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Chromosome instability in Alzheimer's disease

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2011
1613.pdf (454.8Kb)
Authors
Potparević, Biljana
Živković, Lada
Plećaš-Solarović, Bosiljka
Bajić, Vladan
Article (Published version)
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Abstract
Alzheimer's disease (AD), as the most common form of dementia, has for many years attracted the attention of researchers around the world, primarily because of the problems of reliable diagnostic methods that could help in the early detection of this devastating disease. One of the important aspects of genetic research related to AD is the analysis of chromosome instability which includes: aneuploidies of different chromosomes, telomere shortening and the phenomenon of premature centromere division (PCD). The aim of this study was to describe specific biomarkers in different types of cells as potential parameters for the diagnosis of AD in order to promptly recognize pre-symptomatic stages and prevent the development of disease and/or slow down its progression.
Keywords:
Alzheimer's disease / chromosomes / aneuploidy / telomeres / centromere
Source:
Archives of Biological Sciences, 2011, 63, 3, 603-608
Publisher:
  • Srpsko biološko društvo, Beograd, i dr.
Projects:
  • Cell Cycle Aberrations and the Impact of Oxidative Stress in Neurodegenerative Processes and Malignant Transformation of the Cell (RS-173034)

DOI: 10.2298/ABS1103603P

ISSN: 0354-4664

WoS: 000294400500011

Scopus: 2-s2.0-79961186473
[ Google Scholar ]
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URI
http://farfar.pharmacy.bg.ac.rs/handle/123456789/1615
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  • Radovi istraživača / Researchers’ publications
Institution
Pharmacy

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