Show simple item record

Biofarmaceutski aspekti interakcije ciprofloksacina i jona metala

dc.creatorParojčić, Jelena
dc.creatorStojković, Aleksandra
dc.creatorĐurić, Zorica
dc.date.accessioned2019-09-02T11:25:50Z
dc.date.available2019-09-02T11:25:50Z
dc.date.issued2011
dc.identifier.issn0004-1963
dc.identifier.urihttp://farfar.pharmacy.bg.ac.rs/handle/123456789/1576
dc.description.abstractThe ciprofloxacin - metallic ions interactions are well documented and described in the literature. In vivo studies show that ciprofloxacin bioavailability is reduced in the presence of metallic ions containing preparations. The results of in vitro studies are somewhat contradictory and indicate that highly soluble complexes, low soluble complexes, or no complexation may occur. Development of relevant simulation softwares resulted in the increased confidence and use of mathematical modeling and simulation in drug development and quality control. Advanced computer software's are now available which simulate drug product pharmacokinetic profile based on its physicochemical properties, formulation characteristics and physiological conditions in the gastrointestinal tract. The aim of the current work is to assess potential causes of reduced ciprofloxacin bioavailability when co-administered with metallic ion containing preparations through survey of the relevant in vivo, in vitro and in silico studies. The results obtained indicate that complex formation is one of the mechanisms involved in ciprofloxacin/metallic ion interaction and that other phenomena such as reduced solubility in the altered pH conditions and/or adsorption on the solid phase present in the intestinal lumen may also play a role. In order to accurately identify mechanisms responsible for drug interaction, thorough evaluation of all the available in vivo, in vitro and in silico data should be performed as part of the biopharmaceutical characterization.en
dc.description.abstractInterakcija ciprofloksacina i jona metala je dobro poznata i opisana u literaturi. Rezultati in vivo ispitivanja pokazuju da je biološka raspoloživost ciprofloksacina smanjena nakon istovremene primene preparata koji sadrže jone metala. Rezultati in vitro ispitivanja su kontradiktorni i pokazuju da mogu nastati kompleksi koji imaju veću rastvorljivost u odnosu na polazno jedinjenje, da nastali kompleksi imaju smanjenu rastvorljivost, kao i da građenje kompleksa izostaje. Sa razvojem računarskih programa koji omogućavaju predviđanja farmakokinetičkog profila na osnovu fizičko-hemijskih karakteristika lekovite supstance, karakteristika formulacije i fizioloških uslova u gastrointestinalnom traktu, matematičko modelovanje i simulacije zauzimaju sve važnije mesto u razvoju i proceni kvaliteta lekova. Cilj rada je da se kroz pregled rezultata in vivo, in vitro i in silico studija, analiziraju potencijalni uzroci promene u bioraspoloživosti ciprofloksacina primenjenog sa preparatima koji sadrže jone metala. Dobijeni rezultati ukazuju da građenje kompleksa predstavlja jedan od mehanizama uključenih u in vivo interakciju ciprofloksacina i jona metala i da drugi faktori, kao što je smanjena rastvorljivost usled promene pH i/ili adsorpcija na nerastvorene komponente čvrste faze, takođe mogu uticati. U okviru biofarmaceutske karakterizacije interakcija lekova, potrebno je uzeti u obzir rezultate in vivo, in vitro i in silico ispitivanja i sprovesti njihovu sveobuhvatnu analizu radi utvrđivanja mehanizma interakcije.sr
dc.publisherSavez farmaceutskih udruženja Srbije, Beograd
dc.relationinfo:eu-repo/grantAgreement/MESTD/Technological Development (TD or TR)/34007/RS//
dc.rightsopenAccess
dc.sourceArhiv za farmaciju
dc.subjectciprofloxacinen
dc.subjectinteractionen
dc.subjectcomplexationen
dc.subjectbioavailabilityen
dc.subjectsolubilityen
dc.subjectciprofloksacinsr
dc.subjectinterakcijasr
dc.subjectkompleksiranjesr
dc.subjectbioraspoloživostsr
dc.subjectrastvorljivostsr
dc.titleBiopharmaceutical aspects of ciprofloxacin interactions with metallic ionsen
dc.titleBiofarmaceutski aspekti interakcije ciprofloksacina i jona metalasr
dc.typearticle
dc.rights.licenseBY-SA
dcterms.abstractЂурић, Зорица; Стојковић, Aлександра; Паројчић, Јелена; Биофармацеутски аспекти интеракције ципрофлоксацина и јона метала; Биофармацеутски аспекти интеракције ципрофлоксацина и јона метала;
dc.citation.volume61
dc.citation.issue6
dc.citation.spage539
dc.citation.epage557
dc.citation.other61(6): 539-557
dc.citation.rankM53
dc.identifier.scopus2-s2.0-84858984955
dc.identifier.fulltexthttp://farfar.pharmacy.bg.ac.rs//bitstream/id/424/1574.pdf
dc.identifier.rcubconv_457
dc.type.versionpublishedVersion


Files in this item

Thumbnail

This item appears in the following Collection(s)

Show simple item record