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dc.creatorBecarević, Mirjana
dc.creatorSeferović, Jelena
dc.creatorIgnjatović, Svetlana
dc.creatorSingh, Sandra
dc.creatorMajkić-Singh, Nada
dc.date.accessioned2019-09-02T11:25:14Z
dc.date.available2019-09-02T11:25:14Z
dc.date.issued2011
dc.identifier.issn1043-4666
dc.identifier.urihttp://farfar.pharmacy.bg.ac.rs/handle/123456789/1552
dc.description.abstractObjective: In vitro, stimulation of monocytes with antiphospholipid (aPL) antibodies resulted in increased secretion of TNF-alpha, but association of aPL with features of diabetes mellitus is not clarified yet. Therefore, we investigated the distribution of anticardiolipin (aCL), anti-beta 2gpI (a beta 2gpI), anti-annexin A5 (aannxA5), and anti-oxLDL (aoxLDL) antibodies, and TNF-alpha in well-formed group of 78 patients with type II diabetes mellitus without vascular complications. Methods: Investigated antibodies and TNF-alpha concentrations were measured by ELISA. Results: Antiphospholipid antibodies were in positive correlation with TNF-alpha concentrations: aCL IgG (r = 0.303, p = 0.007), aCL IgM (r = 0.386, p = 0.000), a beta 2gpI IgG (r = 0.499, p = 0.000), a beta 2gpI IgM (r = 0.462, p = 0.000), aanxA5 IgG (r = 0.479, p = 0.000), aanxA5 IgM (r = 0.641, p = 0.000), aoxLDL (IgG + IgM, r = 0.279, p = 0.000). Anticardiolipin-positive and aCL-negative subgroups differed in TNF-alpha concentrations (Mann-Whitney, p = 0.032). Significantly elevated LDL concentrations were noticed in aCL-positive patients with disease duration 10-15 years (chi(2) = 15.000, p = 0.000) and apoB concentrations were elevated in aoxLDL-positive patients with disease duration 7-10 years (chi(2) = 3.938, p = 0.047). Conclusion: Significant association of antiphospholipid antibodies and TNF-alpha might be a marker of severe atherogenic profile (suggested by increased levels of lipids in aPL-positive subgroups) and should be used for the stratification of patients with an increased risk for future deterioration of the disease.en
dc.publisherAcademic Press Ltd- Elsevier Science Ltd, London
dc.relationinfo:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/175036/RS//
dc.rightsrestrictedAccess
dc.sourceCytokine
dc.subjectAntiphospholipid antibodiesen
dc.subjectTNF-alphaen
dc.subjectDiabetes mellitus type IIen
dc.subjectAtherosclerosisen
dc.titleSignificant association of antiphospholipid antibodies and TNF-alpha: Marker of severe atherogenic profile of patients with type II diabetes mellitus without micro and/or macrovascular complicationsen
dc.typearticle
dc.rights.licenseARR
dcterms.abstractСеферовић, Јелена; Игњатовић, Светлана; Мајкић-Сингх, Нада; Бецаревић, Мирјана; Сингх, Сандра;
dc.citation.volume55
dc.citation.issue2
dc.citation.spage301
dc.citation.epage306
dc.citation.other55(2): 301-306
dc.citation.rankM22
dc.identifier.wos000293158100021
dc.identifier.doi10.1016/j.cyto.2011.05.001
dc.identifier.pmid21621418
dc.identifier.scopus2-s2.0-80955179024
dc.identifier.rcubconv_2483
dc.type.versionpublishedVersion


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