Annulation of isoquinoline and β-carboline using olefinic metathesis
Anelacije β-karbolina i izohinolina primenom reakcija olefinske metateze
Abstract
Isoquinoline and β-carboline derivatives are a large class of naturally occurring compounds. These compounds show variety of biological properties and as such they have been a subject of intensive research. Structural variations attracted attention from organic chemists as well and a number of synthesis for the preparation of these systems have been reported in the literature. Our strategy was based on annelation of the isoquinoline and β-carboline skeleton via ring closing metathesis reaction and further functionalization of the obtained product to more complex structures.
Izohinolinski i β-karbolinski skelet je prisutan u velikom broju prirodnih proizvoda, koji pokazuju širok spektar bioloških aktivnosti. Raznolikost njihovih struktura već godinama privlači pažnju organskih hemičara, pa su razvijene i brojne metode za sintezu ovih jedinjenja. U cilju razvoja alternativnog sintetskog pristupa, u našim laboratorijama proučavani su procesi anelacije izohinolinskog i β-karbolinskog skeleta zasnovani na reakciji olefinske metateze. Na ovaj način dobijene su strukture koje potencijalno mogu biti upotrebljene u sintezi kompleksnijih molekula, uključujući i neke klase prirodnih proizvoda zasnovanih na pomenutim heterocikličnim jedinjenjima.
Keywords:
isoquinoline / β-carboline / olefinic metathesis / izohinolin / β-karbolin / olefinska metatezaSource:
Arhiv za farmaciju, 2011, 61, 3, 267-278Publisher:
- Savez farmaceutskih udruženja Srbije, Beograd
Funding / projects:
Collections
Institution/Community
PharmacyTY - JOUR AU - Simić, Milena AU - Savić, Vladimir AU - Ranđelović, Jelena PY - 2011 UR - https://farfar.pharmacy.bg.ac.rs/handle/123456789/1618 AB - Isoquinoline and β-carboline derivatives are a large class of naturally occurring compounds. These compounds show variety of biological properties and as such they have been a subject of intensive research. Structural variations attracted attention from organic chemists as well and a number of synthesis for the preparation of these systems have been reported in the literature. Our strategy was based on annelation of the isoquinoline and β-carboline skeleton via ring closing metathesis reaction and further functionalization of the obtained product to more complex structures. AB - Izohinolinski i β-karbolinski skelet je prisutan u velikom broju prirodnih proizvoda, koji pokazuju širok spektar bioloških aktivnosti. Raznolikost njihovih struktura već godinama privlači pažnju organskih hemičara, pa su razvijene i brojne metode za sintezu ovih jedinjenja. U cilju razvoja alternativnog sintetskog pristupa, u našim laboratorijama proučavani su procesi anelacije izohinolinskog i β-karbolinskog skeleta zasnovani na reakciji olefinske metateze. Na ovaj način dobijene su strukture koje potencijalno mogu biti upotrebljene u sintezi kompleksnijih molekula, uključujući i neke klase prirodnih proizvoda zasnovanih na pomenutim heterocikličnim jedinjenjima. PB - Savez farmaceutskih udruženja Srbije, Beograd T2 - Arhiv za farmaciju T1 - Annulation of isoquinoline and β-carboline using olefinic metathesis T1 - Anelacije β-karbolina i izohinolina primenom reakcija olefinske metateze VL - 61 IS - 3 SP - 267 EP - 278 UR - https://hdl.handle.net/21.15107/rcub_farfar_1618 ER -
@article{ author = "Simić, Milena and Savić, Vladimir and Ranđelović, Jelena", year = "2011", abstract = "Isoquinoline and β-carboline derivatives are a large class of naturally occurring compounds. These compounds show variety of biological properties and as such they have been a subject of intensive research. Structural variations attracted attention from organic chemists as well and a number of synthesis for the preparation of these systems have been reported in the literature. Our strategy was based on annelation of the isoquinoline and β-carboline skeleton via ring closing metathesis reaction and further functionalization of the obtained product to more complex structures., Izohinolinski i β-karbolinski skelet je prisutan u velikom broju prirodnih proizvoda, koji pokazuju širok spektar bioloških aktivnosti. Raznolikost njihovih struktura već godinama privlači pažnju organskih hemičara, pa su razvijene i brojne metode za sintezu ovih jedinjenja. U cilju razvoja alternativnog sintetskog pristupa, u našim laboratorijama proučavani su procesi anelacije izohinolinskog i β-karbolinskog skeleta zasnovani na reakciji olefinske metateze. Na ovaj način dobijene su strukture koje potencijalno mogu biti upotrebljene u sintezi kompleksnijih molekula, uključujući i neke klase prirodnih proizvoda zasnovanih na pomenutim heterocikličnim jedinjenjima.", publisher = "Savez farmaceutskih udruženja Srbije, Beograd", journal = "Arhiv za farmaciju", title = "Annulation of isoquinoline and β-carboline using olefinic metathesis, Anelacije β-karbolina i izohinolina primenom reakcija olefinske metateze", volume = "61", number = "3", pages = "267-278", url = "https://hdl.handle.net/21.15107/rcub_farfar_1618" }
Simić, M., Savić, V.,& Ranđelović, J.. (2011). Annulation of isoquinoline and β-carboline using olefinic metathesis. in Arhiv za farmaciju Savez farmaceutskih udruženja Srbije, Beograd., 61(3), 267-278. https://hdl.handle.net/21.15107/rcub_farfar_1618
Simić M, Savić V, Ranđelović J. Annulation of isoquinoline and β-carboline using olefinic metathesis. in Arhiv za farmaciju. 2011;61(3):267-278. https://hdl.handle.net/21.15107/rcub_farfar_1618 .
Simić, Milena, Savić, Vladimir, Ranđelović, Jelena, "Annulation of isoquinoline and β-carboline using olefinic metathesis" in Arhiv za farmaciju, 61, no. 3 (2011):267-278, https://hdl.handle.net/21.15107/rcub_farfar_1618 .