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dc.creatorLeposavić, Gordana
dc.creatorPilipović, Ivan
dc.creatorPerišić, M.
dc.date.accessioned2019-09-02T11:24:15Z
dc.date.available2019-09-02T11:24:15Z
dc.date.issued2011
dc.identifier.issn0862-8408
dc.identifier.urihttp://farfar.pharmacy.bg.ac.rs/handle/123456789/1510
dc.description.abstractThe thymus plays a critical role in establishing and maintaining the peripheral T-cell pool. It does so by providing a microenvironment within which T-cell precursors differentiate and undergo selection processes to create a functional population of major histocompatibility complex-restricted, self-tolerant T cells. These cells are central to adaptive immunity. Thymic T-cell development is influenced by locally produced soluble factors and cell-to-cell interactions, as well as by sympathetic noradrenergic and endocrine system signalling. Thymic lymphoid and non-lymphoid cells have been shown not only to express beta- and alpha(1)-adrenoceptors (ARs), but also to synthesize catecholamines (CAs). Thus, it is suggested that CAs influence T-cell development via both neurocrine/endocrine and autocrine/paracrine action, and that they serve as immunotransmitters between thymocytes and nerves. CAs acting at multiple sites along the thymocyte developmental route affect T-cell generation not only numerically, but also qualitatively. Thymic CA level and synthesis, as well as AR expression exhibit sex steroid-mediated sexual dimorphism. Moreover, the influence of CAs on T-cell development exhibits glucocorticoid-dependent plasticity. This review summarizes recent findings in this field and our current understanding of complex and multifaceted neuroendocrine-immune communications at thymic level.en
dc.publisherAcad Sciences Czech Republic, Inst Physiology, Prague 4
dc.relationinfo:eu-repo/grantAgreement/MESTD/MPN2006-2010/145049/RS//
dc.rightsopenAccess
dc.sourcePhysiological Research
dc.subjectThymusen
dc.subjectCatecholaminesen
dc.subjectAdrenoceptorsen
dc.subjectSexual dimorphismen
dc.subjectGlucocorticoidsen
dc.titleCellular and Nerve Fibre Catecholaminergic Thymic Network: Steroid Hormone Dependent Activityen
dc.typearticle
dc.rights.licenseBY-NC
dcterms.abstractЛепосавић, Гордана; Перишић, М.; Пилиповић, Иван;
dc.citation.volume60
dc.citation.issueSUPPL.1
dc.citation.other60: -
dc.citation.rankM23
dc.identifier.wos000296334200007
dc.identifier.pmid21777027
dc.identifier.scopus2-s2.0-84856594269
dc.identifier.rcubconv_2544
dc.type.versionpublishedVersion


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