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dc.creatorNikolić, Vesna D.
dc.creatorSavić, Ivan
dc.creatorSavić, Ivana
dc.creatorNikolić, Ljubiša
dc.creatorStanković, Mihajlo
dc.creatorMarinković, Valentina
dc.date.accessioned2019-09-02T11:25:48Z
dc.date.available2019-09-02T11:25:48Z
dc.date.issued2011
dc.identifier.issn1895-1058
dc.identifier.urihttps://farfar.pharmacy.bg.ac.rs/handle/123456789/1573
dc.description.abstractPaclitaxel is isolated from the Pacific yew. It can be obtained from the European yew, but only after chemical modification of the isolated compound by a semi-synthesis procedure. The procedure for total synthesis of paclitaxel is very complicated, involving multiple steps, and the yields of paclitaxel are meagre. This substance is also a metabolite of certain kinds of fungus. The microbiological pathway for producing paclitaxel compared with isolation from plant material involves shorter procuction times but a small yield. Cyclodextrins are usually used for improving the solubility of paclitaxel in aqueous media, with polymeric and other substances added. Paclitaxel has anticancer activity and use for preparing the formulations intravenously administrated to patients with tumors. The paclitaxel concentration in these formulations is determined using validated HPLC methods.en
dc.publisherVersita, Warsaw
dc.relationinfo:eu-repo/grantAgreement/MESTD/Technological Development (TD or TR)/34012/RS//
dc.rightsopenAccess
dc.sourceCentral European Journal of Medicine
dc.subjectPaclitaxelen
dc.subjectIsolationen
dc.subjectActivityen
dc.subjectSynthesisen
dc.subjectComplexationen
dc.titlePaclitaxel as an anticancer agent: isolation, activity, synthesis and stabilityen
dc.typearticle
dc.rights.licenseARR
dcterms.abstractНиколић, Весна Д.; Савић, Иван М.; Станковић, Михајло; Савић, Ивана М.; Николић, Љубиша; Маринковић, Валентина;
dc.citation.volume6
dc.citation.issue5
dc.citation.spage527
dc.citation.epage536
dc.citation.other6(5): 527-536
dc.citation.rankM23
dc.identifier.wos000293708800001
dc.identifier.doi10.2478/s11536-011-0074-5
dc.identifier.scopus2-s2.0-81355161459
dc.identifier.fulltexthttps://farfar.pharmacy.bg.ac.rs//bitstream/id/421/1571.pdf
dc.identifier.rcubconv_2487
dc.type.versionpublishedVersion


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