The methanol extract of ripe Rumex crispus L. fruits was evaluated for its antioxidant potential by assays for ferric-reducing antioxidant power (FRAP), DPPH-free radical scavenging activity (DPPH) and the influence on lipid peroxidation in liposomes (LP). Considerable activity was observed in all test systems (FRAP: 9.9 mmol Fe2+/g; DPPH IC50: 3.7 mu g/mL; LP IC50: 4.9 mu g/mL), comparable to that of BHT (FRAP: 8.0 mu g/mL; DPPH IC50: 19.4 mu g/mL; LP IC50: 3.5 mu g/mL), but lower than the activity of ascorbic acid, rutin and quercetin, used as positive control substances. The in vivo effects were evaluated in several hepatic antioxidant systems (activities of LPx, GSH-Px, Px, CAT and XOD, as well as GSH content), after treatment with the studied yellow dock extract in different doses, or in combination with carbon tetrachloride (CCl4). Pretreatment with the R. crispus extract inhibited CCl4-induced oxidative stress by decreasing LPx and increasing GSH content in a dose dependent mann...er, bringing the levels of antioxidant enzymes to near control values. Copyright
Keywords:
Rumex crispus L. / antioxidant activity / ferric-reducing antioxidant power / DPPH free radical scavenging activity / lipid peroxidation
TY - JOUR
AU - Maksimović, Zoran
AU - Kovačević, Nada
AU - Lakušić, Branislava
AU - Cebović, Tatjana
PY - 2011
UR - http://farfar.pharmacy.bg.ac.rs/handle/123456789/1535
AB - The methanol extract of ripe Rumex crispus L. fruits was evaluated for its antioxidant potential by assays for ferric-reducing antioxidant power (FRAP), DPPH-free radical scavenging activity (DPPH) and the influence on lipid peroxidation in liposomes (LP). Considerable activity was observed in all test systems (FRAP: 9.9 mmol Fe2+/g; DPPH IC50: 3.7 mu g/mL; LP IC50: 4.9 mu g/mL), comparable to that of BHT (FRAP: 8.0 mu g/mL; DPPH IC50: 19.4 mu g/mL; LP IC50: 3.5 mu g/mL), but lower than the activity of ascorbic acid, rutin and quercetin, used as positive control substances. The in vivo effects were evaluated in several hepatic antioxidant systems (activities of LPx, GSH-Px, Px, CAT and XOD, as well as GSH content), after treatment with the studied yellow dock extract in different doses, or in combination with carbon tetrachloride (CCl4). Pretreatment with the R. crispus extract inhibited CCl4-induced oxidative stress by decreasing LPx and increasing GSH content in a dose dependent manner, bringing the levels of antioxidant enzymes to near control values. Copyright
PB - Wiley, Hoboken
T2 - Phytotherapy Research
T1 - Antioxidant Activity of Yellow Dock (Rumex crispus L., Polygonaceae) Fruit Extract
VL - 25
IS - 1
SP - 101
EP - 105
DO - 10.1002/ptr.3234
ER -
@article{
author = "Maksimović, Zoran and Kovačević, Nada and Lakušić, Branislava and Cebović, Tatjana",
year = "2011",
url = "http://farfar.pharmacy.bg.ac.rs/handle/123456789/1535",
abstract = "The methanol extract of ripe Rumex crispus L. fruits was evaluated for its antioxidant potential by assays for ferric-reducing antioxidant power (FRAP), DPPH-free radical scavenging activity (DPPH) and the influence on lipid peroxidation in liposomes (LP). Considerable activity was observed in all test systems (FRAP: 9.9 mmol Fe2+/g; DPPH IC50: 3.7 mu g/mL; LP IC50: 4.9 mu g/mL), comparable to that of BHT (FRAP: 8.0 mu g/mL; DPPH IC50: 19.4 mu g/mL; LP IC50: 3.5 mu g/mL), but lower than the activity of ascorbic acid, rutin and quercetin, used as positive control substances. The in vivo effects were evaluated in several hepatic antioxidant systems (activities of LPx, GSH-Px, Px, CAT and XOD, as well as GSH content), after treatment with the studied yellow dock extract in different doses, or in combination with carbon tetrachloride (CCl4). Pretreatment with the R. crispus extract inhibited CCl4-induced oxidative stress by decreasing LPx and increasing GSH content in a dose dependent manner, bringing the levels of antioxidant enzymes to near control values. Copyright",
publisher = "Wiley, Hoboken",
journal = "Phytotherapy Research",
title = "Antioxidant Activity of Yellow Dock (Rumex crispus L., Polygonaceae) Fruit Extract",
volume = "25",
number = "1",
pages = "101-105",
doi = "10.1002/ptr.3234"
}
Maksimović, Z., Kovačević, N., Lakušić, B.,& Cebović, T. (2011). Antioxidant Activity of Yellow Dock (Rumex crispus L., Polygonaceae) Fruit Extract.
Phytotherapy Research
Wiley, Hoboken., 25(1), 101-105.
https://doi.org/10.1002/ptr.3234
Maksimović Z, Kovačević N, Lakušić B, Cebović T. Antioxidant Activity of Yellow Dock (Rumex crispus L., Polygonaceae) Fruit Extract. Phytotherapy Research. 2011;25(1):101-105
Maksimović Zoran, Kovačević Nada, Lakušić Branislava, Cebović Tatjana, "Antioxidant Activity of Yellow Dock (Rumex crispus L., Polygonaceae) Fruit Extract" Phytotherapy Research, 25, no. 1 (2011):101-105,
https://doi.org/10.1002/ptr.3234 .
