https://hdl.handle.net/21.15107/rcub_farfar_1510 .

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