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Renal functional reserve in children with apparently normal congenital solitary functioning kidney
dc.creator | Peco-Antić, Amira | |
dc.creator | Paripović, Dušan | |
dc.creator | Kotur-Stevuljević, Jelena | |
dc.creator | Stefanović, Aleksandra | |
dc.creator | Scekić, Gordana | |
dc.creator | Miloševski-Lomić, Gordana | |
dc.date.accessioned | 2019-09-02T11:27:06Z | |
dc.date.available | 2019-09-02T11:27:06Z | |
dc.date.issued | 2012 | |
dc.identifier.issn | 0009-9120 | |
dc.identifier.uri | https://farfar.pharmacy.bg.ac.rs/handle/123456789/1625 | |
dc.description.abstract | Objective: The aim of the study was to investigate renal functional reserve (RFR) and to assess its relationship with serum cystatin C and blood pressure in children with apparently normal congenital solitary functioning kidney (SFK). Material and methods: RFR was obtained from the difference of endogenous creatinine clearance (CrCs) before and after a meat-free oral protein load (OPL) in the patients who were pre-treated with cimetidine. Serum cystatin C and urinary protein excretion were determined before and after OPL Results: Among 22 patients (13 boys), aged 9.5 +/- 4.3years, 72.7% had increased serum cystatin C, and 54.5% had decreased RFR. Following OPL, CrCs and urine creatinine increased, while serum creatinine and cystatin C remained unchanged. The multiple regression analysis demonstrated that cystatin C could predict more than 90% of RFR variability. Conclusion: Half of the patients with apparently normal SFK had decreased RFR. Serum cystatin C is one of the best predictors of RFR. | en |
dc.publisher | Pergamon-Elsevier Science Ltd, Oxford | |
dc.relation | info:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/175079/RS// | |
dc.rights | restrictedAccess | |
dc.source | Clinical Biochemistry | |
dc.subject | Glomerular hyperfiltration | en |
dc.subject | Unilateral renal agenesis | en |
dc.subject | Multicystic dysplastic kidney | en |
dc.subject | Renal function | en |
dc.subject | Cystatin C | en |
dc.title | Renal functional reserve in children with apparently normal congenital solitary functioning kidney | en |
dc.type | article | |
dc.rights.license | ARR | |
dcterms.abstract | Милошевски-Ломић, Гордана; Котур-Стевуљевић, Јелена; Пецо-Aнтић, Aмира; Стефановић, Aлександра; Париповић, Душан; Сцекић, Гордана; | |
dc.citation.volume | 45 | |
dc.citation.issue | 15 | |
dc.citation.spage | 1173 | |
dc.citation.epage | 1177 | |
dc.citation.other | 45(15): 1173-1177 | |
dc.citation.rank | M21 | |
dc.identifier.wos | 000309631000010 | |
dc.identifier.doi | 10.1016/j.clinbiochem.2012.06.018 | |
dc.identifier.pmid | 22732526 | |
dc.identifier.scopus | 2-s2.0-84866290056 | |
dc.type.version | publishedVersion |