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Combined effects of cadmium and decabrominated diphenyl ether on thyroid hormones in rats

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2012
1625.pdf (75.44Kb)
Authors
Ćurčić, Marijana
Janković, Saša
Jaćević, Vesna
Stanković, Sanja
Vučinić, Slavica
Durgo, Ksenija
Bulat, Zorica
Antonijević, Biljana
Article (Published version)
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Abstract
The aim of this study was to see how a mixture of cadmium (Cd) and decabrominated diphenyl ether (BDE209) affect thyroid function, namely thyroid-stimulating hormone (TSH), thyroxin (T4), free thyroxin (FT4), triiodothyronin (T3), and free triiodothyronin (FT3) in Wistar rats (eight per group) receiving either a single substance or their combination by gavage for 28 days. Three groups were receiving Cd alone in the doses of 2.5 mg kg(-1), 7.5 mg kg(-1), or 15 mg kg(-1) b. w. a day, three groups were receiving BDE209 in the doses of 1000 mg kg(-1), 2000 mg kg(-1), or 4000 mg kg(-1) b. w. a day, while nine groups were receiving different mixtures of Cd and BDE209 in these doses (3x3 design). The results have indicated that the Cd+BDE209 mixtures more potently disrupt thyroid hormone homeostasis than would be expected from these chemicals alone.
Keywords:
BDE209 / Cd / thyroid-stimulating hormone / thyroxin / triiodothyronin
Source:
Arhiv za higijenu rada i toksikologiju - Archives of Industrial Hygiene and Toxicology, 2012, 63, 3, 255-262
Publisher:
  • Inst Medical Research & Occupational Health, Zagreb
Projects:
  • Improvement and development of hygienic and technological procedures in production of animal originating foodstuffs with the aim of producing high-quality and safe products competetive on the global market (RS-46009)

DOI: 10.2478/10004-1254-63-2012-2179

ISSN: 0004-1254

PubMed: 23152375

WoS: 000309641400002

Scopus: 2-s2.0-84875761723
[ Google Scholar ]
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URI
http://farfar.pharmacy.bg.ac.rs/handle/123456789/1627
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  • Radovi istraživača / Researchers’ publications
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Pharmacy

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