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Cellular and Nerve Fibre Catecholaminergic Thymic Network: Steroid Hormone Dependent Activity

Нема приказа
Аутори
Leposavić, Gordana
Pilipović, Ivan
Perišić, M.
Чланак у часопису (Објављена верзија)
Метаподаци
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Апстракт
The thymus plays a critical role in establishing and maintaining the peripheral T-cell pool. It does so by providing a microenvironment within which T-cell precursors differentiate and undergo selection processes to create a functional population of major histocompatibility complex-restricted, self-tolerant T cells. These cells are central to adaptive immunity. Thymic T-cell development is influenced by locally produced soluble factors and cell-to-cell interactions, as well as by sympathetic noradrenergic and endocrine system signalling. Thymic lymphoid and non-lymphoid cells have been shown not only to express beta- and alpha(1)-adrenoceptors (ARs), but also to synthesize catecholamines (CAs). Thus, it is suggested that CAs influence T-cell development via both neurocrine/endocrine and autocrine/paracrine action, and that they serve as immunotransmitters between thymocytes and nerves. CAs acting at multiple sites along the thymocyte developmental route affect T-cell generation not onl...y numerically, but also qualitatively. Thymic CA level and synthesis, as well as AR expression exhibit sex steroid-mediated sexual dimorphism. Moreover, the influence of CAs on T-cell development exhibits glucocorticoid-dependent plasticity. This review summarizes recent findings in this field and our current understanding of complex and multifaceted neuroendocrine-immune communications at thymic level.

Кључне речи:
Thymus / Catecholamines / Adrenoceptors / Sexual dimorphism / Glucocorticoids
Извор:
Physiological Research, 2011, 60, SUPPL.1
Издавач:
  • Acad Sciences Czech Republic, Inst Physiology, Prague 4
Пројекти:
  • Неуроендокрина модулација имунског одговора: улога симпато-адреномедуларног система (RS-145049)

ISSN: 0862-8408

PubMed: 21777027

WoS: 000296334200007

Scopus: 2-s2.0-84856594269
[ Google Scholar ]
13
13
URI
http://farfar.pharmacy.bg.ac.rs/handle/123456789/1510
Колекције
  • Radovi istraživača / Researchers’ publications
Институција
Pharmacy

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