Приказ основних података о документу

dc.creatorAgatonović-Kuštrin, Snežana
dc.creatorŽivanović, L
dc.creatorZečević, Mira
dc.creatorRadulović, D
dc.date.accessioned2019-09-02T10:49:51Z
dc.date.available2019-09-02T10:49:51Z
dc.date.issued1997
dc.identifier.issn0731-7085
dc.identifier.urihttps://farfar.pharmacy.bg.ac.rs/handle/123456789/154
dc.description.abstractA multifactor optimisation technique is successfully applied to develop a new spectrophotometric method in which diclofenac sodium is analysed and determined as it's Fe(III) complex. The effect of simultaneously varying the pH, ionic strength and concentration of colour reagents in the reaction mixture were studied. A four-variable two-level factorial design was used to investigate the significance of each variable and interactions between them. A response surface design was used to optimise complex formation and extraction. It was established that diclofenac reacts with Fe(III) chloride, in the presence of ammonium thiocyanate, in the pH range 4.2-6.5, forming a red chloroform extractable (2:1) complex with maximum absorbance at 481 nm. By applying the methods of Sommer and Job involving non-equimolar solutions the conditional stability constant of the complex, at the optimum pH of 6.0 and an ionic strength mu = 0.19M, was found to be 10(6.4). Good agreement with Beer's law was found for diclofenac concentrations up to mmol l(-1). The nominal percent recovery of diclofenac was 98.8% (n = 10). The lower limit of sensitivity of the method was found to be 14.7 mu g ml(-1).en
dc.publisherPergamon-Elsevier Science Ltd, Oxford
dc.rightsrestrictedAccess
dc.sourceJournal of Pharmaceutical and Biomedical Analysis
dc.titleSpectrophotometric study of diclofenac-Fe(III) complexen
dc.typearticle
dc.rights.licenseARR
dcterms.abstractЗечевић, Мира; Радуловић, Д; Aгатоновић-Куштрин, Снежана; Живановић, Л;
dc.citation.volume16
dc.citation.issue1
dc.citation.spage147
dc.citation.epage153
dc.citation.other16(1): 147-153
dc.identifier.wosA1997YF13700018
dc.identifier.doi10.1016/S0731-7085(97)00016-2
dc.identifier.pmid9447562
dc.identifier.scopus2-s2.0-0031239353
dc.type.versionpublishedVersion


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Приказ основних података о документу