A base promoted cyclization of the protected N-propargylaminopyridines was shown to be an efficient method for the preparation of imidazo[1,2-a] pyridine derivatives. The reactions were carried out with a small excess of base, at room temperature or slightly above producing the heterocyclic products in moderate to good yields. The stereoelectronic properties of substituents on the pyridine ring were shown to influence the cyclization process.
TY - JOUR
AU - Husinec, Suren
AU - Marković, Rade
AU - Petković, Miloš
AU - Nasufović, Veselin
AU - Savić, Vladimir
PY - 2011
UR - http://farfar.pharmacy.bg.ac.rs/handle/123456789/1527
AB - A base promoted cyclization of the protected N-propargylaminopyridines was shown to be an efficient method for the preparation of imidazo[1,2-a] pyridine derivatives. The reactions were carried out with a small excess of base, at room temperature or slightly above producing the heterocyclic products in moderate to good yields. The stereoelectronic properties of substituents on the pyridine ring were shown to influence the cyclization process.
PB - Amer Chemical Soc, Washington
T2 - Organic Letters
T1 - A Base Promoted Cyclization of N-Propargylaminopyridines. Synthesis of Imidazo[1,2-a]pyridine Derivatives
VL - 13
IS - 9
SP - 2286
EP - 2289
DO - 10.1021/ol200508x
ER -
@article{
author = "Husinec, Suren and Marković, Rade and Petković, Miloš and Nasufović, Veselin and Savić, Vladimir",
year = "2011",
url = "http://farfar.pharmacy.bg.ac.rs/handle/123456789/1527",
abstract = "A base promoted cyclization of the protected N-propargylaminopyridines was shown to be an efficient method for the preparation of imidazo[1,2-a] pyridine derivatives. The reactions were carried out with a small excess of base, at room temperature or slightly above producing the heterocyclic products in moderate to good yields. The stereoelectronic properties of substituents on the pyridine ring were shown to influence the cyclization process.",
publisher = "Amer Chemical Soc, Washington",
journal = "Organic Letters",
title = "A Base Promoted Cyclization of N-Propargylaminopyridines. Synthesis of Imidazo[1,2-a]pyridine Derivatives",
volume = "13",
number = "9",
pages = "2286-2289",
doi = "10.1021/ol200508x"
}
Husinec, S., Marković, R., Petković, M., Nasufović, V.,& Savić, V. (2011). A Base Promoted Cyclization of N-Propargylaminopyridines. Synthesis of Imidazo[1,2-a]pyridine Derivatives.
Organic Letters
Amer Chemical Soc, Washington., 13(9), 2286-2289.
https://doi.org/10.1021/ol200508x
Husinec S, Marković R, Petković M, Nasufović V, Savić V. A Base Promoted Cyclization of N-Propargylaminopyridines. Synthesis of Imidazo[1,2-a]pyridine Derivatives. Organic Letters. 2011;13(9):2286-2289
Husinec Suren, Marković Rade, Petković Miloš, Nasufović Veselin, Savić Vladimir, "A Base Promoted Cyclization of N-Propargylaminopyridines. Synthesis of Imidazo[1,2-a]pyridine Derivatives" Organic Letters, 13, no. 9 (2011):2286-2289,
https://doi.org/10.1021/ol200508x .
