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dc.creatorMaksimović, Zoran
dc.creatorKovačević, Nada
dc.creatorLakušić, Branislava
dc.creatorCebović, Tatjana
dc.date.accessioned2019-09-02T11:24:52Z
dc.date.available2019-09-02T11:24:52Z
dc.date.issued2011
dc.identifier.issn0951-418X
dc.identifier.urihttp://farfar.pharmacy.bg.ac.rs/handle/123456789/1535
dc.description.abstractThe methanol extract of ripe Rumex crispus L. fruits was evaluated for its antioxidant potential by assays for ferric-reducing antioxidant power (FRAP), DPPH-free radical scavenging activity (DPPH) and the influence on lipid peroxidation in liposomes (LP). Considerable activity was observed in all test systems (FRAP: 9.9 mmol Fe2+/g; DPPH IC50: 3.7 mu g/mL; LP IC50: 4.9 mu g/mL), comparable to that of BHT (FRAP: 8.0 mu g/mL; DPPH IC50: 19.4 mu g/mL; LP IC50: 3.5 mu g/mL), but lower than the activity of ascorbic acid, rutin and quercetin, used as positive control substances. The in vivo effects were evaluated in several hepatic antioxidant systems (activities of LPx, GSH-Px, Px, CAT and XOD, as well as GSH content), after treatment with the studied yellow dock extract in different doses, or in combination with carbon tetrachloride (CCl4). Pretreatment with the R. crispus extract inhibited CCl4-induced oxidative stress by decreasing LPx and increasing GSH content in a dose dependent manner, bringing the levels of antioxidant enzymes to near control values. Copyrighten
dc.publisherWiley, Hoboken
dc.relationinfo:eu-repo/grantAgreement/MESTD/MPN2006-2010/143012/RS//
dc.rightsrestrictedAccess
dc.sourcePhytotherapy Research
dc.subjectRumex crispus L.en
dc.subjectantioxidant activityen
dc.subjectferric-reducing antioxidant poweren
dc.subjectDPPH free radical scavenging activityen
dc.subjectlipid peroxidationen
dc.titleAntioxidant Activity of Yellow Dock (Rumex crispus L., Polygonaceae) Fruit Extracten
dc.typearticle
dc.rights.licenseARR
dcterms.abstractЦебовић, Татјана; Ковачевић, Нада; Лакушић, Бранислава; Максимовић, Зоран;
dc.citation.volume25
dc.citation.issue1
dc.citation.spage101
dc.citation.epage105
dc.citation.other25(1): 101-105
dc.citation.rankM22
dc.identifier.wos000285848700016
dc.identifier.doi10.1002/ptr.3234
dc.identifier.pmid20623623
dc.identifier.scopus2-s2.0-78650635774
dc.identifier.rcubconv_2382
dc.type.versionpublishedVersion


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