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dc.creatorTadić, Ivana
dc.creatorVujasinović-Stupar, Nada
dc.creatorTasić, Ljiljana
dc.creatorStevanović, Dejan
dc.creatorDimić, Aleksandar
dc.creatorStamenković, Bojana
dc.creatorStojanović, Sonja
dc.creatorMilenković, Sasa
dc.date.accessioned2019-09-02T11:27:01Z
dc.date.available2019-09-02T11:27:01Z
dc.date.issued2012
dc.identifier.issn1477-7525
dc.identifier.urihttp://farfar.pharmacy.bg.ac.rs/handle/123456789/1622
dc.description.abstractBackground: Vertebral fractures could lead to reduced physical, social and mental functioning, and loss of personal independence. Therefore, during the treatment of osteoporosis, it has become necessary to examine the changes in everyday functioning, well-being and health related quality of life (HRQOL). To that effect, this study aims to translate, culturally adapt, and validate the Serbian version of Quality of Life Questionnaire of the European Foundation for Osteoporosis (QUALEFFO-41) for patients with vertebral fractures. Methods: Nine female patients with osteoporosis participated in the pre-validation study. A validation, case-control study included two groups of female patients: one that consisted of 50 female patients with osteoporosis, and with at least one vertebral fracture, and another one that consisted of 50 control patients with osteoporosis but without fractures. They completed the QUALEFFO-41 and the EuroQol group questionnaire with five dimensions (EQ-5D) twice within a month. The validation study examined internal consistency, concurrent validity, test-retest reliability, sensitivity and specificity. Results: During the pre-validation study, three of the items in the QUALEFFO-41 were slightly changed. Afterwards, during the validation study, the statistically significant differences (adjusted for: age, duration of menopause, current employment and marital status) in the mean values of all domains and total scores between the groups were noted. For the case group, the internal consistency of the QUALEFFO-41 domains and of total questionnaire was above 0.70. The test-retest reliability was tested by the intraclass correlation coefficients (ICC) that were in range 0.87 - 0.96 for the case, and 0.15 - 0.83 for the control group. Correlations between the total scores of the QUALEFFO-41 and the EQ-5D health state value, for both groups were negative and statistically significant (r = -0.78, p lt 0.001 and r = -0.73, p lt 0.001, respectively). The QUALEFFO-41 had a better prediction of the value of HRQOL of cases compared to the generic questionnaire EQ-5D (the AUC difference was 0.099, p = 0.013). Conclusions: The Serbian QUALEFFO-41 version is reliable, valid, sensitive and predictive for examinations of HRQOL in patients with prevalent vertebral fractures and can be used in further studies.en
dc.publisherBiomed Central Ltd, London
dc.relationMerck Sharp and Dohme, representative office in Serbia
dc.rightsopenAccess
dc.sourceHealth and Quality of Life Outcomes
dc.subjectOsteoporosisen
dc.subjectValidationen
dc.subjectQuality of lifeen
dc.titleValidation of the osteoporosis quality of life questionnaire QUALEFFO-41 for the Serbian populationen
dc.typearticle
dc.rights.licenseBY
dcterms.abstractВујасиновић-Ступар, Нада; Димић, Aлександар; Стаменковић, Бојана; Миленковић, Саса; Стојановић, Соња; Стевановић, Дејан; Тадић, Ивана; Тасић, Љиљана;
dc.citation.volume10
dc.citation.other10: -
dc.citation.rankM21
dc.identifier.wos000308024700001
dc.identifier.doi10.1186/1477-7525-10-74
dc.identifier.pmid22709379
dc.identifier.scopus2-s2.0-84862253278
dc.identifier.fulltexthttp://farfar.pharmacy.bg.ac.rs//bitstream/id/466/1620.pdf
dc.identifier.rcubconv_2676
dc.type.versionpublishedVersion


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