Combined effects of cadmium and decabrominated diphenyl ether on thyroid hormones in rats

2012
Authors
Ćurčić, Marijana
Janković, Saša
Jaćević, Vesna

Stanković, Sanja

Vučinić, Slavica

Durgo, Ksenija
Bulat, Zorica

Antonijević, Biljana

Article (Published version)

Metadata
Show full item recordAbstract
The aim of this study was to see how a mixture of cadmium (Cd) and decabrominated diphenyl ether (BDE209) affect thyroid function, namely thyroid-stimulating hormone (TSH), thyroxin (T4), free thyroxin (FT4), triiodothyronin (T3), and free triiodothyronin (FT3) in Wistar rats (eight per group) receiving either a single substance or their combination by gavage for 28 days. Three groups were receiving Cd alone in the doses of 2.5 mg kg(-1), 7.5 mg kg(-1), or 15 mg kg(-1) b. w. a day, three groups were receiving BDE209 in the doses of 1000 mg kg(-1), 2000 mg kg(-1), or 4000 mg kg(-1) b. w. a day, while nine groups were receiving different mixtures of Cd and BDE209 in these doses (3x3 design). The results have indicated that the Cd+BDE209 mixtures more potently disrupt thyroid hormone homeostasis than would be expected from these chemicals alone.
Keywords:
BDE209 / Cd / thyroid-stimulating hormone / thyroxin / triiodothyroninSource:
Arhiv za higijenu rada i toksikologiju - Archives of Industrial Hygiene and Toxicology, 2012, 63, 3, 255-262Publisher:
- Inst Medical Research & Occupational Health, Zagreb
Projects:
DOI: 10.2478/10004-1254-63-2012-2179
ISSN: 0004-1254
PubMed: 23152375