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dc.creatorVučinić, Violeta
dc.creatorSkodrić-Trifunović, Vesna
dc.creatorIgnjatović, Svetlana
dc.date.accessioned2019-09-02T11:24:51Z
dc.date.available2019-09-02T11:24:51Z
dc.date.issued2011
dc.identifier.issn1070-5287
dc.identifier.urihttps://farfar.pharmacy.bg.ac.rs/handle/123456789/1534
dc.description.abstractPurpose of review Calcium metabolism impairments have long been recognized as a complication of sarcoidosis. For more than six decades physicians and investigators have been trying to elucidate this severe problem; nevertheless it seems puzzlingly new for both readers and researchers. Recent findings This review highlights the problems of calcium metabolism in sarcoidosis in relation to vitamin D synthesis, which is definitely altered by granulomatous inflammation. Increasing evidence suggests that vitamin D is an immunomodulating hormone that inhibits both antigen presentation by cells of the innate immune system, and the cytokine release and proliferation of Th1 cells. As calcium homeostasis is primary controlled by levels of vitamin D, parathyroid hormone (PTH) and calcitonin, this literature review emphasizes the role of general immunomodulating properties of vitamin D and the correlation with calcium metabolism impairments, with the special accent on already known interactions with sarcoidosis. Summary Granuloma formation has been related to a failure of the innate immune system. One of the possible explanations is a vitamin D deficiency. The evidence-based findings on calcium metabolism impairments and the interactions with vitamin D might help both clinicians and researchers in developing new strategies.en
dc.publisherLippincott Williams & Wilkins, Philadelphia
dc.relationinfo:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/175046/RS//
dc.rightsrestrictedAccess
dc.sourceCurrent Opinion in Pulmonary Medicine
dc.subjectcalcium metabolismen
dc.subjectsarcoidosisen
dc.subjectvitamin Den
dc.titleHow to diagnose and manage difficult problems of calcium metabolism in sarcoidosis: an evidence-based reviewen
dc.typearticle
dc.rights.licenseARR
dcterms.abstractВучинић, Виолета; Скодрић-Трифуновић, Весна; Игњатовић, Светлана;
dc.citation.volume17
dc.citation.issue5
dc.citation.spage297
dc.citation.epage302
dc.citation.other17(5): 297-302
dc.citation.rankM22
dc.identifier.wos000293774800001
dc.identifier.doi10.1097/MCP.0b013e328348b3cb
dc.identifier.pmid21832916
dc.identifier.scopus2-s2.0-80051748101
dc.type.versionpublishedVersion


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