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dc.creatorPetrović, Sandra
dc.creatorLeskovac, Andreja
dc.creatorKotur-Stevuljević, Jelena
dc.creatorJoksić, Jelena
dc.creatorGuc-Scekić, Marija
dc.creatorVujić, Dragana
dc.creatorJoksić, Gordana
dc.date.accessioned2019-09-02T11:25:33Z
dc.date.available2019-09-02T11:25:33Z
dc.date.issued2011
dc.identifier.issn1431-6730
dc.identifier.urihttp://farfar.pharmacy.bg.ac.rs/handle/123456789/1563
dc.description.abstractFanconi anemia (FA) is a rare cancer-prone genetic disorder characterized by progressive bone marrow failure, chromosomal instability and redox abnormalities. There is much biochemical and genetic data, which strongly suggest that FA cells experience increased oxidative stress. The present study was designed to elucidate if differences in oxidant state exist between control, idiopathic bone marrow failure (idBMF) and FA cells, and to analyze oxidant state of cells in FA heterozygous carriers as well. The results of the present study confirm an in vivo prooxidant state of FA cells and clearly indicate that FA patients can be distinguished from idBMF patients based on the oxidant state of cells. Female carriers of FA mutation also exhibited hallmarks of an in vivo prooxidant state behaving in a similar manner as FA patients. On the other hand, the oxidant state of cells in FA male carriers and idBMF families failed to show any significant difference vs. controls. We demonstrate that the altered oxidant state influences susceptibility of cells to apoptosis in both FA patients and female carriers. The results highlight the need for further research of the possible role of mitochondrial inheritance in the pathogenesis of FA.en
dc.publisherWalter de Gruyter & Co, Berlin
dc.relationinfo:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/173046/RS//
dc.rightsrestrictedAccess
dc.sourceBiological Chemistry
dc.subjectapoptosisen
dc.subjectcatalaseen
dc.subjectextracellular superoxide dismutaseen
dc.subjectFanconi anemiaen
dc.subjectoxidative stressen
dc.titleGender-related differences in the oxidant state of cells in Fanconi anemia heterozygotesen
dc.typearticle
dc.rights.licenseARR
dcterms.abstractЈоксић, Јелена; Јоксић, Гордана; Петровић, Сандра; Гуц-Сцекић, Марија; Вујић, Драгана; Котур-Стевуљевић, Јелена; Лесковац, Aндреја;
dc.citation.volume392
dc.citation.issue7
dc.citation.spage625
dc.citation.epage632
dc.citation.other392(7): 625-632
dc.citation.rankM22
dc.identifier.wos000291533300005
dc.identifier.doi10.1515/BC.2011.064
dc.identifier.pmid21619480
dc.identifier.scopus2-s2.0-79959441251
dc.identifier.rcubconv_2454
dc.type.versionpublishedVersion


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