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Neonatal androgenization affects the efficiency of beta-adrenoceptor-mediated modulation of thymopoiesis

Authorized Users Only
2011
Authors
Radojević, Katarina
Kosec, Duško
Perišić, Milica
Pilipović, Ivan
Vidić-Danković, Biljana
Leposavić, Gordana
Article (Published version)
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Abstract
We tested the hypothesis that neonatal androgenization affects the efficacy of beta-adrenoceptor (beta-AR)-mediated fine tuning of thymopoiesis in adult female rats by modulating the thymic noradrenaline (NA) level and/or beta-AR expression. In adult rats administered with 1000 mu g testosterone enanthate at postnatal day 2 a higher density of catecholamine (CA)-synthesizing thymic cells, including thymocytes, and a rise in their CA content was found. In addition, in these animals increased thymic noradrenergic nerve fiber fluorescence intensity, reflecting their increased CA content, was detected. These changes were followed by an increase in thymic NA concentration. The rise in thymic NA content in thymic nerve fibers and cells was associated with changes in the expression of mRNA for enzymes controling pivotal steps in NA biosynthesis (tyrosine hydroxylase, dopamine-beta-hydroxylase) and inactivation (monoamine oxidase). In contrast, the thymic level of beta(2)-AR mRNA on a per cell... basis and the receptor surface density on thymocytes was reduced in testosterone-treated (TT) rats. As a consequence, 14-day-long treatment with propranolol, a beta-AR blocker, was ineffective in modulating T-cell differentiation/maturation in TT rats. In conclusion, the study indicates the importance of the neonatal sex steroid milieu for shaping the immunomodulatory capacity of the thymic NA/beta-AR signaling system in adult rats.

Keywords:
Neonatal androgenization / Thymus / Noradrenaline / beta-Adrenoceptors
Source:
Journal of Neuroimmunology, 2011, 239, 1-2, 68-79
Publisher:
  • Elsevier Science BV, Amsterdam
Funding / projects:
  • Immune system plasticity during aging: Immunomodulatory capacity of oestrogens (RS-175050)

DOI: 10.1016/j.jneuroim.2011.08.020

ISSN: 0165-5728

PubMed: 21940054

WoS: 000297395700009

Scopus: 2-s2.0-80054889026
[ Google Scholar ]
7
7
URI
https://farfar.pharmacy.bg.ac.rs/handle/123456789/1511
Collections
  • Radovi istraživača / Researchers’ publications
Institution/Community
Pharmacy
TY  - JOUR
AU  - Radojević, Katarina
AU  - Kosec, Duško
AU  - Perišić, Milica
AU  - Pilipović, Ivan
AU  - Vidić-Danković, Biljana
AU  - Leposavić, Gordana
PY  - 2011
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/1511
AB  - We tested the hypothesis that neonatal androgenization affects the efficacy of beta-adrenoceptor (beta-AR)-mediated fine tuning of thymopoiesis in adult female rats by modulating the thymic noradrenaline (NA) level and/or beta-AR expression. In adult rats administered with 1000 mu g testosterone enanthate at postnatal day 2 a higher density of catecholamine (CA)-synthesizing thymic cells, including thymocytes, and a rise in their CA content was found. In addition, in these animals increased thymic noradrenergic nerve fiber fluorescence intensity, reflecting their increased CA content, was detected. These changes were followed by an increase in thymic NA concentration. The rise in thymic NA content in thymic nerve fibers and cells was associated with changes in the expression of mRNA for enzymes controling pivotal steps in NA biosynthesis (tyrosine hydroxylase, dopamine-beta-hydroxylase) and inactivation (monoamine oxidase). In contrast, the thymic level of beta(2)-AR mRNA on a per cell basis and the receptor surface density on thymocytes was reduced in testosterone-treated (TT) rats. As a consequence, 14-day-long treatment with propranolol, a beta-AR blocker, was ineffective in modulating T-cell differentiation/maturation in TT rats. In conclusion, the study indicates the importance of the neonatal sex steroid milieu for shaping the immunomodulatory capacity of the thymic NA/beta-AR signaling system in adult rats.
PB  - Elsevier Science BV, Amsterdam
T2  - Journal of Neuroimmunology
T1  - Neonatal androgenization affects the efficiency of beta-adrenoceptor-mediated modulation of thymopoiesis
VL  - 239
IS  - 1-2
SP  - 68
EP  - 79
DO  - 10.1016/j.jneuroim.2011.08.020
ER  - 
@article{
author = "Radojević, Katarina and Kosec, Duško and Perišić, Milica and Pilipović, Ivan and Vidić-Danković, Biljana and Leposavić, Gordana",
year = "2011",
abstract = "We tested the hypothesis that neonatal androgenization affects the efficacy of beta-adrenoceptor (beta-AR)-mediated fine tuning of thymopoiesis in adult female rats by modulating the thymic noradrenaline (NA) level and/or beta-AR expression. In adult rats administered with 1000 mu g testosterone enanthate at postnatal day 2 a higher density of catecholamine (CA)-synthesizing thymic cells, including thymocytes, and a rise in their CA content was found. In addition, in these animals increased thymic noradrenergic nerve fiber fluorescence intensity, reflecting their increased CA content, was detected. These changes were followed by an increase in thymic NA concentration. The rise in thymic NA content in thymic nerve fibers and cells was associated with changes in the expression of mRNA for enzymes controling pivotal steps in NA biosynthesis (tyrosine hydroxylase, dopamine-beta-hydroxylase) and inactivation (monoamine oxidase). In contrast, the thymic level of beta(2)-AR mRNA on a per cell basis and the receptor surface density on thymocytes was reduced in testosterone-treated (TT) rats. As a consequence, 14-day-long treatment with propranolol, a beta-AR blocker, was ineffective in modulating T-cell differentiation/maturation in TT rats. In conclusion, the study indicates the importance of the neonatal sex steroid milieu for shaping the immunomodulatory capacity of the thymic NA/beta-AR signaling system in adult rats.",
publisher = "Elsevier Science BV, Amsterdam",
journal = "Journal of Neuroimmunology",
title = "Neonatal androgenization affects the efficiency of beta-adrenoceptor-mediated modulation of thymopoiesis",
volume = "239",
number = "1-2",
pages = "68-79",
doi = "10.1016/j.jneuroim.2011.08.020"
}
Radojević, K., Kosec, D., Perišić, M., Pilipović, I., Vidić-Danković, B.,& Leposavić, G.. (2011). Neonatal androgenization affects the efficiency of beta-adrenoceptor-mediated modulation of thymopoiesis. in Journal of Neuroimmunology
Elsevier Science BV, Amsterdam., 239(1-2), 68-79.
https://doi.org/10.1016/j.jneuroim.2011.08.020
Radojević K, Kosec D, Perišić M, Pilipović I, Vidić-Danković B, Leposavić G. Neonatal androgenization affects the efficiency of beta-adrenoceptor-mediated modulation of thymopoiesis. in Journal of Neuroimmunology. 2011;239(1-2):68-79.
doi:10.1016/j.jneuroim.2011.08.020 .
Radojević, Katarina, Kosec, Duško, Perišić, Milica, Pilipović, Ivan, Vidić-Danković, Biljana, Leposavić, Gordana, "Neonatal androgenization affects the efficiency of beta-adrenoceptor-mediated modulation of thymopoiesis" in Journal of Neuroimmunology, 239, no. 1-2 (2011):68-79,
https://doi.org/10.1016/j.jneuroim.2011.08.020 . .

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