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N-terminal pro-b-type natriuretic peptide in patients with hypertensive heart disease

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2011
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Authors
Pejović, Janko
Ignjatović, Svetlana
Dajak, Marijana
Majkić-Singh, Nada
Vučinić, Žarko
Article (Published version)
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Abstract
Patients with hypertensive heart disease have elevated concentrations of N-terminal pro-B-type natriuretic peptide (NT-proBNP). The aim of our study was to evaluate NT-proBNP in patients with long-standing hypertension and in patients with signs of hypertensive cardiomyopathy. The study included three groups of 50 subjects: healthy persons (Control Group), patients with hypertension and normal left ventricular systolic function (Group 1) and patients with long-standing hypertension and signs of hypertensive cardiomyopathy with impaired left ventricular systolic function (Group 2). Our results show a very good correlation (Pearson's test) between NT-proBNP in Group 1 and Group 2 and C-reactive protein (Group 1: r = 0.8424; Group 2: r = 0.6650), systolic blood pressure (Group 1: r = 0.7213; Group 2: r = 0.4856), diastolic blood pressure (Group 1: r = 0.4282; Group 2: r = 0.3989) and ejection fraction (Group 1: r = -0.7390; Group 2: r = 0.9111). ROC analysis revealed that the AUC between ...the Control Group and Group 1 for NT-proBNP (0.912) was not significantly different (p>0.05) from the AUC for systolic (0.924) and diastolic pressure (0.937). A cut-off value for NT-proBNP of 5.89 pmol/L can be used to reliably distinguish patients of Group 1 from the Control Group, and a cut-off value of 21.67 pmol/L reliably separates patients from Group 1 and Group 2 (in both cases, the AUC is 1.000). Patients in Group 2 who belonged to the II and III New York Heart Association (NYHA) class had significantly higher levels of NT-proBNP than those in NYHA class I (ANOVA test, p=0.001). These data suggest that NT-proBNP is a useful biomarker for distinguishing patients with long-standing hypertension who are at risk of heart failure, allowing optimization and proper treatment of these patients.

Keywords:
N-terminal pro-B-type natriuretic peptide / hypertensive heart disease / hypertensive cardiomyopathy
Source:
Journal of Medical Biochemistry, 2011, 30, 3, 244-249
Publisher:
  • Društvo medicinskih biohemičara Srbije, Beograd i Versita
Projects:
  • Biomarkers of organ damage and dysfunction (RS-175036)

DOI: 10.2478/v10011-011-0016-4

ISSN: 1452-8258

WoS: 000292419300010

Scopus: 2-s2.0-79959535160
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URI
http://farfar.pharmacy.bg.ac.rs/handle/123456789/1557
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  • Radovi istraživača / Researchers’ publications
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Pharmacy

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