Objective: Dyslipidemia is commonly seen in patients with end-stage renal disease (ESRD). This prospective study investigates whether small-sized high-density lipoprotein (HDL) particles alone or in combination with high sensitivity C-reactive protein (hsCRP) are independent determinants of ESRD mortality. Design and methods: We performed 36 months follow-up study in 122 haemodialysis (HD) patients. HDL size and subclass distribution were determined by gradient gel electrophoresis. Baseline characteristics of the patients were evaluated for the prediction of mortality. Results: Cox regressions analysis showed that patients with small-sized HDL particles had 2.8-fold higher risk of lethal outcome (P lt 0.05). Concomitant presence of small-sized HDL particles and increased hsCRP concentration were significantly associated with reduced survival rate (HR = 3.907; P lt 0.05). Observed relationships persisted after adjustment for serum lipid and lipoprotein concentrations. Conclusions: Our r...esults indicate that small-sized HDL particles alone and combined with elevated hsCRP concentrations are independent predictors of reduced survival in HD patients.
TY - JOUR
AU - Vekić, Jelena
AU - Zeljković, Aleksandra
AU - Bogavac-Stanojević, Nataša
AU - Jelić-Ivanović, Zorana
AU - Spasojević-Kalimanovska, Vesna
AU - Simić-Ogrizović, Sanja
AU - Dopsaj, Violeta
AU - Spasić, Slavica
PY - 2011
UR - https://farfar.pharmacy.bg.ac.rs/handle/123456789/1569
AB - Objective: Dyslipidemia is commonly seen in patients with end-stage renal disease (ESRD). This prospective study investigates whether small-sized high-density lipoprotein (HDL) particles alone or in combination with high sensitivity C-reactive protein (hsCRP) are independent determinants of ESRD mortality. Design and methods: We performed 36 months follow-up study in 122 haemodialysis (HD) patients. HDL size and subclass distribution were determined by gradient gel electrophoresis. Baseline characteristics of the patients were evaluated for the prediction of mortality. Results: Cox regressions analysis showed that patients with small-sized HDL particles had 2.8-fold higher risk of lethal outcome (P lt 0.05). Concomitant presence of small-sized HDL particles and increased hsCRP concentration were significantly associated with reduced survival rate (HR = 3.907; P lt 0.05). Observed relationships persisted after adjustment for serum lipid and lipoprotein concentrations. Conclusions: Our results indicate that small-sized HDL particles alone and combined with elevated hsCRP concentrations are independent predictors of reduced survival in HD patients.
PB - Pergamon-Elsevier Science Ltd, Oxford
T2 - Clinical Biochemistry
T1 - Cox proportional hazard model analysis of survival in end-stage renal disease patients with small-sized high-density lipoprotein particles
VL - 44
IS - 8-9
SP - 635
EP - 641
DO - 10.1016/j.clinbiochem.2011.02.002
ER -
@article{
author = "Vekić, Jelena and Zeljković, Aleksandra and Bogavac-Stanojević, Nataša and Jelić-Ivanović, Zorana and Spasojević-Kalimanovska, Vesna and Simić-Ogrizović, Sanja and Dopsaj, Violeta and Spasić, Slavica",
year = "2011",
abstract = "Objective: Dyslipidemia is commonly seen in patients with end-stage renal disease (ESRD). This prospective study investigates whether small-sized high-density lipoprotein (HDL) particles alone or in combination with high sensitivity C-reactive protein (hsCRP) are independent determinants of ESRD mortality. Design and methods: We performed 36 months follow-up study in 122 haemodialysis (HD) patients. HDL size and subclass distribution were determined by gradient gel electrophoresis. Baseline characteristics of the patients were evaluated for the prediction of mortality. Results: Cox regressions analysis showed that patients with small-sized HDL particles had 2.8-fold higher risk of lethal outcome (P lt 0.05). Concomitant presence of small-sized HDL particles and increased hsCRP concentration were significantly associated with reduced survival rate (HR = 3.907; P lt 0.05). Observed relationships persisted after adjustment for serum lipid and lipoprotein concentrations. Conclusions: Our results indicate that small-sized HDL particles alone and combined with elevated hsCRP concentrations are independent predictors of reduced survival in HD patients.",
publisher = "Pergamon-Elsevier Science Ltd, Oxford",
journal = "Clinical Biochemistry",
title = "Cox proportional hazard model analysis of survival in end-stage renal disease patients with small-sized high-density lipoprotein particles",
volume = "44",
number = "8-9",
pages = "635-641",
doi = "10.1016/j.clinbiochem.2011.02.002"
}
Vekić, J., Zeljković, A., Bogavac-Stanojević, N., Jelić-Ivanović, Z., Spasojević-Kalimanovska, V., Simić-Ogrizović, S., Dopsaj, V.,& Spasić, S.. (2011). Cox proportional hazard model analysis of survival in end-stage renal disease patients with small-sized high-density lipoprotein particles. in Clinical Biochemistry
Pergamon-Elsevier Science Ltd, Oxford., 44(8-9), 635-641.
https://doi.org/10.1016/j.clinbiochem.2011.02.002
Vekić J, Zeljković A, Bogavac-Stanojević N, Jelić-Ivanović Z, Spasojević-Kalimanovska V, Simić-Ogrizović S, Dopsaj V, Spasić S. Cox proportional hazard model analysis of survival in end-stage renal disease patients with small-sized high-density lipoprotein particles. in Clinical Biochemistry. 2011;44(8-9):635-641.
doi:10.1016/j.clinbiochem.2011.02.002 .
Vekić, Jelena, Zeljković, Aleksandra, Bogavac-Stanojević, Nataša, Jelić-Ivanović, Zorana, Spasojević-Kalimanovska, Vesna, Simić-Ogrizović, Sanja, Dopsaj, Violeta, Spasić, Slavica, "Cox proportional hazard model analysis of survival in end-stage renal disease patients with small-sized high-density lipoprotein particles" in Clinical Biochemistry, 44, no. 8-9 (2011):635-641,
https://doi.org/10.1016/j.clinbiochem.2011.02.002 . .
