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dc.creatorRakić-Ignjatović, Anita
dc.creatorMiljković, Branislava
dc.creatorTodorović, Dejan
dc.creatorTimotijević, Ivana
dc.creatorPokrajac, Milena
dc.date.accessioned2019-09-02T11:24:28Z
dc.date.available2019-09-02T11:24:28Z
dc.date.issued2011
dc.identifier.issn0091-2700
dc.identifier.urihttp://farfar.pharmacy.bg.ac.rs/handle/123456789/1518
dc.description.abstractBecause moclobemide pharmacokinetics vary considerably among individuals, monitoring of plasma concentrations lends insight into its pharmacokinetic behavior and enhances its rational use in clinical practice. The aim of this study was to evaluate whether single concentration-time points could adequately predict moclobemide systemic exposure. Pharmacokinetic data (full 7-point pharmacokinetic profiles), obtained from 21 depressive inpatients receiving moclobemide (150 mg 3 times daily), were randomly split into development (n = 18) and validation (n = 16) sets. Correlations between the single concentration-time points and the area under the concentration-time curve within a 6-hour dosing interval at steady-state (AUC(0-6)) were assessed by linear regression analyses. The predictive performance of single-point sampling strategies was evaluated in the validation set by mean prediction error, mean absolute error, and root mean square error. Plasma concentrations in the absorption phase yielded unsatisfactory predictions of moclobemide AUC(0-6). The best estimation of AUC(0-6) was achieved from concentrations at 4 and 6 hours following dosing. As the most reliable surrogate for moclobemide systemic exposure, concentrations at 4 and 6 hours should be used instead of predose trough concentrations as an indicator of between-patient variability and a guide for dose adjustments in specific clinical situations.en
dc.publisherWiley, Hoboken
dc.relationinfo:eu-repo/grantAgreement/MESTD/MPN2006-2010/145001/RS//
dc.rightsrestrictedAccess
dc.sourceJournal of Clinical Pharmacology
dc.subjectMoclobemideen
dc.subjectsingle-point sampling strategiesen
dc.subjectsystemic exposureen
dc.subjectpredictive performanceen
dc.subjectdepressive patientsen
dc.titleEvaluation of Single-Point Sampling Strategies for the Estimation of Moclobemide Exposure in Depressive Patientsen
dc.typearticle
dc.rights.licenseARR
dcterms.abstractТодоровић, Дејан; Покрајац, Милена; Миљковић, Бранислава; Ракић-Игњатовић, Aнита; Тимотијевић, Ивана;
dc.citation.volume51
dc.citation.issue5
dc.citation.spage661
dc.citation.epage671
dc.citation.other51(5): 661-671
dc.citation.rankM22
dc.identifier.wos000289942400005
dc.identifier.doi10.1177/0091270010372105
dc.identifier.pmid20495135
dc.identifier.scopus2-s2.0-79955541937
dc.identifier.rcubconv_2418
dc.type.versionpublishedVersion


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