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Protein-protein interactions in drug discovery

Protein-protein interakcije u razvoju novih lekova

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2011
1585.pdf (482.9Kb)
Authors
Ranđelović, Jelena
Savić, Vladimir
Article (Published version)
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Abstract
Protein-protein interactions form the basics of both physiological and pathological processes, which makes them important targets for drug discovery. Structural characteristics of protein complexes, features of their binding interfaces and theoretical foundations relevant to the design of small molecules modulators of protein interactions have been briefly described in this text. Several experimental methods applicable to the design of drugs acting on protein-protein interactions are listed. The research progress achieved so far is illustrated through several examples of successfully designed modulator molecules. Due to the extraordinary significance of protein-protein interactions in living systems and our improved understanding of them, protein-protein interactions are becoming an increasingly important part of drug discovery research projects. Drugs modulating protein-protein interactions are likely going to represent an increasing percentage of therapeutically active compounds.
Interakcije među proteinima nalaze se u osnovi kako fizioloških, tako i patoloških procesa, što ih čini važnim metama za razvoj novih lekova. U ovom radu su ukratko prikazane strukturne karakteristike kompleksa nastalih interakcijom proteina, osobine njihovih vezivnih površina i teorijske postavke na kojima se zasniva dizajn malih molekula modulatora proteinskih interakcija. Navedeno je nekoliko eksperimentalnih metoda primenjivih u razvoju organskih molekula koji deluju na protein-protein interakcije. Dosadašnji razvoj istraživanja u ovoj oblasti ilustrovan je kroz više primera uspešno dizajniranih modulatorskih jedinjenja. Zbog izuzetnog značaja u živim sistemima, a zahvaljujući sve boljem razumevanju protein-protein interakcija, one postaju sve važniji deo istraživačkih programa za razvoj novih lekova. Lekovi koji deluju kao modulatori proteinskih interakcija u budućnosti će verovatno predstavljati sve veći procenat terapijski aktivnih supstanci.
Keywords:
protein-protein interactions / hot-spot / drug design / protein-protein interakcije / hot-spot / dizajn lekova
Source:
Arhiv za farmaciju, 2011, 61, 5, 464-477
Publisher:
  • Savez farmaceutskih udruženja Srbije, Beograd
Funding / projects:
  • Computational design, synthesis and biological evaluation of new heterocyclic compounds as selective tumorogenesis inhibitors (RS-172009)

