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dc.creatorStanojković, Ivana
dc.creatorKotur-Stevuljević, Jelena
dc.creatorMilenković, Branislava
dc.creatorSpasić, Slavica
dc.creatorVujić, Tatjana
dc.creatorStefanović, Aleksandra
dc.creatorIlić, Aleksandra
dc.creatorIvanišević, Jasmina
dc.date.accessioned2019-09-02T11:24:22Z
dc.date.available2019-09-02T11:24:22Z
dc.date.issued2011
dc.identifier.issn0954-6111
dc.identifier.urihttp://farfar.pharmacy.bg.ac.rs/handle/123456789/1514
dc.description.abstractBackground: Oxidative stress and inflammation play an important role in the pathogenesis of chronic: obstructive pulmonary disease (COPD). Objective: Pulmonary function, oxidative stress parameters and inflammatory markers were measured in 74 patients with severe COPD exacerbation and 41 healthy subjects. In patients all parameters were assessed at two time points: Firstly, one day after admission and secondly, after 7-10 days when they were clinically stable enough to be discharged. Patients were divided in two groups according the presence of ischemic heart disease (IHD): IHD positive (IHD+) patients and IHD negative (IHD-) patients. Methods and Results: During hospitalisation O(2)(center dot-), malondialdehyde (MDA), advanced oxidation protein products (AOPP) and total oxidant status (TOS) increased and were higher at discharge compared with admission and the control group. Superoxide dismutase (SOD) activity was significantly lower in COPD patients at both time points compared with the control group. Total antioxidant status (TAS) was significantly lower and the prooxidant-antioxidant balance (PAB) was higher at both time points in COPD patients compared with the control group. High sensitive C-reactive protein (hsCRP) and also the neutrophil count were significantly higher at admission compared with discharge. Paraoxonase 1 (PON1) enzymatic activities in COPD patients did not differ compared with the control group. IHD+ COPD patients had significantly lower PON1 activity but higher PAB levels and hsCRP concentrations, compared with IHD- COPD patients. Conclusion: The oxidant/antioxidant imbalance was significantly pronounced in patients with COPD exacerbation for at least 24 hours following their admission and when they were clinically stable enough to be discharged. Increased oxidative stress, elevated systemic inflammation and decreased antioxidant defence were common in end-stage disease and particularly COPD patients with ischemic heart disease.en
dc.publisherW B Saunders Co Ltd, London
dc.relationinfo:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/175035/RS//
dc.rightsopenAccess
dc.sourceRevue Roumaine de Chimie
dc.subjectCOPDen
dc.subjectInflammationen
dc.subjectOxidative stressen
dc.subjectParaoxonase 1en
dc.subjectProoxidant-antioxidant balanceen
dc.titlePulmonary function, oxidative stress and inflammatory markers in severe COPD exacerbationen
dc.typearticle
dc.rights.licenseARR
dcterms.abstractСпасић, Славица; Иванишевић, Јасмина; Вујић, Татјана; Илић, Aлександра; Стефановић, Aлександра; Станојковић, Ивана; Миленковић, Бранислава; Котур-Стевуљевић, Јелена;
dc.citation.volume105
dc.citation.other105: -
dc.citation.rankM22
dc.identifier.wos000297779800007
dc.identifier.doi10.1016/S0954-6111(11)70008-7
dc.identifier.pmid22015083
dc.identifier.scopus2-s2.0-80054997454
dc.identifier.fulltexthttp://farfar.pharmacy.bg.ac.rs//bitstream/id/376/1512.pdf
dc.identifier.rcubconv_2559
dc.type.versionpublishedVersion


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