Objective: The aim of the study was to investigate renal functional reserve (RFR) and to assess its relationship with serum cystatin C and blood pressure in children with apparently normal congenital solitary functioning kidney (SFK). Material and methods: RFR was obtained from the difference of endogenous creatinine clearance (CrCs) before and after a meat-free oral protein load (OPL) in the patients who were pre-treated with cimetidine. Serum cystatin C and urinary protein excretion were determined before and after OPL Results: Among 22 patients (13 boys), aged 9.5 +/- 4.3years, 72.7% had increased serum cystatin C, and 54.5% had decreased RFR. Following OPL, CrCs and urine creatinine increased, while serum creatinine and cystatin C remained unchanged. The multiple regression analysis demonstrated that cystatin C could predict more than 90% of RFR variability. Conclusion: Half of the patients with apparently normal SFK had decreased RFR. Serum cystatin C is one of the best predictors... of RFR.
Keywords:
Glomerular hyperfiltration / Unilateral renal agenesis / Multicystic dysplastic kidney / Renal function / Cystatin C
TY - JOUR
AU - Peco-Antić, Amira
AU - Paripović, Dušan
AU - Kotur-Stevuljević, Jelena
AU - Stefanović, Aleksandra
AU - Scekić, Gordana
AU - Miloševski-Lomić, Gordana
PY - 2012
UR - https://farfar.pharmacy.bg.ac.rs/handle/123456789/1625
AB - Objective: The aim of the study was to investigate renal functional reserve (RFR) and to assess its relationship with serum cystatin C and blood pressure in children with apparently normal congenital solitary functioning kidney (SFK). Material and methods: RFR was obtained from the difference of endogenous creatinine clearance (CrCs) before and after a meat-free oral protein load (OPL) in the patients who were pre-treated with cimetidine. Serum cystatin C and urinary protein excretion were determined before and after OPL Results: Among 22 patients (13 boys), aged 9.5 +/- 4.3years, 72.7% had increased serum cystatin C, and 54.5% had decreased RFR. Following OPL, CrCs and urine creatinine increased, while serum creatinine and cystatin C remained unchanged. The multiple regression analysis demonstrated that cystatin C could predict more than 90% of RFR variability. Conclusion: Half of the patients with apparently normal SFK had decreased RFR. Serum cystatin C is one of the best predictors of RFR.
PB - Pergamon-Elsevier Science Ltd, Oxford
T2 - Clinical Biochemistry
T1 - Renal functional reserve in children with apparently normal congenital solitary functioning kidney
VL - 45
IS - 15
SP - 1173
EP - 1177
DO - 10.1016/j.clinbiochem.2012.06.018
ER -
@article{
author = "Peco-Antić, Amira and Paripović, Dušan and Kotur-Stevuljević, Jelena and Stefanović, Aleksandra and Scekić, Gordana and Miloševski-Lomić, Gordana",
year = "2012",
abstract = "Objective: The aim of the study was to investigate renal functional reserve (RFR) and to assess its relationship with serum cystatin C and blood pressure in children with apparently normal congenital solitary functioning kidney (SFK). Material and methods: RFR was obtained from the difference of endogenous creatinine clearance (CrCs) before and after a meat-free oral protein load (OPL) in the patients who were pre-treated with cimetidine. Serum cystatin C and urinary protein excretion were determined before and after OPL Results: Among 22 patients (13 boys), aged 9.5 +/- 4.3years, 72.7% had increased serum cystatin C, and 54.5% had decreased RFR. Following OPL, CrCs and urine creatinine increased, while serum creatinine and cystatin C remained unchanged. The multiple regression analysis demonstrated that cystatin C could predict more than 90% of RFR variability. Conclusion: Half of the patients with apparently normal SFK had decreased RFR. Serum cystatin C is one of the best predictors of RFR.",
publisher = "Pergamon-Elsevier Science Ltd, Oxford",
journal = "Clinical Biochemistry",
title = "Renal functional reserve in children with apparently normal congenital solitary functioning kidney",
volume = "45",
number = "15",
pages = "1173-1177",
doi = "10.1016/j.clinbiochem.2012.06.018"
}
Peco-Antić, A., Paripović, D., Kotur-Stevuljević, J., Stefanović, A., Scekić, G.,& Miloševski-Lomić, G.. (2012). Renal functional reserve in children with apparently normal congenital solitary functioning kidney. in Clinical Biochemistry
Pergamon-Elsevier Science Ltd, Oxford., 45(15), 1173-1177.
https://doi.org/10.1016/j.clinbiochem.2012.06.018
Peco-Antić A, Paripović D, Kotur-Stevuljević J, Stefanović A, Scekić G, Miloševski-Lomić G. Renal functional reserve in children with apparently normal congenital solitary functioning kidney. in Clinical Biochemistry. 2012;45(15):1173-1177.
doi:10.1016/j.clinbiochem.2012.06.018 .
Peco-Antić, Amira, Paripović, Dušan, Kotur-Stevuljević, Jelena, Stefanović, Aleksandra, Scekić, Gordana, Miloševski-Lomić, Gordana, "Renal functional reserve in children with apparently normal congenital solitary functioning kidney" in Clinical Biochemistry, 45, no. 15 (2012):1173-1177,
https://doi.org/10.1016/j.clinbiochem.2012.06.018 . .
