Renal functional reserve in children with apparently normal congenital solitary functioning kidney
Само за регистроване кориснике
2012
Аутори
Peco-Antić, AmiraParipović, Dušan

Kotur-Stevuljević, Jelena

Stefanović, Aleksandra

Scekić, Gordana
Miloševski-Lomić, Gordana
Чланак у часопису (Објављена верзија)

Метаподаци
Приказ свих података о документуАпстракт
Objective: The aim of the study was to investigate renal functional reserve (RFR) and to assess its relationship with serum cystatin C and blood pressure in children with apparently normal congenital solitary functioning kidney (SFK). Material and methods: RFR was obtained from the difference of endogenous creatinine clearance (CrCs) before and after a meat-free oral protein load (OPL) in the patients who were pre-treated with cimetidine. Serum cystatin C and urinary protein excretion were determined before and after OPL Results: Among 22 patients (13 boys), aged 9.5 +/- 4.3years, 72.7% had increased serum cystatin C, and 54.5% had decreased RFR. Following OPL, CrCs and urine creatinine increased, while serum creatinine and cystatin C remained unchanged. The multiple regression analysis demonstrated that cystatin C could predict more than 90% of RFR variability. Conclusion: Half of the patients with apparently normal SFK had decreased RFR. Serum cystatin C is one of the best predictors... of RFR.
Кључне речи:
Glomerular hyperfiltration / Unilateral renal agenesis / Multicystic dysplastic kidney / Renal function / Cystatin CИзвор:
Clinical Biochemistry, 2012, 45, 15, 1173-1177Издавач:
- Pergamon-Elsevier Science Ltd, Oxford
Финансирање / пројекти:
- Улога биомаркера у раном откривању оштећења бубрега и праћењу терапијског одговора код деце (RS-175079)
DOI: 10.1016/j.clinbiochem.2012.06.018
ISSN: 0009-9120
PubMed: 22732526
WoS: 000309631000010
Scopus: 2-s2.0-84866290056
Институција/група
PharmacyTY - JOUR AU - Peco-Antić, Amira AU - Paripović, Dušan AU - Kotur-Stevuljević, Jelena AU - Stefanović, Aleksandra AU - Scekić, Gordana AU - Miloševski-Lomić, Gordana PY - 2012 UR - https://farfar.pharmacy.bg.ac.rs/handle/123456789/1625 AB - Objective: The aim of the study was to investigate renal functional reserve (RFR) and to assess its relationship with serum cystatin C and blood pressure in children with apparently normal congenital solitary functioning kidney (SFK). Material and methods: RFR was obtained from the difference of endogenous creatinine clearance (CrCs) before and after a meat-free oral protein load (OPL) in the patients who were pre-treated with cimetidine. Serum cystatin C and urinary protein excretion were determined before and after OPL Results: Among 22 patients (13 boys), aged 9.5 +/- 4.3years, 72.7% had increased serum cystatin C, and 54.5% had decreased RFR. Following OPL, CrCs and urine creatinine increased, while serum creatinine and cystatin C remained unchanged. The multiple regression analysis demonstrated that cystatin C could predict more than 90% of RFR variability. Conclusion: Half of the patients with apparently normal SFK had decreased RFR. Serum cystatin C is one of the best predictors of RFR. PB - Pergamon-Elsevier Science Ltd, Oxford T2 - Clinical Biochemistry T1 - Renal functional reserve in children with apparently normal congenital solitary functioning kidney VL - 45 IS - 15 SP - 1173 EP - 1177 DO - 10.1016/j.clinbiochem.2012.06.018 ER -
@article{ author = "Peco-Antić, Amira and Paripović, Dušan and Kotur-Stevuljević, Jelena and Stefanović, Aleksandra and Scekić, Gordana and Miloševski-Lomić, Gordana", year = "2012", abstract = "Objective: The aim of the study was to investigate renal functional reserve (RFR) and to assess its relationship with serum cystatin C and blood pressure in children with apparently normal congenital solitary functioning kidney (SFK). Material and methods: RFR was obtained from the difference of endogenous creatinine clearance (CrCs) before and after a meat-free oral protein load (OPL) in the patients who were pre-treated with cimetidine. Serum cystatin C and urinary protein excretion were determined before and after OPL Results: Among 22 patients (13 boys), aged 9.5 +/- 4.3years, 72.7% had increased serum cystatin C, and 54.5% had decreased RFR. Following OPL, CrCs and urine creatinine increased, while serum creatinine and cystatin C remained unchanged. The multiple regression analysis demonstrated that cystatin C could predict more than 90% of RFR variability. Conclusion: Half of the patients with apparently normal SFK had decreased RFR. Serum cystatin C is one of the best predictors of RFR.", publisher = "Pergamon-Elsevier Science Ltd, Oxford", journal = "Clinical Biochemistry", title = "Renal functional reserve in children with apparently normal congenital solitary functioning kidney", volume = "45", number = "15", pages = "1173-1177", doi = "10.1016/j.clinbiochem.2012.06.018" }
Peco-Antić, A., Paripović, D., Kotur-Stevuljević, J., Stefanović, A., Scekić, G.,& Miloševski-Lomić, G.. (2012). Renal functional reserve in children with apparently normal congenital solitary functioning kidney. in Clinical Biochemistry Pergamon-Elsevier Science Ltd, Oxford., 45(15), 1173-1177. https://doi.org/10.1016/j.clinbiochem.2012.06.018
Peco-Antić A, Paripović D, Kotur-Stevuljević J, Stefanović A, Scekić G, Miloševski-Lomić G. Renal functional reserve in children with apparently normal congenital solitary functioning kidney. in Clinical Biochemistry. 2012;45(15):1173-1177. doi:10.1016/j.clinbiochem.2012.06.018 .
Peco-Antić, Amira, Paripović, Dušan, Kotur-Stevuljević, Jelena, Stefanović, Aleksandra, Scekić, Gordana, Miloševski-Lomić, Gordana, "Renal functional reserve in children with apparently normal congenital solitary functioning kidney" in Clinical Biochemistry, 45, no. 15 (2012):1173-1177, https://doi.org/10.1016/j.clinbiochem.2012.06.018 . .