Isoquinoline and β-carboline derivatives are a large class of naturally occurring compounds. These compounds show variety of biological properties and as such they have been a subject of intensive research. Structural variations attracted attention from organic chemists as well and a number of synthesis for the preparation of these systems have been reported in the literature. Our strategy was based on annelation of the isoquinoline and β-carboline skeleton via ring closing metathesis reaction and further functionalization of the obtained product to more complex structures.
Izohinolinski i β-karbolinski skelet je prisutan u velikom broju prirodnih proizvoda, koji pokazuju širok spektar bioloških aktivnosti. Raznolikost njihovih struktura već godinama privlači pažnju organskih hemičara, pa su razvijene i brojne metode za sintezu ovih jedinjenja. U cilju razvoja alternativnog sintetskog pristupa, u našim laboratorijama proučavani su procesi anelacije izohinolinskog i β-karbolinskog skeleta zasnovani na reakciji olefinske metateze. Na ovaj način dobijene su strukture koje potencijalno mogu biti upotrebljene u sintezi kompleksnijih molekula, uključujući i neke klase prirodnih proizvoda zasnovanih na pomenutim heterocikličnim jedinjenjima.
TY - JOUR
AU - Simić, Milena
AU - Savić, Vladimir
AU - Ranđelović, Jelena
PY - 2011
UR - https://farfar.pharmacy.bg.ac.rs/handle/123456789/1618
AB - Isoquinoline and β-carboline derivatives are a large class of naturally occurring compounds. These compounds show variety of biological properties and as such they have been a subject of intensive research. Structural variations attracted attention from organic chemists as well and a number of synthesis for the preparation of these systems have been reported in the literature. Our strategy was based on annelation of the isoquinoline and β-carboline skeleton via ring closing metathesis reaction and further functionalization of the obtained product to more complex structures.
AB - Izohinolinski i β-karbolinski skelet je prisutan u velikom broju prirodnih proizvoda, koji pokazuju širok spektar bioloških aktivnosti. Raznolikost njihovih struktura već godinama privlači pažnju organskih hemičara, pa su razvijene i brojne metode za sintezu ovih jedinjenja. U cilju razvoja alternativnog sintetskog pristupa, u našim laboratorijama proučavani su procesi anelacije izohinolinskog i β-karbolinskog skeleta zasnovani na reakciji olefinske metateze. Na ovaj način dobijene su strukture koje potencijalno mogu biti upotrebljene u sintezi kompleksnijih molekula, uključujući i neke klase prirodnih proizvoda zasnovanih na pomenutim heterocikličnim jedinjenjima.
PB - Savez farmaceutskih udruženja Srbije, Beograd
T2 - Arhiv za farmaciju
T1 - Annulation of isoquinoline and β-carboline using olefinic metathesis
T1 - Anelacije β-karbolina i izohinolina primenom reakcija olefinske metateze
VL - 61
IS - 3
SP - 267
EP - 278
UR - https://hdl.handle.net/21.15107/rcub_farfar_1618
ER -
@article{
author = "Simić, Milena and Savić, Vladimir and Ranđelović, Jelena",
year = "2011",
abstract = "Isoquinoline and β-carboline derivatives are a large class of naturally occurring compounds. These compounds show variety of biological properties and as such they have been a subject of intensive research. Structural variations attracted attention from organic chemists as well and a number of synthesis for the preparation of these systems have been reported in the literature. Our strategy was based on annelation of the isoquinoline and β-carboline skeleton via ring closing metathesis reaction and further functionalization of the obtained product to more complex structures., Izohinolinski i β-karbolinski skelet je prisutan u velikom broju prirodnih proizvoda, koji pokazuju širok spektar bioloških aktivnosti. Raznolikost njihovih struktura već godinama privlači pažnju organskih hemičara, pa su razvijene i brojne metode za sintezu ovih jedinjenja. U cilju razvoja alternativnog sintetskog pristupa, u našim laboratorijama proučavani su procesi anelacije izohinolinskog i β-karbolinskog skeleta zasnovani na reakciji olefinske metateze. Na ovaj način dobijene su strukture koje potencijalno mogu biti upotrebljene u sintezi kompleksnijih molekula, uključujući i neke klase prirodnih proizvoda zasnovanih na pomenutim heterocikličnim jedinjenjima.",
publisher = "Savez farmaceutskih udruženja Srbije, Beograd",
journal = "Arhiv za farmaciju",
title = "Annulation of isoquinoline and β-carboline using olefinic metathesis, Anelacije β-karbolina i izohinolina primenom reakcija olefinske metateze",
volume = "61",
number = "3",
pages = "267-278",
url = "https://hdl.handle.net/21.15107/rcub_farfar_1618"
}
Simić, M., Savić, V.,& Ranđelović, J.. (2011). Annulation of isoquinoline and β-carboline using olefinic metathesis. in Arhiv za farmaciju
Savez farmaceutskih udruženja Srbije, Beograd., 61(3), 267-278.
https://hdl.handle.net/21.15107/rcub_farfar_1618
Simić M, Savić V, Ranđelović J. Annulation of isoquinoline and β-carboline using olefinic metathesis. in Arhiv za farmaciju. 2011;61(3):267-278.
https://hdl.handle.net/21.15107/rcub_farfar_1618 .
Simić, Milena, Savić, Vladimir, Ranđelović, Jelena, "Annulation of isoquinoline and β-carboline using olefinic metathesis" in Arhiv za farmaciju, 61, no. 3 (2011):267-278,
https://hdl.handle.net/21.15107/rcub_farfar_1618 .
