Butyrylcholinesterase activity in young men and women: Association with cardiovascular risk factors

Abstract

Objective: We investigated the relationship between butyrylcholinesterase (BuChE) and cardiovascular risk factors in young male and female. Design and methods: The study comprised 1512 healthy subjects, 18-25 years of age. In fasting sera the concentrations of BuChE and cardiovascular risk factors were estimated. Results: Analysis of variance indicated significant increase in body mass index (BMI), total cholesterol (TC), triglycerides (TG), low-density lipoproteins (LDL) (p lt 0.05) and albumin (p lt 0.001) with BuChE activity increment in males. In females glucose and albumin (p lt 0.05) increased with BuChE activity. Negative but not significant correlation between BuChE and high-density lipoprotein cholesterol (HDL-C) was detected for both genders. Conclusion: The tendency towards overweight in young male could explain our results on BMI as an independent risk factor for higher BuChE in young male. Glucose as an independent risk factor for higher BuChE activity in females indicates that BuChE may be a predictor of diabetes.