Antimicrobial Activity of the Essential Oil of Greek Endemic Stachys spruneri and its Main Component, Isoabienol
Apstrakt
The essential oils of Stachys spruneri Boiss. (sample A and sample B) were analyzed by GC and GC-MS. (+)-Isoabienol was the dominant component (49.5 and 48.2%, respectively of the total oils) among seventy-two identified constituents. Isoabienol was separated, purified by preparative thin-slayer chromatography, and further identified by means of physicochemical and spectrometric analysis. The microbial growth inhibitory properties of the essential oil and its main metabolite, the labdane diterpene isoabienol, were determined using the broth microdilution method against eight laboratory strains of bacteria (Gram- positive: Staphylococcus aureus, S. epidermidis, Micrococcus luteus, Enterococcus faecalis, Bacillus subtilis, and Gram- negative: Escherichia coli, Klebsiella pneumoniae, Pseudomonas aeruginosa, and two strains of the yeast Candida albicans. Both essential oil and isoabienol showed considerable activity against all the microorganisms tested, with the isolated compound being mo...st active.
Ključne reči:
Stachys spruneri / essential oil / isoabienol / antimicrobial activityIzvor:
Natural Product Communications, 2011, 6, 2, 277-280Izdavač:
- Natural Products Inc, Westerville
Institucija/grupa
PharmacyTY - JOUR AU - Koutsaviti, Aikaterini AU - Milenković, Marina AU - Tzakou, Olga PY - 2011 UR - https://farfar.pharmacy.bg.ac.rs/handle/123456789/1546 AB - The essential oils of Stachys spruneri Boiss. (sample A and sample B) were analyzed by GC and GC-MS. (+)-Isoabienol was the dominant component (49.5 and 48.2%, respectively of the total oils) among seventy-two identified constituents. Isoabienol was separated, purified by preparative thin-slayer chromatography, and further identified by means of physicochemical and spectrometric analysis. The microbial growth inhibitory properties of the essential oil and its main metabolite, the labdane diterpene isoabienol, were determined using the broth microdilution method against eight laboratory strains of bacteria (Gram- positive: Staphylococcus aureus, S. epidermidis, Micrococcus luteus, Enterococcus faecalis, Bacillus subtilis, and Gram- negative: Escherichia coli, Klebsiella pneumoniae, Pseudomonas aeruginosa, and two strains of the yeast Candida albicans. Both essential oil and isoabienol showed considerable activity against all the microorganisms tested, with the isolated compound being most active. PB - Natural Products Inc, Westerville T2 - Natural Product Communications T1 - Antimicrobial Activity of the Essential Oil of Greek Endemic Stachys spruneri and its Main Component, Isoabienol VL - 6 IS - 2 SP - 277 EP - 280 UR - https://hdl.handle.net/21.15107/rcub_farfar_1546 ER -
@article{ author = "Koutsaviti, Aikaterini and Milenković, Marina and Tzakou, Olga", year = "2011", abstract = "The essential oils of Stachys spruneri Boiss. (sample A and sample B) were analyzed by GC and GC-MS. (+)-Isoabienol was the dominant component (49.5 and 48.2%, respectively of the total oils) among seventy-two identified constituents. Isoabienol was separated, purified by preparative thin-slayer chromatography, and further identified by means of physicochemical and spectrometric analysis. The microbial growth inhibitory properties of the essential oil and its main metabolite, the labdane diterpene isoabienol, were determined using the broth microdilution method against eight laboratory strains of bacteria (Gram- positive: Staphylococcus aureus, S. epidermidis, Micrococcus luteus, Enterococcus faecalis, Bacillus subtilis, and Gram- negative: Escherichia coli, Klebsiella pneumoniae, Pseudomonas aeruginosa, and two strains of the yeast Candida albicans. Both essential oil and isoabienol showed considerable activity against all the microorganisms tested, with the isolated compound being most active.", publisher = "Natural Products Inc, Westerville", journal = "Natural Product Communications", title = "Antimicrobial Activity of the Essential Oil of Greek Endemic Stachys spruneri and its Main Component, Isoabienol", volume = "6", number = "2", pages = "277-280", url = "https://hdl.handle.net/21.15107/rcub_farfar_1546" }
Koutsaviti, A., Milenković, M.,& Tzakou, O.. (2011). Antimicrobial Activity of the Essential Oil of Greek Endemic Stachys spruneri and its Main Component, Isoabienol. in Natural Product Communications Natural Products Inc, Westerville., 6(2), 277-280. https://hdl.handle.net/21.15107/rcub_farfar_1546
Koutsaviti A, Milenković M, Tzakou O. Antimicrobial Activity of the Essential Oil of Greek Endemic Stachys spruneri and its Main Component, Isoabienol. in Natural Product Communications. 2011;6(2):277-280. https://hdl.handle.net/21.15107/rcub_farfar_1546 .
Koutsaviti, Aikaterini, Milenković, Marina, Tzakou, Olga, "Antimicrobial Activity of the Essential Oil of Greek Endemic Stachys spruneri and its Main Component, Isoabienol" in Natural Product Communications, 6, no. 2 (2011):277-280, https://hdl.handle.net/21.15107/rcub_farfar_1546 .