Compared effects of high oral Mg supplements and of EDTA chelating agent on chronic lead intoxication in rabbits
Abstract
Our previous experiments showed that excessive oral Mg intake has beneficial effects in chronic Pb poisoning, inducing decrease of Pb body burden and its increased elimination via urine. The aim of this work was to investigate and to compare the effect of Mg on urinary Pb elimination with the effect of calcium-disodium edetate (CaNa(2)EDTA) - chelating agent currently used in therapy of chronic Pb intoxication. Besides, under the same experimental conditions, biochemical parameters protoporphyrin IX (ppIX), zinc protoporphyrin (Znpp) and delta-aminolevulinic acid (ALA) were determined. Experiments were carried out on rabbits preciously intoxicated for 4 weeks with 20 mg Pb/kg b.w. per day. After the period of intoxication, one group of animals was given per os, for 28 days, 40 mg Mg/kg, the other one was i.v. treated for 7 days with 15 mg CaNa(2)EDTA/kg (therapeutic doses), while the third one [rabbits without therapy] served as a control. During the period of detoxication, lead was de...termined in blood and urine samples, and ppIX and Znpp were determined in blood and ALA in urine. Results suggest that oral treatment with magnesium, although inducing later Pb elimination than EDTA, has even better effect on investigated biochemical parameters than chelating therapy.
Keywords:
Blood / Calcium-disodium edetate / Lead intoxication / Magnesium / Protoporphyrin IX / Rabbits / Urine / Zinc protoporphyrin / δ-aminolevulinic acidSource:
Magnesium Research, 1997, 10, 2, 127-133Publisher:
- John Libbey Eurotext
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Institution/Community
PharmacyTY - JOUR AU - Soldatović, Danilo AU - Vujanović, Dragana AU - Matović, Vesna AU - Bulat, Zorica PY - 1997 UR - https://farfar.pharmacy.bg.ac.rs/handle/123456789/151 AB - Our previous experiments showed that excessive oral Mg intake has beneficial effects in chronic Pb poisoning, inducing decrease of Pb body burden and its increased elimination via urine. The aim of this work was to investigate and to compare the effect of Mg on urinary Pb elimination with the effect of calcium-disodium edetate (CaNa(2)EDTA) - chelating agent currently used in therapy of chronic Pb intoxication. Besides, under the same experimental conditions, biochemical parameters protoporphyrin IX (ppIX), zinc protoporphyrin (Znpp) and delta-aminolevulinic acid (ALA) were determined. Experiments were carried out on rabbits preciously intoxicated for 4 weeks with 20 mg Pb/kg b.w. per day. After the period of intoxication, one group of animals was given per os, for 28 days, 40 mg Mg/kg, the other one was i.v. treated for 7 days with 15 mg CaNa(2)EDTA/kg (therapeutic doses), while the third one [rabbits without therapy] served as a control. During the period of detoxication, lead was determined in blood and urine samples, and ppIX and Znpp were determined in blood and ALA in urine. Results suggest that oral treatment with magnesium, although inducing later Pb elimination than EDTA, has even better effect on investigated biochemical parameters than chelating therapy. PB - John Libbey Eurotext T2 - Magnesium Research T1 - Compared effects of high oral Mg supplements and of EDTA chelating agent on chronic lead intoxication in rabbits VL - 10 IS - 2 SP - 127 EP - 133 UR - https://hdl.handle.net/21.15107/rcub_farfar_151 ER -
@article{ author = "Soldatović, Danilo and Vujanović, Dragana and Matović, Vesna and Bulat, Zorica", year = "1997", abstract = "Our previous experiments showed that excessive oral Mg intake has beneficial effects in chronic Pb poisoning, inducing decrease of Pb body burden and its increased elimination via urine. The aim of this work was to investigate and to compare the effect of Mg on urinary Pb elimination with the effect of calcium-disodium edetate (CaNa(2)EDTA) - chelating agent currently used in therapy of chronic Pb intoxication. Besides, under the same experimental conditions, biochemical parameters protoporphyrin IX (ppIX), zinc protoporphyrin (Znpp) and delta-aminolevulinic acid (ALA) were determined. Experiments were carried out on rabbits preciously intoxicated for 4 weeks with 20 mg Pb/kg b.w. per day. After the period of intoxication, one group of animals was given per os, for 28 days, 40 mg Mg/kg, the other one was i.v. treated for 7 days with 15 mg CaNa(2)EDTA/kg (therapeutic doses), while the third one [rabbits without therapy] served as a control. During the period of detoxication, lead was determined in blood and urine samples, and ppIX and Znpp were determined in blood and ALA in urine. Results suggest that oral treatment with magnesium, although inducing later Pb elimination than EDTA, has even better effect on investigated biochemical parameters than chelating therapy.", publisher = "John Libbey Eurotext", journal = "Magnesium Research", title = "Compared effects of high oral Mg supplements and of EDTA chelating agent on chronic lead intoxication in rabbits", volume = "10", number = "2", pages = "127-133", url = "https://hdl.handle.net/21.15107/rcub_farfar_151" }
Soldatović, D., Vujanović, D., Matović, V.,& Bulat, Z.. (1997). Compared effects of high oral Mg supplements and of EDTA chelating agent on chronic lead intoxication in rabbits. in Magnesium Research John Libbey Eurotext., 10(2), 127-133. https://hdl.handle.net/21.15107/rcub_farfar_151
Soldatović D, Vujanović D, Matović V, Bulat Z. Compared effects of high oral Mg supplements and of EDTA chelating agent on chronic lead intoxication in rabbits. in Magnesium Research. 1997;10(2):127-133. https://hdl.handle.net/21.15107/rcub_farfar_151 .
Soldatović, Danilo, Vujanović, Dragana, Matović, Vesna, Bulat, Zorica, "Compared effects of high oral Mg supplements and of EDTA chelating agent on chronic lead intoxication in rabbits" in Magnesium Research, 10, no. 2 (1997):127-133, https://hdl.handle.net/21.15107/rcub_farfar_151 .