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An alkyl polyglucoside-mixed emulsifier as stabilizer of emulsion systems: The influence of colloidal structure on emulsions skin hydration potential

Authorized Users Only
2011
Authors
Savić, Snežana
Lukić, Milica
Pantelić, Ivana
Reichl, Stephan
Tamburić, Slobodanka
Mueller-Goymann, Christel
Article (Published version)
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Abstract
To be considered as a suitable vehicle for drugs/cosmetic actives, an emulsion system should have a number of desirable properties mainly dependent on surfactant used for its stabilization. In the current study, C12-14 alkyl polyglucoside (APG)-mixed emulsifier of natural origin has been investigated in a series of binary (emulsifier concentration 10-25% (w/w)) and ternary systems with fixed emulsifier content (15% (w/w)) with or without glycerol. To elucidate the systems' colloidal structure the following physicochemical techniques were employed: polarization and transmission electron microscopy, X-ray diffraction (WAXD and SAXD), thermal analysis (DSC and TGA), complex rheological, pH, and conductivity measurements. Additionally, the emulsion vehicles' skin hydration potential was tested in vivo, on human skin under occlusion. In a series of binary systems with fixed emulsifier/water ratios ranging from 10/90 to 25/75 the predominance of a lamellar mesophase was found, changing its c...haracter from a liquid crystalline to a gel crystalline type. The same was observed in gel emulsions containing equal amounts of emulsifier and oil (15% (w/w)), but varying in glycerol content (0-25%). Different emulsion samples exhibited different water distribution modes in the structure, reflecting their rheological behavior and also their skin hydration capacity.

Keywords:
Alkyl polyglucoside-mixed emulsifier / Lamellar mesophase / Water distribution / Rheological behavior / Skin hydration
Source:
Journal of Colloid and Interface Science, 2011, 358, 1, 182-191
Publisher:
  • Academic Press Inc Elsevier Science, San Diego
Funding / projects:
  • Development of micro- and nanosystems as carriers for drugs with anti-inflammatory effect and methods for their characterization (RS-34031)

DOI: 10.1016/j.jcis.2011.02.049

ISSN: 0021-9797

PubMed: 21421214

WoS: 000289600300025

Scopus: 2-s2.0-79953300461
[ Google Scholar ]
55
50
URI
https://farfar.pharmacy.bg.ac.rs/handle/123456789/1533
Collections
  • Radovi istraživača / Researchers’ publications
Institution/Community
Pharmacy
TY  - JOUR
AU  - Savić, Snežana
AU  - Lukić, Milica
AU  - Pantelić, Ivana
AU  - Reichl, Stephan
AU  - Tamburić, Slobodanka
AU  - Mueller-Goymann, Christel
PY  - 2011
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/1533
AB  - To be considered as a suitable vehicle for drugs/cosmetic actives, an emulsion system should have a number of desirable properties mainly dependent on surfactant used for its stabilization. In the current study, C12-14 alkyl polyglucoside (APG)-mixed emulsifier of natural origin has been investigated in a series of binary (emulsifier concentration 10-25% (w/w)) and ternary systems with fixed emulsifier content (15% (w/w)) with or without glycerol. To elucidate the systems' colloidal structure the following physicochemical techniques were employed: polarization and transmission electron microscopy, X-ray diffraction (WAXD and SAXD), thermal analysis (DSC and TGA), complex rheological, pH, and conductivity measurements. Additionally, the emulsion vehicles' skin hydration potential was tested in vivo, on human skin under occlusion. In a series of binary systems with fixed emulsifier/water ratios ranging from 10/90 to 25/75 the predominance of a lamellar mesophase was found, changing its character from a liquid crystalline to a gel crystalline type. The same was observed in gel emulsions containing equal amounts of emulsifier and oil (15% (w/w)), but varying in glycerol content (0-25%). Different emulsion samples exhibited different water distribution modes in the structure, reflecting their rheological behavior and also their skin hydration capacity.
PB  - Academic Press Inc Elsevier Science, San Diego
T2  - Journal of Colloid and Interface Science
T1  - An alkyl polyglucoside-mixed emulsifier as stabilizer of emulsion systems: The influence of colloidal structure on emulsions skin hydration potential
VL  - 358
IS  - 1
SP  - 182
EP  - 191
DO  - 10.1016/j.jcis.2011.02.049
ER  - 
@article{
author = "Savić, Snežana and Lukić, Milica and Pantelić, Ivana and Reichl, Stephan and Tamburić, Slobodanka and Mueller-Goymann, Christel",
year = "2011",
abstract = "To be considered as a suitable vehicle for drugs/cosmetic actives, an emulsion system should have a number of desirable properties mainly dependent on surfactant used for its stabilization. In the current study, C12-14 alkyl polyglucoside (APG)-mixed emulsifier of natural origin has been investigated in a series of binary (emulsifier concentration 10-25% (w/w)) and ternary systems with fixed emulsifier content (15% (w/w)) with or without glycerol. To elucidate the systems' colloidal structure the following physicochemical techniques were employed: polarization and transmission electron microscopy, X-ray diffraction (WAXD and SAXD), thermal analysis (DSC and TGA), complex rheological, pH, and conductivity measurements. Additionally, the emulsion vehicles' skin hydration potential was tested in vivo, on human skin under occlusion. In a series of binary systems with fixed emulsifier/water ratios ranging from 10/90 to 25/75 the predominance of a lamellar mesophase was found, changing its character from a liquid crystalline to a gel crystalline type. The same was observed in gel emulsions containing equal amounts of emulsifier and oil (15% (w/w)), but varying in glycerol content (0-25%). Different emulsion samples exhibited different water distribution modes in the structure, reflecting their rheological behavior and also their skin hydration capacity.",
publisher = "Academic Press Inc Elsevier Science, San Diego",
journal = "Journal of Colloid and Interface Science",
title = "An alkyl polyglucoside-mixed emulsifier as stabilizer of emulsion systems: The influence of colloidal structure on emulsions skin hydration potential",
volume = "358",
number = "1",
pages = "182-191",
doi = "10.1016/j.jcis.2011.02.049"
}
Savić, S., Lukić, M., Pantelić, I., Reichl, S., Tamburić, S.,& Mueller-Goymann, C.. (2011). An alkyl polyglucoside-mixed emulsifier as stabilizer of emulsion systems: The influence of colloidal structure on emulsions skin hydration potential. in Journal of Colloid and Interface Science
Academic Press Inc Elsevier Science, San Diego., 358(1), 182-191.
https://doi.org/10.1016/j.jcis.2011.02.049
Savić S, Lukić M, Pantelić I, Reichl S, Tamburić S, Mueller-Goymann C. An alkyl polyglucoside-mixed emulsifier as stabilizer of emulsion systems: The influence of colloidal structure on emulsions skin hydration potential. in Journal of Colloid and Interface Science. 2011;358(1):182-191.
doi:10.1016/j.jcis.2011.02.049 .
Savić, Snežana, Lukić, Milica, Pantelić, Ivana, Reichl, Stephan, Tamburić, Slobodanka, Mueller-Goymann, Christel, "An alkyl polyglucoside-mixed emulsifier as stabilizer of emulsion systems: The influence of colloidal structure on emulsions skin hydration potential" in Journal of Colloid and Interface Science, 358, no. 1 (2011):182-191,
https://doi.org/10.1016/j.jcis.2011.02.049 . .

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