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dc.creatorZeljković, Aleksandra
dc.creatorVekić, Jelena
dc.creatorSpasojević-Kalimanovska, Vesna
dc.creatorJelić-Ivanović, Zorana
dc.creatorPeco-Antić, Amira
dc.creatorKostić, Mirjana
dc.creatorVasić, Dragan
dc.creatorSpasić, Slavica
dc.date.accessioned2019-09-02T11:25:12Z
dc.date.available2019-09-02T11:25:12Z
dc.date.issued2011
dc.identifier.issn0934-0874
dc.identifier.urihttp://farfar.pharmacy.bg.ac.rs/handle/123456789/1549
dc.description.abstractRenal transplant recipients often suffer from dyslipidemia which is one of the principal risk factors for cardiovascular disease. This study sought to determine characteristics of high-density lipoprotein (HDL) and low-density lipoprotein (LDL) particles and their associations with carotid intima-media thickness (cIMT) in a group of pediatric renal transplant recipients. We also examined the influence of immunosuppressive therapy on measured LDL and HDL particle characteristics. HDL size and subclass distribution were determined using gradient gel electrophoresis, while concentrations of small, dense LDL (sdLDL)-cholesterol (sdLDL-C) and sdLDL-apolipoprotein B (sdLDL-apoB) using heparin-magnesium precipitation method in 21 renal transplant recipients and 32 controls. Renal transplant recipients had less HDL 2b (P lt 0.001), but more HDL 3a (P lt 0.01) and 3b (P lt 0.001) subclasses. They also had increased sdLDL-C (P lt 0.01) and sdLDL-apoB (P lt 0.05) levels. The proportion of the HDL 3b subclasses was a significant predictor of increased cIMT (P lt 0.05). Patients treated with cyclosporine had significantly higher sdLDL-C and sdLDL-apoB concentrations (P lt 0.05) when compared with those on tacrolimus therapy. Pediatric renal transplant recipients have impaired distribution of HDL and LDL particles. Changes in the proportion of small-sized HDL particles are significantly associated with cIMT. Advanced lipid testing might be useful in evaluating the effects of immunosuppressive therapy.en
dc.publisherWiley-Blackwell, Malden
dc.relationinfo:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/175035/RS//
dc.rightsopenAccess
dc.sourceTransplantation
dc.subjectearly atherosclerosisen
dc.subjectcarotid intima-media thicknessen
dc.subjectimmunosuppressive therapyen
dc.subjectpediatric renal transplantationen
dc.subjectsmall dense low-density lipoproteinen
dc.subjectsmall-sized high-density lipoprotein subclassesen
dc.titleCharacteristics of low-density and high-density lipoprotein subclasses in pediatric renal transplant recipientsen
dc.typearticle
dc.rights.licenseARR
dcterms.abstractПецо-Aнтић, Aмира; Зељковић, Aлександра; Спасојевић-Калимановска, Весна; Васић, Драган; Јелић-Ивановић, Зорана; Спасић, Славица; Векић, Јелена; Костић, Мирјана;
dc.citation.volume24
dc.citation.issue11
dc.citation.spage1094
dc.citation.epage1102
dc.citation.other24(11): 1094-1102
dc.citation.rankM21
dc.identifier.wos000295835500012
dc.identifier.doi10.1111/j.1432-2277.2011.01313.x
dc.identifier.pmid21848901
dc.identifier.scopus2-s2.0-80053935006
dc.identifier.fulltexthttp://farfar.pharmacy.bg.ac.rs//bitstream/id/402/1547.pdf
dc.identifier.rcubconv_2543
dc.type.versionpublishedVersion


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