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dc.creatorŠumarac, Zorica
dc.creatorSuvajdzić, Nada
dc.creatorIgnjatović, Svetlana
dc.creatorMajkić-Singh, Nada
dc.creatorJanić, Dragana
dc.creatorPetakov, Milan
dc.creatorĐorđević, Maja
dc.creatorMitrović, Mirjana
dc.creatorDajak, Marijana
dc.creatorGolubović, Milka
dc.creatorRodić, Predrag
dc.date.accessioned2019-09-02T11:25:18Z
dc.date.available2019-09-02T11:25:18Z
dc.date.issued2011
dc.identifier.issn0009-9120
dc.identifier.urihttp://farfar.pharmacy.bg.ac.rs/handle/123456789/1553
dc.description.abstractObjectives: The aim of the study was to evaluate the efficiency of the biomarkers chitotriosidase (Chito), total acid phosphatase (TACP), angiotensin converting enzyme (ACE) and ferritin in the diagnosis of Gaucher disease (GD) and to assess the utility of biomarkers for monitoring the effects of enzyme replacement therapy (ERT). Design and methods: Forty treatment-naive Gaucher patients were studied. 27/40 GP were put on ERT and monitored every 6 months. Results: The baseline median values of Chito, TACP, ACE and ferritin were highly elevated in GP: 10216 nmol/mL/h, 26.1 U/L, 253 U/L, 515 mu g/L, and 555 mu g/L, respectively. The only significant difference between mild and moderate GP subgroups is observed for Chito activity (p=0.0116). During ERT, Chito showed the steepest decrease in regard to TACP and ACE, mainly within the first year (71.4%). Conclusions: Among these biomarkers, Chito proved to be the most useful biomarker for diagnosing GD and monitoring the ERT.en
dc.publisherPergamon-Elsevier Science Ltd, Oxford
dc.relationinfo:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/175036/RS//
dc.rightsrestrictedAccess
dc.sourceClinical Biochemistry
dc.subjectAcid phosphataseen
dc.subjectAngiotensin converting enzymeen
dc.subjectChitotriosidaseen
dc.subjectEnzyme replacement therapyen
dc.subjectFerritinen
dc.subjectGaucher diseaseen
dc.titleBiomarkers in Serbian patients with Gaucher diseaseen
dc.typearticle
dc.rights.licenseARR
dcterms.abstractПетаков, Милан; Игњатовић, Светлана; Митровић, Мирјана; Ђорђевић, Маја; Родић, Предраг; Шумарац, Зорица; Мајкић-Сингх, Нада; Дајак, Маријана; Голубовић, Милка; Сувајдзић, Нада; Јанић, Драгана;
dc.citation.volume44
dc.citation.issue12
dc.citation.spage950
dc.citation.epage954
dc.citation.other44(12): 950-954
dc.citation.rankM22
dc.identifier.wos000293043400002
dc.identifier.doi10.1016/j.clinbiochem.2011.05.016
dc.identifier.pmid21640089
dc.identifier.scopus2-s2.0-79960377766
dc.identifier.rcubconv_2482
dc.type.versionpublishedVersion


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