Background: Oxidative stress and inflammation play an important role in the pathogenesis of chronic: obstructive pulmonary disease (COPD). Objective: Pulmonary function, oxidative stress parameters and inflammatory markers were measured in 74 patients with severe COPD exacerbation and 41 healthy subjects. In patients all parameters were assessed at two time points: Firstly, one day after admission and secondly, after 7-10 days when they were clinically stable enough to be discharged. Patients were divided in two groups according the presence of ischemic heart disease (IHD): IHD positive (IHD+) patients and IHD negative (IHD-) patients. Methods and Results: During hospitalisation O(2)(center dot-), malondialdehyde (MDA), advanced oxidation protein products (AOPP) and total oxidant status (TOS) increased and were higher at discharge compared with admission and the control group. Superoxide dismutase (SOD) activity was significantly lower in COPD patients at both time points compared with... the control group. Total antioxidant status (TAS) was significantly lower and the prooxidant-antioxidant balance (PAB) was higher at both time points in COPD patients compared with the control group. High sensitive C-reactive protein (hsCRP) and also the neutrophil count were significantly higher at admission compared with discharge. Paraoxonase 1 (PON1) enzymatic activities in COPD patients did not differ compared with the control group. IHD+ COPD patients had significantly lower PON1 activity but higher PAB levels and hsCRP concentrations, compared with IHD- COPD patients. Conclusion: The oxidant/antioxidant imbalance was significantly pronounced in patients with COPD exacerbation for at least 24 hours following their admission and when they were clinically stable enough to be discharged. Increased oxidative stress, elevated systemic inflammation and decreased antioxidant defence were common in end-stage disease and particularly COPD patients with ischemic heart disease.
TY - JOUR
AU - Stanojković, Ivana
AU - Kotur-Stevuljević, Jelena
AU - Milenković, Branislava
AU - Spasić, Slavica
AU - Vujić, Tatjana
AU - Stefanović, Aleksandra
AU - Ilić, Aleksandra
AU - Ivanišević, Jasmina
PY - 2011
UR - http://farfar.pharmacy.bg.ac.rs/handle/123456789/1514
AB - Background: Oxidative stress and inflammation play an important role in the pathogenesis of chronic: obstructive pulmonary disease (COPD). Objective: Pulmonary function, oxidative stress parameters and inflammatory markers were measured in 74 patients with severe COPD exacerbation and 41 healthy subjects. In patients all parameters were assessed at two time points: Firstly, one day after admission and secondly, after 7-10 days when they were clinically stable enough to be discharged. Patients were divided in two groups according the presence of ischemic heart disease (IHD): IHD positive (IHD+) patients and IHD negative (IHD-) patients. Methods and Results: During hospitalisation O(2)(center dot-), malondialdehyde (MDA), advanced oxidation protein products (AOPP) and total oxidant status (TOS) increased and were higher at discharge compared with admission and the control group. Superoxide dismutase (SOD) activity was significantly lower in COPD patients at both time points compared with the control group. Total antioxidant status (TAS) was significantly lower and the prooxidant-antioxidant balance (PAB) was higher at both time points in COPD patients compared with the control group. High sensitive C-reactive protein (hsCRP) and also the neutrophil count were significantly higher at admission compared with discharge. Paraoxonase 1 (PON1) enzymatic activities in COPD patients did not differ compared with the control group. IHD+ COPD patients had significantly lower PON1 activity but higher PAB levels and hsCRP concentrations, compared with IHD- COPD patients. Conclusion: The oxidant/antioxidant imbalance was significantly pronounced in patients with COPD exacerbation for at least 24 hours following their admission and when they were clinically stable enough to be discharged. Increased oxidative stress, elevated systemic inflammation and decreased antioxidant defence were common in end-stage disease and particularly COPD patients with ischemic heart disease.
PB - W B Saunders Co Ltd, London
T2 - Revue Roumaine de Chimie
T1 - Pulmonary function, oxidative stress and inflammatory markers in severe COPD exacerbation
VL - 105
DO - 10.1016/S0954-6111(11)70008-7
UR - conv_2559
ER -
@article{
author = "Stanojković, Ivana and Kotur-Stevuljević, Jelena and Milenković, Branislava and Spasić, Slavica and Vujić, Tatjana and Stefanović, Aleksandra and Ilić, Aleksandra and Ivanišević, Jasmina",
year = "2011",
abstract = "Background: Oxidative stress and inflammation play an important role in the pathogenesis of chronic: obstructive pulmonary disease (COPD). Objective: Pulmonary function, oxidative stress parameters and inflammatory markers were measured in 74 patients with severe COPD exacerbation and 41 healthy subjects. In patients all parameters were assessed at two time points: Firstly, one day after admission and secondly, after 7-10 days when they were clinically stable enough to be discharged. Patients were divided in two groups according the presence of ischemic heart disease (IHD): IHD positive (IHD+) patients and IHD negative (IHD-) patients. Methods and Results: During hospitalisation O(2)(center dot-), malondialdehyde (MDA), advanced oxidation protein products (AOPP) and total oxidant status (TOS) increased and were higher at discharge compared with admission and the control group. Superoxide dismutase (SOD) activity was significantly lower in COPD patients at both time points compared with the control group. Total antioxidant status (TAS) was significantly lower and the prooxidant-antioxidant balance (PAB) was higher at both time points in COPD patients compared with the control group. High sensitive C-reactive protein (hsCRP) and also the neutrophil count were significantly higher at admission compared with discharge. Paraoxonase 1 (PON1) enzymatic activities in COPD patients did not differ compared with the control group. IHD+ COPD patients had significantly lower PON1 activity but higher PAB levels and hsCRP concentrations, compared with IHD- COPD patients. Conclusion: The oxidant/antioxidant imbalance was significantly pronounced in patients with COPD exacerbation for at least 24 hours following their admission and when they were clinically stable enough to be discharged. Increased oxidative stress, elevated systemic inflammation and decreased antioxidant defence were common in end-stage disease and particularly COPD patients with ischemic heart disease.",
publisher = "W B Saunders Co Ltd, London",
journal = "Revue Roumaine de Chimie",
title = "Pulmonary function, oxidative stress and inflammatory markers in severe COPD exacerbation",
volume = "105",
doi = "10.1016/S0954-6111(11)70008-7",
url = "conv_2559"
}
Stanojković, I., Kotur-Stevuljević, J., Milenković, B., Spasić, S., Vujić, T., Stefanović, A., Ilić, A.,& Ivanišević, J.. (2011). Pulmonary function, oxidative stress and inflammatory markers in severe COPD exacerbation. in Revue Roumaine de Chimie
W B Saunders Co Ltd, London., 105.
https://doi.org/10.1016/S0954-6111(11)70008-7
conv_2559
Stanojković I, Kotur-Stevuljević J, Milenković B, Spasić S, Vujić T, Stefanović A, Ilić A, Ivanišević J. Pulmonary function, oxidative stress and inflammatory markers in severe COPD exacerbation. in Revue Roumaine de Chimie. 2011;105.
doi:10.1016/S0954-6111(11)70008-7
conv_2559 .
Stanojković, Ivana, Kotur-Stevuljević, Jelena, Milenković, Branislava, Spasić, Slavica, Vujić, Tatjana, Stefanović, Aleksandra, Ilić, Aleksandra, Ivanišević, Jasmina, "Pulmonary function, oxidative stress and inflammatory markers in severe COPD exacerbation" in Revue Roumaine de Chimie, 105 (2011),
https://doi.org/10.1016/S0954-6111(11)70008-7 .,
conv_2559 .
