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Paclitaxel as an anticancer agent: isolation, activity, synthesis and stability

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2011
1571.pdf (508.1Kb)
Authors
Nikolić, Vesna D.
Savić, Ivan
Savić, Ivana
Nikolić, Ljubiša
Stanković, Mihajlo
Marinković, Valentina
Article (Published version)
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Abstract
Paclitaxel is isolated from the Pacific yew. It can be obtained from the European yew, but only after chemical modification of the isolated compound by a semi-synthesis procedure. The procedure for total synthesis of paclitaxel is very complicated, involving multiple steps, and the yields of paclitaxel are meagre. This substance is also a metabolite of certain kinds of fungus. The microbiological pathway for producing paclitaxel compared with isolation from plant material involves shorter procuction times but a small yield. Cyclodextrins are usually used for improving the solubility of paclitaxel in aqueous media, with polymeric and other substances added. Paclitaxel has anticancer activity and use for preparing the formulations intravenously administrated to patients with tumors. The paclitaxel concentration in these formulations is determined using validated HPLC methods.
Keywords:
Paclitaxel / Isolation / Activity / Synthesis / Complexation
Source:
Central European Journal of Medicine, 2011, 6, 5, 527-536
Publisher:
  • Versita, Warsaw
Funding / projects:
  • Plants and synthetic bioactive products of new generation (RS-34012)

DOI: 10.2478/s11536-011-0074-5

ISSN: 1895-1058

WoS: 000293708800001

Scopus: 2-s2.0-81355161459
[ Google Scholar ]
19
14
URI
https://farfar.pharmacy.bg.ac.rs/handle/123456789/1573
Collections
  • Radovi istraživača / Researchers’ publications
Institution/Community
Pharmacy
TY  - JOUR
AU  - Nikolić, Vesna D.
AU  - Savić, Ivan
AU  - Savić, Ivana
AU  - Nikolić, Ljubiša
AU  - Stanković, Mihajlo
AU  - Marinković, Valentina
PY  - 2011
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/1573
AB  - Paclitaxel is isolated from the Pacific yew. It can be obtained from the European yew, but only after chemical modification of the isolated compound by a semi-synthesis procedure. The procedure for total synthesis of paclitaxel is very complicated, involving multiple steps, and the yields of paclitaxel are meagre. This substance is also a metabolite of certain kinds of fungus. The microbiological pathway for producing paclitaxel compared with isolation from plant material involves shorter procuction times but a small yield. Cyclodextrins are usually used for improving the solubility of paclitaxel in aqueous media, with polymeric and other substances added. Paclitaxel has anticancer activity and use for preparing the formulations intravenously administrated to patients with tumors. The paclitaxel concentration in these formulations is determined using validated HPLC methods.
PB  - Versita, Warsaw
T2  - Central European Journal of Medicine
T1  - Paclitaxel as an anticancer agent: isolation, activity, synthesis and stability
VL  - 6
IS  - 5
SP  - 527
EP  - 536
DO  - 10.2478/s11536-011-0074-5
ER  - 
@article{
author = "Nikolić, Vesna D. and Savić, Ivan and Savić, Ivana and Nikolić, Ljubiša and Stanković, Mihajlo and Marinković, Valentina",
year = "2011",
abstract = "Paclitaxel is isolated from the Pacific yew. It can be obtained from the European yew, but only after chemical modification of the isolated compound by a semi-synthesis procedure. The procedure for total synthesis of paclitaxel is very complicated, involving multiple steps, and the yields of paclitaxel are meagre. This substance is also a metabolite of certain kinds of fungus. The microbiological pathway for producing paclitaxel compared with isolation from plant material involves shorter procuction times but a small yield. Cyclodextrins are usually used for improving the solubility of paclitaxel in aqueous media, with polymeric and other substances added. Paclitaxel has anticancer activity and use for preparing the formulations intravenously administrated to patients with tumors. The paclitaxel concentration in these formulations is determined using validated HPLC methods.",
publisher = "Versita, Warsaw",
journal = "Central European Journal of Medicine",
title = "Paclitaxel as an anticancer agent: isolation, activity, synthesis and stability",
volume = "6",
number = "5",
pages = "527-536",
doi = "10.2478/s11536-011-0074-5"
}
Nikolić, V. D., Savić, I., Savić, I., Nikolić, L., Stanković, M.,& Marinković, V.. (2011). Paclitaxel as an anticancer agent: isolation, activity, synthesis and stability. in Central European Journal of Medicine
Versita, Warsaw., 6(5), 527-536.
https://doi.org/10.2478/s11536-011-0074-5
Nikolić VD, Savić I, Savić I, Nikolić L, Stanković M, Marinković V. Paclitaxel as an anticancer agent: isolation, activity, synthesis and stability. in Central European Journal of Medicine. 2011;6(5):527-536.
doi:10.2478/s11536-011-0074-5 .
Nikolić, Vesna D., Savić, Ivan, Savić, Ivana, Nikolić, Ljubiša, Stanković, Mihajlo, Marinković, Valentina, "Paclitaxel as an anticancer agent: isolation, activity, synthesis and stability" in Central European Journal of Medicine, 6, no. 5 (2011):527-536,
https://doi.org/10.2478/s11536-011-0074-5 . .

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