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dc.creatorAntić, Dušan
dc.creatorFilipić, Slavica
dc.creatorIvković, Branka
dc.creatorNikolić, Katarina
dc.creatorAgbaba, Danica
dc.date.accessioned2019-09-02T11:25:34Z
dc.date.available2019-09-02T11:25:34Z
dc.date.issued2011
dc.identifier.issn1233-2356
dc.identifier.urihttp://farfar.pharmacy.bg.ac.rs/handle/123456789/1564
dc.description.abstractA simple and rapid TLC method using beta-cyclodextrin as a chiral mobile phase additive (CMPA) was developed for direct separation of S-clopidogrel and its impurity R-clopidogrel. The influence of different factors (stationary phases, organic modifiers, chiral selectors and their concentrations in the mobile phase, and optimal saturation time of the chamber) on enantioseparation was studied. The best resolution of clopidogrel enantiomers was achieved on Polygram (R) cel 300 Ac-10% plates using isopropanol-0.5 mM beta-cyclodextrin (6: 4, v/v) as mobile phase in TLC chamber previously equilibrated with the mobile phase for 20 min. The spots were detected under UV light and using iodine vapours. The method enables rapid separation of clopidogrel enantiomers and can be successfully used in control of stereoselective synthesis of clopidogrel and in control of its purity. Finally, the molecular modelling of the inclusion complexes between the analytes and alpha-, beta-, and gamma-cyclodextrin was performed to investigate the mechanism of the enantiorecognition.en
dc.publisherAkademiai Kiado Rt, Budapest
dc.relationinfo:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/172033/RS//
dc.rightsrestrictedAccess
dc.sourceActa Chromatographica
dc.subjectclopidogrelen
dc.subjectenantioseparationen
dc.subjectchiral impurityen
dc.subjectTLCen
dc.subjectbeta-cyclodextrinen
dc.titleDirect Separation of Clopidogrel Enantiomers by Reverse-Phase Planar Chromatography Method Using beta-Cyclodextrin as a Chiral Mobile Phase Additiveen
dc.typearticle
dc.rights.licenseARR
dcterms.abstractAгбаба, Даница; Ивковић, Бранка; Aнтић, Д.; Николић, Катарина; Филипић, Славица;
dc.citation.volume23
dc.citation.issue2
dc.citation.spage235
dc.citation.epage245
dc.citation.other23(2): 235-245
dc.citation.rankM23
dc.identifier.wos000291343100004
dc.identifier.doi10.1556/AChrom.23.2011.2.4
dc.identifier.scopus2-s2.0-79958847889
dc.identifier.rcubconv_2441
dc.type.versionpublishedVersion


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