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dc.creatorPavlović, Dragana R.
dc.creatorBranković, Suzana
dc.creatorKovačević, Nada
dc.creatorKitić, Dušanka
dc.creatorVeljković, Slavimir
dc.date.accessioned2019-09-02T11:25:48Z
dc.date.available2019-09-02T11:25:48Z
dc.date.issued2011
dc.identifier.issn0951-418X
dc.identifier.urihttp://farfar.pharmacy.bg.ac.rs/handle/123456789/1574
dc.description.abstractArbutus unedo leaf is used traditionally for gastrointestinal complaints. Ethanol extracts from Arbutus unedo collected in both Montenegro (AuM) and Greece (AuG) were found to decrease the ileal basal tonus, with AuG producing a significantly higher (p lt 0.05) reduction in contractile response to acetylcholine. AuM and AuG relaxed 80 mM K(+) induced contractions and shifted the Ca concentration-response curves to the right, similar to that caused by verapamil, suggesting that the spasmolytic effect was induced through calcium channel inhibition. The antioxidant activity of AuM and AuG and the phenolic content of the extracts and dry plant material were studied, and both extracts were found to possess considerable antioxidant properties. AuG showed a stronger in vitro antioxidative activity in the DPPH assay and in the TBA test. Polyphenol, tannin and flavonoid levels were higher in AuG, supporting the more potent spasmolytic and antioxidative effects, whereas the arbutin content was higher in dry plant material collected in Montenegro. Copyrighten
dc.publisherWiley-Blackwell, Malden
dc.relationinfo:eu-repo/grantAgreement/MESTD/Integrated and Interdisciplinary Research (IIR or III)/41018/RS//
dc.rightsrestrictedAccess
dc.sourcePhytotherapy Research
dc.subjectArbutus unedoen
dc.subjectspasmolyticen
dc.subjectrat ileumen
dc.subjectantioxidanten
dc.subjectpolyphenolen
dc.subjectarbutinen
dc.titleComparative Study of Spasmolytic Properties, Antioxidant Activity and Phenolic Content of Arbutus unedo from Montenegro and Greeceen
dc.typearticle
dc.rights.licenseARR
dcterms.abstractПавловић, Драгана Р.; Китић, Душанка; Ковачевић, Нада; Вељковић, Славимир; Бранковић, Сузана;
dc.citation.volume25
dc.citation.issue5
dc.citation.spage749
dc.citation.epage754
dc.citation.other25(5): 749-754
dc.citation.rankM22
dc.identifier.wos000289999400018
dc.identifier.doi10.1002/ptr.3460
dc.identifier.pmid21438047
dc.identifier.scopus2-s2.0-79955533659
dc.identifier.rcubconv_2428
dc.type.versionpublishedVersion


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