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dc.creatorMarković, Bojan
dc.creatorDobričić, Vladimir
dc.creatorVladimirov, Sote
dc.creatorČudina, Olivera
dc.creatorSavić, Vladimir
dc.creatorKarljiković-Rajić, Katarina
dc.date.accessioned2019-09-02T11:24:35Z
dc.date.available2019-09-02T11:24:35Z
dc.date.issued2011
dc.identifier.issn1420-3049
dc.identifier.urihttps://farfar.pharmacy.bg.ac.rs/handle/123456789/1524
dc.description.abstractIn this study the solvolysis of newly synthesized fluocinolone acetonide C-21 esters was analysed in comparison with fluocinonide during a 24-hour period of time. The solvolysis was performed in an ethanol-water (90:10 v/v) mixture using the excess of NaHCO(3). The solvolytic mixtures of each investigated ester have been assayed by a RP-HPLC method using isocratic elution with methanol-water (75:25 v/v); flow rate 1 mL/min; detection at 238 nm; temperature 25 degrees C. Solvolytic rate constants were calculated from the obtained data. Geometry optimizations and charges calculations were carried out by Gaussian W03 software. A good correlation (R = 0.9924) was obtained between solvolytic rate constants and the polarity of the C-O2 bond of those esters. The established relation between solvolytic rate constant (K) and lipophilicity (cLogP) with experimental anti-inflammatory activity could be indicative for topical corticosteroid prodrug activation.en
dc.publisherMDPI, Basel
dc.relationinfo:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/172041/RS//
dc.rightsopenAccess
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.sourceMolecules
dc.subjectprodrugen
dc.subjectfluocinolone acetonide estersen
dc.subjectsolvolysisen
dc.subjectdescriptoren
dc.subjectin vitro modelen
dc.titleInvestigation of Solvolysis Kinetics of New Synthesized Fluocinolone Acetonide C-21 Esters-An In Vitro Model for Prodrug Activationen
dc.typearticle
dc.rights.licenseBY
dcterms.abstractЧудина, Оливера; Добричић, Владимир; Владимиров, Соте; Марковић, Бојан; Карљиковић-Рајић, Катарина; Савић, Владимир;
dc.citation.volume16
dc.citation.issue3
dc.citation.spage2658
dc.citation.epage2671
dc.citation.other16(3): 2658-2671
dc.citation.rankM22
dc.identifier.wos000288853400053
dc.identifier.doi10.3390/molecules16032658
dc.identifier.pmid21441868
dc.identifier.scopus2-s2.0-79953090073
dc.identifier.fulltexthttps://farfar.pharmacy.bg.ac.rs//bitstream/id/383/1522.pdf
dc.type.versionpublishedVersion


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Приказ основних података о документу