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Spectrophotometric study of diclofenac-Fe(III) complex

Authorized Users Only
1997
Authors
Agatonović-Kuštrin, Snežana
Živanović, L
Zečević, Mira
Radulović, D
Article (Published version)
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Abstract
A multifactor optimisation technique is successfully applied to develop a new spectrophotometric method in which diclofenac sodium is analysed and determined as it's Fe(III) complex. The effect of simultaneously varying the pH, ionic strength and concentration of colour reagents in the reaction mixture were studied. A four-variable two-level factorial design was used to investigate the significance of each variable and interactions between them. A response surface design was used to optimise complex formation and extraction. It was established that diclofenac reacts with Fe(III) chloride, in the presence of ammonium thiocyanate, in the pH range 4.2-6.5, forming a red chloroform extractable (2:1) complex with maximum absorbance at 481 nm. By applying the methods of Sommer and Job involving non-equimolar solutions the conditional stability constant of the complex, at the optimum pH of 6.0 and an ionic strength mu = 0.19M, was found to be 10(6.4). Good agreement with Beer's law was found ...for diclofenac concentrations up to mmol l(-1). The nominal percent recovery of diclofenac was 98.8% (n = 10). The lower limit of sensitivity of the method was found to be 14.7 mu g ml(-1).

Source:
Journal of Pharmaceutical and Biomedical Analysis, 1997, 16, 1, 147-153
Publisher:
  • Pergamon-Elsevier Science Ltd, Oxford

DOI: 10.1016/S0731-7085(97)00016-2

ISSN: 0731-7085

PubMed: 9447562

WoS: A1997YF13700018

Scopus: 2-s2.0-0031239353
[ Google Scholar ]
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34
URI
https://farfar.pharmacy.bg.ac.rs/handle/123456789/154
Collections
  • Radovi istraživača / Researchers’ publications
Institution/Community
Pharmacy
TY  - JOUR
AU  - Agatonović-Kuštrin, Snežana
AU  - Živanović, L
AU  - Zečević, Mira
AU  - Radulović, D
PY  - 1997
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/154
AB  - A multifactor optimisation technique is successfully applied to develop a new spectrophotometric method in which diclofenac sodium is analysed and determined as it's Fe(III) complex. The effect of simultaneously varying the pH, ionic strength and concentration of colour reagents in the reaction mixture were studied. A four-variable two-level factorial design was used to investigate the significance of each variable and interactions between them. A response surface design was used to optimise complex formation and extraction. It was established that diclofenac reacts with Fe(III) chloride, in the presence of ammonium thiocyanate, in the pH range 4.2-6.5, forming a red chloroform extractable (2:1) complex with maximum absorbance at 481 nm. By applying the methods of Sommer and Job involving non-equimolar solutions the conditional stability constant of the complex, at the optimum pH of 6.0 and an ionic strength mu = 0.19M, was found to be 10(6.4). Good agreement with Beer's law was found for diclofenac concentrations up to mmol l(-1). The nominal percent recovery of diclofenac was 98.8% (n = 10). The lower limit of sensitivity of the method was found to be 14.7 mu g ml(-1).
PB  - Pergamon-Elsevier Science Ltd, Oxford
T2  - Journal of Pharmaceutical and Biomedical Analysis
T1  - Spectrophotometric study of diclofenac-Fe(III) complex
VL  - 16
IS  - 1
SP  - 147
EP  - 153
DO  - 10.1016/S0731-7085(97)00016-2
ER  - 
@article{
author = "Agatonović-Kuštrin, Snežana and Živanović, L and Zečević, Mira and Radulović, D",
year = "1997",
abstract = "A multifactor optimisation technique is successfully applied to develop a new spectrophotometric method in which diclofenac sodium is analysed and determined as it's Fe(III) complex. The effect of simultaneously varying the pH, ionic strength and concentration of colour reagents in the reaction mixture were studied. A four-variable two-level factorial design was used to investigate the significance of each variable and interactions between them. A response surface design was used to optimise complex formation and extraction. It was established that diclofenac reacts with Fe(III) chloride, in the presence of ammonium thiocyanate, in the pH range 4.2-6.5, forming a red chloroform extractable (2:1) complex with maximum absorbance at 481 nm. By applying the methods of Sommer and Job involving non-equimolar solutions the conditional stability constant of the complex, at the optimum pH of 6.0 and an ionic strength mu = 0.19M, was found to be 10(6.4). Good agreement with Beer's law was found for diclofenac concentrations up to mmol l(-1). The nominal percent recovery of diclofenac was 98.8% (n = 10). The lower limit of sensitivity of the method was found to be 14.7 mu g ml(-1).",
publisher = "Pergamon-Elsevier Science Ltd, Oxford",
journal = "Journal of Pharmaceutical and Biomedical Analysis",
title = "Spectrophotometric study of diclofenac-Fe(III) complex",
volume = "16",
number = "1",
pages = "147-153",
doi = "10.1016/S0731-7085(97)00016-2"
}
Agatonović-Kuštrin, S., Živanović, L., Zečević, M.,& Radulović, D.. (1997). Spectrophotometric study of diclofenac-Fe(III) complex. in Journal of Pharmaceutical and Biomedical Analysis
Pergamon-Elsevier Science Ltd, Oxford., 16(1), 147-153.
https://doi.org/10.1016/S0731-7085(97)00016-2
Agatonović-Kuštrin S, Živanović L, Zečević M, Radulović D. Spectrophotometric study of diclofenac-Fe(III) complex. in Journal of Pharmaceutical and Biomedical Analysis. 1997;16(1):147-153.
doi:10.1016/S0731-7085(97)00016-2 .
Agatonović-Kuštrin, Snežana, Živanović, L, Zečević, Mira, Radulović, D, "Spectrophotometric study of diclofenac-Fe(III) complex" in Journal of Pharmaceutical and Biomedical Analysis, 16, no. 1 (1997):147-153,
https://doi.org/10.1016/S0731-7085(97)00016-2 . .

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