ISSN: 0004-1963

Scopus: 2-s2.0-84858983573
[ Google Scholar ]
Handle
https://hdl.handle.net/21.15107/rcub_farfar_1587
URI
https://farfar.pharmacy.bg.ac.rs/handle/123456789/1587
Collections
  • Radovi istraživača / Researchers’ publications
Institution/Community
Pharmacy
TY  - JOUR
AU  - Ranđelović, Jelena
AU  - Savić, Vladimir
PY  - 2011
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/1587
AB  - Protein-protein interactions form the basics of both physiological and pathological processes, which makes them important targets for drug discovery. Structural characteristics of protein complexes, features of their binding interfaces and theoretical foundations relevant to the design of small molecules modulators of protein interactions have been briefly described in this text. Several experimental methods applicable to the design of drugs acting on protein-protein interactions are listed. The research progress achieved so far is illustrated through several examples of successfully designed modulator molecules. Due to the extraordinary significance of protein-protein interactions in living systems and our improved understanding of them, protein-protein interactions are becoming an increasingly important part of drug discovery research projects. Drugs modulating protein-protein interactions are likely going to represent an increasing percentage of therapeutically active compounds.
AB  - Interakcije među proteinima nalaze se u osnovi kako fizioloških, tako i patoloških procesa, što ih čini važnim metama za razvoj novih lekova. U ovom radu su ukratko prikazane strukturne karakteristike kompleksa nastalih interakcijom proteina, osobine njihovih vezivnih površina i teorijske postavke na kojima se zasniva dizajn malih molekula modulatora proteinskih interakcija. Navedeno je nekoliko eksperimentalnih metoda primenjivih u razvoju organskih molekula koji deluju na protein-protein interakcije. Dosadašnji razvoj istraživanja u ovoj oblasti ilustrovan je kroz više primera uspešno dizajniranih modulatorskih jedinjenja. Zbog izuzetnog značaja u živim sistemima, a zahvaljujući sve boljem razumevanju protein-protein interakcija, one postaju sve važniji deo istraživačkih programa za razvoj novih lekova. Lekovi koji deluju kao modulatori proteinskih interakcija u budućnosti će verovatno predstavljati sve veći procenat terapijski aktivnih supstanci.
PB  - Savez farmaceutskih udruženja Srbije, Beograd
T2  - Arhiv za farmaciju
T1  - Protein-protein interactions in drug discovery
T1  - Protein-protein interakcije u razvoju novih lekova
VL  - 61
IS  - 5
SP  - 464
EP  - 477
UR  - https://hdl.handle.net/21.15107/rcub_farfar_1587
ER  - 
@article{
author = "Ranđelović, Jelena and Savić, Vladimir",
year = "2011",
abstract = "Protein-protein interactions form the basics of both physiological and pathological processes, which makes them important targets for drug discovery. Structural characteristics of protein complexes, features of their binding interfaces and theoretical foundations relevant to the design of small molecules modulators of protein interactions have been briefly described in this text. Several experimental methods applicable to the design of drugs acting on protein-protein interactions are listed. The research progress achieved so far is illustrated through several examples of successfully designed modulator molecules. Due to the extraordinary significance of protein-protein interactions in living systems and our improved understanding of them, protein-protein interactions are becoming an increasingly important part of drug discovery research projects. Drugs modulating protein-protein interactions are likely going to represent an increasing percentage of therapeutically active compounds., Interakcije među proteinima nalaze se u osnovi kako fizioloških, tako i patoloških procesa, što ih čini važnim metama za razvoj novih lekova. U ovom radu su ukratko prikazane strukturne karakteristike kompleksa nastalih interakcijom proteina, osobine njihovih vezivnih površina i teorijske postavke na kojima se zasniva dizajn malih molekula modulatora proteinskih interakcija. Navedeno je nekoliko eksperimentalnih metoda primenjivih u razvoju organskih molekula koji deluju na protein-protein interakcije. Dosadašnji razvoj istraživanja u ovoj oblasti ilustrovan je kroz više primera uspešno dizajniranih modulatorskih jedinjenja. Zbog izuzetnog značaja u živim sistemima, a zahvaljujući sve boljem razumevanju protein-protein interakcija, one postaju sve važniji deo istraživačkih programa za razvoj novih lekova. Lekovi koji deluju kao modulatori proteinskih interakcija u budućnosti će verovatno predstavljati sve veći procenat terapijski aktivnih supstanci.",
publisher = "Savez farmaceutskih udruženja Srbije, Beograd",
journal = "Arhiv za farmaciju",
title = "Protein-protein interactions in drug discovery, Protein-protein interakcije u razvoju novih lekova",
volume = "61",
number = "5",
pages = "464-477",
url = "https://hdl.handle.net/21.15107/rcub_farfar_1587"
}
Ranđelović, J.,& Savić, V.. (2011). Protein-protein interactions in drug discovery. in Arhiv za farmaciju
Savez farmaceutskih udruženja Srbije, Beograd., 61(5), 464-477.
https://hdl.handle.net/21.15107/rcub_farfar_1587
Ranđelović J, Savić V. Protein-protein interactions in drug discovery. in Arhiv za farmaciju. 2011;61(5):464-477.
https://hdl.handle.net/21.15107/rcub_farfar_1587 .
Ranđelović, Jelena, Savić, Vladimir, "Protein-protein interactions in drug discovery" in Arhiv za farmaciju, 61, no. 5 (2011):464-477,
https://hdl.handle.net/21.15107/rcub_farfar_1587 .

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