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dc.creatorKrajišnik, Danina
dc.creatorDaković, Aleksandra
dc.creatorMilojević, Maja
dc.creatorMalenović, Anđelija
dc.creatorKragović, Milan
dc.creatorBajuk-Bogdanović, Danica
dc.creatorDondur, Vera
dc.creatorMilić, Jela
dc.date.accessioned2019-09-02T11:25:00Z
dc.date.available2019-09-02T11:25:00Z
dc.date.issued2011
dc.identifier.issn0927-7765
dc.identifier.urihttp://farfar.pharmacy.bg.ac.rs/handle/123456789/1541
dc.description.abstractIn this study an investigation of a model drug sorption onto cationic surfactant-modified natural zeolites as a drug formulation excipient was performed. Natural zeolite was modified with cetylpyridinium chloride in amounts equivalent to 100, 200 and 300% of its external cation-exchange capacity. The starting material and obtained organozeolites were characterized by Fourier transform infrared spectroscopy, zeta potential measurements and thermal analysis. In vitro sorption of diclofenac sodium as a model drug was studied for all surfactant/zeolite composites by means of sorption isotherm measurements in aqueous solutions (pH 7.4). The modified zeolites with three levels of surfactant coverage within the short activation time were prepared. Zeta potential measurements and thermal analysis showed that when the surfactant loading level was equal to external cation-exchange value, almost monolayer of organic phase were present at the zeolitic surface while higher amounts of surfactant produced less extended bilayers, ordered bilayers or admicelles at the zeolitic surface. Modified zeolites, obtained in this manner, were effective in diclofenac sodium sorption and the organic phase derived from adsorbed cetylpyridinium chloride was the primary sorption phase for the model drug. The Langmuir isotherm was found to describe the equilibrium sorption data well over the entire concentration range. The separate contributions of the adsorption and partition to the total sorption of DS were analyzed mathematically. Results revealed that that adsorption and partitioning of the model drug take place simultaneously.en
dc.publisherElsevier Science BV, Amsterdam
dc.relationMinistry of Science and Technological Development, Republic of Serbia
dc.rightsrestrictedAccess
dc.sourceColloids and Surfaces B: Biointerfaces
dc.subjectClinoptiloliteen
dc.subjectExcipienten
dc.subjectCationic surfactanten
dc.subjectDrug sorptionen
dc.subjectPartitioningen
dc.titleProperties of diclofenac sodium sorption onto natural zeolite modified with cetylpyridinium chlorideen
dc.typearticle
dc.rights.licenseARR
dcterms.abstractБајук-Богдановић, Даница; Крајишник, Данина; Маленовић, Aнђелија; Дондур, Вера; Даковић, Aлександра; Милић, Јела; Краговић, Милан; Милојевић, Маја;
dc.citation.volume83
dc.citation.issue1
dc.citation.spage165
dc.citation.epage172
dc.citation.other83(1): 165-172
dc.citation.rankM21
dc.identifier.wos000286860900025
dc.identifier.doi10.1016/j.colsurfb.2010.11.024
dc.identifier.pmid21134730
dc.identifier.scopus2-s2.0-78650194655
dc.identifier.rcubconv_2390
dc.type.versionpublishedVersion


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