Arbutus unedo leaf is used traditionally for gastrointestinal complaints. Ethanol extracts from Arbutus unedo collected in both Montenegro (AuM) and Greece (AuG) were found to decrease the ileal basal tonus, with AuG producing a significantly higher (p lt 0.05) reduction in contractile response to acetylcholine. AuM and AuG relaxed 80 mM K(+) induced contractions and shifted the Ca concentration-response curves to the right, similar to that caused by verapamil, suggesting that the spasmolytic effect was induced through calcium channel inhibition. The antioxidant activity of AuM and AuG and the phenolic content of the extracts and dry plant material were studied, and both extracts were found to possess considerable antioxidant properties. AuG showed a stronger in vitro antioxidative activity in the DPPH assay and in the TBA test. Polyphenol, tannin and flavonoid levels were higher in AuG, supporting the more potent spasmolytic and antioxidative effects, whereas the arbutin content was... higher in dry plant material collected in Montenegro. Copyright
TY - JOUR
AU - Pavlović, Dragana R.
AU - Branković, Suzana
AU - Kovačević, Nada
AU - Kitić, Dušanka
AU - Veljković, Slavimir
PY - 2011
UR - https://farfar.pharmacy.bg.ac.rs/handle/123456789/1574
AB - Arbutus unedo leaf is used traditionally for gastrointestinal complaints. Ethanol extracts from Arbutus unedo collected in both Montenegro (AuM) and Greece (AuG) were found to decrease the ileal basal tonus, with AuG producing a significantly higher (p lt 0.05) reduction in contractile response to acetylcholine. AuM and AuG relaxed 80 mM K(+) induced contractions and shifted the Ca concentration-response curves to the right, similar to that caused by verapamil, suggesting that the spasmolytic effect was induced through calcium channel inhibition. The antioxidant activity of AuM and AuG and the phenolic content of the extracts and dry plant material were studied, and both extracts were found to possess considerable antioxidant properties. AuG showed a stronger in vitro antioxidative activity in the DPPH assay and in the TBA test. Polyphenol, tannin and flavonoid levels were higher in AuG, supporting the more potent spasmolytic and antioxidative effects, whereas the arbutin content was higher in dry plant material collected in Montenegro. Copyright
PB - Wiley-Blackwell, Malden
T2 - Phytotherapy Research
T1 - Comparative Study of Spasmolytic Properties, Antioxidant Activity and Phenolic Content of Arbutus unedo from Montenegro and Greece
VL - 25
IS - 5
SP - 749
EP - 754
DO - 10.1002/ptr.3460
ER -
@article{
author = "Pavlović, Dragana R. and Branković, Suzana and Kovačević, Nada and Kitić, Dušanka and Veljković, Slavimir",
year = "2011",
abstract = "Arbutus unedo leaf is used traditionally for gastrointestinal complaints. Ethanol extracts from Arbutus unedo collected in both Montenegro (AuM) and Greece (AuG) were found to decrease the ileal basal tonus, with AuG producing a significantly higher (p lt 0.05) reduction in contractile response to acetylcholine. AuM and AuG relaxed 80 mM K(+) induced contractions and shifted the Ca concentration-response curves to the right, similar to that caused by verapamil, suggesting that the spasmolytic effect was induced through calcium channel inhibition. The antioxidant activity of AuM and AuG and the phenolic content of the extracts and dry plant material were studied, and both extracts were found to possess considerable antioxidant properties. AuG showed a stronger in vitro antioxidative activity in the DPPH assay and in the TBA test. Polyphenol, tannin and flavonoid levels were higher in AuG, supporting the more potent spasmolytic and antioxidative effects, whereas the arbutin content was higher in dry plant material collected in Montenegro. Copyright",
publisher = "Wiley-Blackwell, Malden",
journal = "Phytotherapy Research",
title = "Comparative Study of Spasmolytic Properties, Antioxidant Activity and Phenolic Content of Arbutus unedo from Montenegro and Greece",
volume = "25",
number = "5",
pages = "749-754",
doi = "10.1002/ptr.3460"
}
Pavlović, D. R., Branković, S., Kovačević, N., Kitić, D.,& Veljković, S.. (2011). Comparative Study of Spasmolytic Properties, Antioxidant Activity and Phenolic Content of Arbutus unedo from Montenegro and Greece. in Phytotherapy Research
Wiley-Blackwell, Malden., 25(5), 749-754.
https://doi.org/10.1002/ptr.3460
Pavlović DR, Branković S, Kovačević N, Kitić D, Veljković S. Comparative Study of Spasmolytic Properties, Antioxidant Activity and Phenolic Content of Arbutus unedo from Montenegro and Greece. in Phytotherapy Research. 2011;25(5):749-754.
doi:10.1002/ptr.3460 .
Pavlović, Dragana R., Branković, Suzana, Kovačević, Nada, Kitić, Dušanka, Veljković, Slavimir, "Comparative Study of Spasmolytic Properties, Antioxidant Activity and Phenolic Content of Arbutus unedo from Montenegro and Greece" in Phytotherapy Research, 25, no. 5 (2011):749-754,
https://doi.org/10.1002/ptr.3460 . .
