Elimination of angiotensin: Converting enzime inhibitors by peritoneal dialisate

Abstract

Angiotensin-converting enzyme (ACE) inhibitors are a significant group of drugs that are primarily used in the treatment of hypertension and congestive heart failure. Even though they belong to the same group of drugs and have similar efficacy, ACE inhibitors exhibit different pharmacological characteristics. The lipophilicity is one of the most important properties of biologically active substances. It influences their absorption, distribution, tissue penetration, action, elimination. In this paper, the elimination of ACE inhibitors by peritoneal dialisate in patients on peritoneal dialysis was investigated. The influence of ACE inhibitors' hydrophibicity in this way of elimination was discussed.

Inhibitori angiotenzin-konvertujućeg enzima (ACE inhibitori) najčešće su propisivani antihipertenzivni lekovi. Iako pripadaju istoj grupi lekova i pokazuju sličnu kliničku efikasnost, pojedini ACE inhibitori imaju različite farmakološke osobine, što može biti posledica njihovih različitih hemijskih karakteristika. Jedna od najznačajnijih osobina biološki aktivnih supstanci je njihova lipofilnost. Ona utiče na njihovu apsorpciju, raspodelu u tkiva, aktivnost, eliminaciju. U ovom radu proučavana je eliminacija ACE inhibitora fosinoprila i cilazaprila dijalizatom kod bolesnika na peritoneumskoj dijalizi i uticaj lipofilnosti na ovaj put njihove eliminacije. .