dc.creator | Leposavić, Gordana | |
dc.creator | Pilipović, Ivan | |
dc.creator | Perišić, M. | |
dc.date.accessioned | 2019-09-02T11:24:15Z | |
dc.date.available | 2019-09-02T11:24:15Z | |
dc.date.issued | 2011 | |
dc.identifier.issn | 0862-8408 | |
dc.identifier.uri | https://farfar.pharmacy.bg.ac.rs/handle/123456789/1510 | |
dc.description.abstract | The thymus plays a critical role in establishing and maintaining the peripheral T-cell pool. It does so by providing a microenvironment within which T-cell precursors differentiate and undergo selection processes to create a functional population of major histocompatibility complex-restricted, self-tolerant T cells. These cells are central to adaptive immunity. Thymic T-cell development is influenced by locally produced soluble factors and cell-to-cell interactions, as well as by sympathetic noradrenergic and endocrine system signalling. Thymic lymphoid and non-lymphoid cells have been shown not only to express beta- and alpha(1)-adrenoceptors (ARs), but also to synthesize catecholamines (CAs). Thus, it is suggested that CAs influence T-cell development via both neurocrine/endocrine and autocrine/paracrine action, and that they serve as immunotransmitters between thymocytes and nerves. CAs acting at multiple sites along the thymocyte developmental route affect T-cell generation not only numerically, but also qualitatively. Thymic CA level and synthesis, as well as AR expression exhibit sex steroid-mediated sexual dimorphism. Moreover, the influence of CAs on T-cell development exhibits glucocorticoid-dependent plasticity. This review summarizes recent findings in this field and our current understanding of complex and multifaceted neuroendocrine-immune communications at thymic level. | en |
dc.publisher | Acad Sciences Czech Republic, Inst Physiology, Prague 4 | |
dc.relation | info:eu-repo/grantAgreement/MESTD/MPN2006-2010/145049/RS// | |
dc.rights | openAccess | |
dc.rights.uri | https://creativecommons.org/licenses/by-nc/4.0/ | |
dc.source | Physiological Research | |
dc.subject | Thymus | en |
dc.subject | Catecholamines | en |
dc.subject | Adrenoceptors | en |
dc.subject | Sexual dimorphism | en |
dc.subject | Glucocorticoids | en |
dc.title | Cellular and Nerve Fibre Catecholaminergic Thymic Network: Steroid Hormone Dependent Activity | en |
dc.type | article | |
dc.rights.license | BY-NC | |
dcterms.abstract | Лепосавић, Гордана; Перишић, М.; Пилиповић, Иван; | |
dc.citation.volume | 60 | |
dc.citation.issue | SUPPL.1 | |
dc.citation.other | 60: - | |
dc.citation.rank | M23 | |
dc.identifier.wos | 000296334200007 | |
dc.identifier.pmid | 21777027 | |
dc.identifier.scopus | 2-s2.0-84856594269 | |
dc.identifier.rcub | https://hdl.handle.net/21.15107/rcub_farfar_1510 | |
dc.type.version | publishedVersion | |