Paclitaxel as an anticancer agent: isolation, activity, synthesis and stability

2011
Authors
Nikolić, Vesna D.Savić, Ivan

Savić, Ivana

Nikolić, Ljubiša
Stanković, Mihajlo
Marinković, Valentina

Article (Published version)

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Show full item recordAbstract
Paclitaxel is isolated from the Pacific yew. It can be obtained from the European yew, but only after chemical modification of the isolated compound by a semi-synthesis procedure. The procedure for total synthesis of paclitaxel is very complicated, involving multiple steps, and the yields of paclitaxel are meagre. This substance is also a metabolite of certain kinds of fungus. The microbiological pathway for producing paclitaxel compared with isolation from plant material involves shorter procuction times but a small yield. Cyclodextrins are usually used for improving the solubility of paclitaxel in aqueous media, with polymeric and other substances added. Paclitaxel has anticancer activity and use for preparing the formulations intravenously administrated to patients with tumors. The paclitaxel concentration in these formulations is determined using validated HPLC methods.
Keywords:
Paclitaxel / Isolation / Activity / Synthesis / ComplexationSource:
Central European Journal of Medicine, 2011, 6, 5, 527-536Publisher:
- Versita, Warsaw
Funding / projects:
DOI: 10.2478/s11536-011-0074-5
ISSN: 1895-1058
WoS: 000293708800001
Scopus: 2-s2.0-81355161459
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PharmacyTY - JOUR AU - Nikolić, Vesna D. AU - Savić, Ivan AU - Savić, Ivana AU - Nikolić, Ljubiša AU - Stanković, Mihajlo AU - Marinković, Valentina PY - 2011 UR - https://farfar.pharmacy.bg.ac.rs/handle/123456789/1573 AB - Paclitaxel is isolated from the Pacific yew. It can be obtained from the European yew, but only after chemical modification of the isolated compound by a semi-synthesis procedure. The procedure for total synthesis of paclitaxel is very complicated, involving multiple steps, and the yields of paclitaxel are meagre. This substance is also a metabolite of certain kinds of fungus. The microbiological pathway for producing paclitaxel compared with isolation from plant material involves shorter procuction times but a small yield. Cyclodextrins are usually used for improving the solubility of paclitaxel in aqueous media, with polymeric and other substances added. Paclitaxel has anticancer activity and use for preparing the formulations intravenously administrated to patients with tumors. The paclitaxel concentration in these formulations is determined using validated HPLC methods. PB - Versita, Warsaw T2 - Central European Journal of Medicine T1 - Paclitaxel as an anticancer agent: isolation, activity, synthesis and stability VL - 6 IS - 5 SP - 527 EP - 536 DO - 10.2478/s11536-011-0074-5 ER -
@article{ author = "Nikolić, Vesna D. and Savić, Ivan and Savić, Ivana and Nikolić, Ljubiša and Stanković, Mihajlo and Marinković, Valentina", year = "2011", abstract = "Paclitaxel is isolated from the Pacific yew. It can be obtained from the European yew, but only after chemical modification of the isolated compound by a semi-synthesis procedure. The procedure for total synthesis of paclitaxel is very complicated, involving multiple steps, and the yields of paclitaxel are meagre. This substance is also a metabolite of certain kinds of fungus. The microbiological pathway for producing paclitaxel compared with isolation from plant material involves shorter procuction times but a small yield. Cyclodextrins are usually used for improving the solubility of paclitaxel in aqueous media, with polymeric and other substances added. Paclitaxel has anticancer activity and use for preparing the formulations intravenously administrated to patients with tumors. The paclitaxel concentration in these formulations is determined using validated HPLC methods.", publisher = "Versita, Warsaw", journal = "Central European Journal of Medicine", title = "Paclitaxel as an anticancer agent: isolation, activity, synthesis and stability", volume = "6", number = "5", pages = "527-536", doi = "10.2478/s11536-011-0074-5" }
Nikolić, V. D., Savić, I., Savić, I., Nikolić, L., Stanković, M.,& Marinković, V.. (2011). Paclitaxel as an anticancer agent: isolation, activity, synthesis and stability. in Central European Journal of Medicine Versita, Warsaw., 6(5), 527-536. https://doi.org/10.2478/s11536-011-0074-5
Nikolić VD, Savić I, Savić I, Nikolić L, Stanković M, Marinković V. Paclitaxel as an anticancer agent: isolation, activity, synthesis and stability. in Central European Journal of Medicine. 2011;6(5):527-536. doi:10.2478/s11536-011-0074-5 .
Nikolić, Vesna D., Savić, Ivan, Savić, Ivana, Nikolić, Ljubiša, Stanković, Mihajlo, Marinković, Valentina, "Paclitaxel as an anticancer agent: isolation, activity, synthesis and stability" in Central European Journal of Medicine, 6, no. 5 (2011):527-536, https://doi.org/10.2478/s11536-011-0074-5 . .