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Cox proportional hazard model analysis of survival in end-stage renal disease patients with small-sized high-density lipoprotein particles
dc.creator | Vekić, Jelena | |
dc.creator | Zeljković, Aleksandra | |
dc.creator | Bogavac-Stanojević, Nataša | |
dc.creator | Jelić-Ivanović, Zorana | |
dc.creator | Spasojević-Kalimanovska, Vesna | |
dc.creator | Simić-Ogrizović, Sanja | |
dc.creator | Dopsaj, Violeta | |
dc.creator | Spasić, Slavica | |
dc.date.accessioned | 2019-09-02T11:25:41Z | |
dc.date.available | 2019-09-02T11:25:41Z | |
dc.date.issued | 2011 | |
dc.identifier.issn | 0009-9120 | |
dc.identifier.uri | https://farfar.pharmacy.bg.ac.rs/handle/123456789/1569 | |
dc.description.abstract | Objective: Dyslipidemia is commonly seen in patients with end-stage renal disease (ESRD). This prospective study investigates whether small-sized high-density lipoprotein (HDL) particles alone or in combination with high sensitivity C-reactive protein (hsCRP) are independent determinants of ESRD mortality. Design and methods: We performed 36 months follow-up study in 122 haemodialysis (HD) patients. HDL size and subclass distribution were determined by gradient gel electrophoresis. Baseline characteristics of the patients were evaluated for the prediction of mortality. Results: Cox regressions analysis showed that patients with small-sized HDL particles had 2.8-fold higher risk of lethal outcome (P lt 0.05). Concomitant presence of small-sized HDL particles and increased hsCRP concentration were significantly associated with reduced survival rate (HR = 3.907; P lt 0.05). Observed relationships persisted after adjustment for serum lipid and lipoprotein concentrations. Conclusions: Our results indicate that small-sized HDL particles alone and combined with elevated hsCRP concentrations are independent predictors of reduced survival in HD patients. | en |
dc.publisher | Pergamon-Elsevier Science Ltd, Oxford | |
dc.relation | info:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/175035/RS// | |
dc.rights | restrictedAccess | |
dc.source | Clinical Biochemistry | |
dc.subject | Renal disease | en |
dc.subject | Haemodialysis | en |
dc.subject | HDL size | en |
dc.subject | Inflammation | en |
dc.subject | C-reactive protein | en |
dc.title | Cox proportional hazard model analysis of survival in end-stage renal disease patients with small-sized high-density lipoprotein particles | en |
dc.type | article | |
dc.rights.license | ARR | |
dcterms.abstract | Спасић, Славица; Јелић-Ивановић, Зорана; Спасојевић-Калимановска, Весна; Зељковић, Aлександра; Допсај, Виолета; Симић-Огризовић, Сања; Векић, Јелена; Богавац-Станојевић, Наташа; | |
dc.citation.volume | 44 | |
dc.citation.issue | 8-9 | |
dc.citation.spage | 635 | |
dc.citation.epage | 641 | |
dc.citation.other | 44(8-9): 635-641 | |
dc.citation.rank | M22 | |
dc.identifier.wos | 000291081400012 | |
dc.identifier.doi | 10.1016/j.clinbiochem.2011.02.002 | |
dc.identifier.pmid | 21320480 | |
dc.identifier.scopus | 2-s2.0-79955794222 | |
dc.type.version | publishedVersion |