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Evaluation of Single-Point Sampling Strategies for the Estimation of Moclobemide Exposure in Depressive Patients

Само за регистроване кориснике
2011
Аутори
Rakić-Ignjatović, Anita
Miljković, Branislava
Todorović, Dejan
Timotijević, Ivana
Pokrajac, Milena
Чланак у часопису (Објављена верзија)
Метаподаци
Приказ свих података о документу
Апстракт
Because moclobemide pharmacokinetics vary considerably among individuals, monitoring of plasma concentrations lends insight into its pharmacokinetic behavior and enhances its rational use in clinical practice. The aim of this study was to evaluate whether single concentration-time points could adequately predict moclobemide systemic exposure. Pharmacokinetic data (full 7-point pharmacokinetic profiles), obtained from 21 depressive inpatients receiving moclobemide (150 mg 3 times daily), were randomly split into development (n = 18) and validation (n = 16) sets. Correlations between the single concentration-time points and the area under the concentration-time curve within a 6-hour dosing interval at steady-state (AUC(0-6)) were assessed by linear regression analyses. The predictive performance of single-point sampling strategies was evaluated in the validation set by mean prediction error, mean absolute error, and root mean square error. Plasma concentrations in the absorption phase yi...elded unsatisfactory predictions of moclobemide AUC(0-6). The best estimation of AUC(0-6) was achieved from concentrations at 4 and 6 hours following dosing. As the most reliable surrogate for moclobemide systemic exposure, concentrations at 4 and 6 hours should be used instead of predose trough concentrations as an indicator of between-patient variability and a guide for dose adjustments in specific clinical situations.

Кључне речи:
Moclobemide / single-point sampling strategies / systemic exposure / predictive performance / depressive patients
Извор:
Journal of Clinical Pharmacology, 2011, 51, 5, 661-671
Издавач:
  • Wiley, Hoboken
Финансирање / пројекти:
  • Експериментална и клиничко-фармаколошка истраживања механизма дејства и интеракција лекова у нервном и кардиоваскуларном систему (RS-145001)

DOI: 10.1177/0091270010372105

ISSN: 0091-2700

PubMed: 20495135

WoS: 000289942400005

Scopus: 2-s2.0-79955541937
[ Google Scholar ]
7
6
URI
https://farfar.pharmacy.bg.ac.rs/handle/123456789/1518
Колекције
  • Radovi istraživača / Researchers’ publications
Институција/група
Pharmacy
TY  - JOUR
AU  - Rakić-Ignjatović, Anita
AU  - Miljković, Branislava
AU  - Todorović, Dejan
AU  - Timotijević, Ivana
AU  - Pokrajac, Milena
PY  - 2011
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/1518
AB  - Because moclobemide pharmacokinetics vary considerably among individuals, monitoring of plasma concentrations lends insight into its pharmacokinetic behavior and enhances its rational use in clinical practice. The aim of this study was to evaluate whether single concentration-time points could adequately predict moclobemide systemic exposure. Pharmacokinetic data (full 7-point pharmacokinetic profiles), obtained from 21 depressive inpatients receiving moclobemide (150 mg 3 times daily), were randomly split into development (n = 18) and validation (n = 16) sets. Correlations between the single concentration-time points and the area under the concentration-time curve within a 6-hour dosing interval at steady-state (AUC(0-6)) were assessed by linear regression analyses. The predictive performance of single-point sampling strategies was evaluated in the validation set by mean prediction error, mean absolute error, and root mean square error. Plasma concentrations in the absorption phase yielded unsatisfactory predictions of moclobemide AUC(0-6). The best estimation of AUC(0-6) was achieved from concentrations at 4 and 6 hours following dosing. As the most reliable surrogate for moclobemide systemic exposure, concentrations at 4 and 6 hours should be used instead of predose trough concentrations as an indicator of between-patient variability and a guide for dose adjustments in specific clinical situations.
PB  - Wiley, Hoboken
T2  - Journal of Clinical Pharmacology
T1  - Evaluation of Single-Point Sampling Strategies for the Estimation of Moclobemide Exposure in Depressive Patients
VL  - 51
IS  - 5
SP  - 661
EP  - 671
DO  - 10.1177/0091270010372105
ER  - 
@article{
author = "Rakić-Ignjatović, Anita and Miljković, Branislava and Todorović, Dejan and Timotijević, Ivana and Pokrajac, Milena",
year = "2011",
abstract = "Because moclobemide pharmacokinetics vary considerably among individuals, monitoring of plasma concentrations lends insight into its pharmacokinetic behavior and enhances its rational use in clinical practice. The aim of this study was to evaluate whether single concentration-time points could adequately predict moclobemide systemic exposure. Pharmacokinetic data (full 7-point pharmacokinetic profiles), obtained from 21 depressive inpatients receiving moclobemide (150 mg 3 times daily), were randomly split into development (n = 18) and validation (n = 16) sets. Correlations between the single concentration-time points and the area under the concentration-time curve within a 6-hour dosing interval at steady-state (AUC(0-6)) were assessed by linear regression analyses. The predictive performance of single-point sampling strategies was evaluated in the validation set by mean prediction error, mean absolute error, and root mean square error. Plasma concentrations in the absorption phase yielded unsatisfactory predictions of moclobemide AUC(0-6). The best estimation of AUC(0-6) was achieved from concentrations at 4 and 6 hours following dosing. As the most reliable surrogate for moclobemide systemic exposure, concentrations at 4 and 6 hours should be used instead of predose trough concentrations as an indicator of between-patient variability and a guide for dose adjustments in specific clinical situations.",
publisher = "Wiley, Hoboken",
journal = "Journal of Clinical Pharmacology",
title = "Evaluation of Single-Point Sampling Strategies for the Estimation of Moclobemide Exposure in Depressive Patients",
volume = "51",
number = "5",
pages = "661-671",
doi = "10.1177/0091270010372105"
}
Rakić-Ignjatović, A., Miljković, B., Todorović, D., Timotijević, I.,& Pokrajac, M.. (2011). Evaluation of Single-Point Sampling Strategies for the Estimation of Moclobemide Exposure in Depressive Patients. in Journal of Clinical Pharmacology
Wiley, Hoboken., 51(5), 661-671.
https://doi.org/10.1177/0091270010372105
Rakić-Ignjatović A, Miljković B, Todorović D, Timotijević I, Pokrajac M. Evaluation of Single-Point Sampling Strategies for the Estimation of Moclobemide Exposure in Depressive Patients. in Journal of Clinical Pharmacology. 2011;51(5):661-671.
doi:10.1177/0091270010372105 .
Rakić-Ignjatović, Anita, Miljković, Branislava, Todorović, Dejan, Timotijević, Ivana, Pokrajac, Milena, "Evaluation of Single-Point Sampling Strategies for the Estimation of Moclobemide Exposure in Depressive Patients" in Journal of Clinical Pharmacology, 51, no. 5 (2011):661-671,
https://doi.org/10.1177/0091270010372105 . .

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