The aim of this study was to see how a mixture of cadmium (Cd) and decabrominated diphenyl ether (BDE209) affect thyroid function, namely thyroid-stimulating hormone (TSH), thyroxin (T4), free thyroxin (FT4), triiodothyronin (T3), and free triiodothyronin (FT3) in Wistar rats (eight per group) receiving either a single substance or their combination by gavage for 28 days. Three groups were receiving Cd alone in the doses of 2.5 mg kg(-1), 7.5 mg kg(-1), or 15 mg kg(-1) b. w. a day, three groups were receiving BDE209 in the doses of 1000 mg kg(-1), 2000 mg kg(-1), or 4000 mg kg(-1) b. w. a day, while nine groups were receiving different mixtures of Cd and BDE209 in these doses (3x3 design). The results have indicated that the Cd+BDE209 mixtures more potently disrupt thyroid hormone homeostasis than would be expected from these chemicals alone.
Keywords:
BDE209 / Cd / thyroid-stimulating hormone / thyroxin / triiodothyronin
Source:
Arhiv za higijenu rada i toksikologiju - Archives of Industrial Hygiene and Toxicology, 2012, 63, 3, 255-262
Publisher:
Inst Medical Research & Occupational Health, Zagreb
TY - JOUR
AU - Ćurčić, Marijana
AU - Janković, Saša
AU - Jaćević, Vesna
AU - Stanković, Sanja
AU - Vučinić, Slavica
AU - Durgo, Ksenija
AU - Bulat, Zorica
AU - Antonijević, Biljana
PY - 2012
UR - http://farfar.pharmacy.bg.ac.rs/handle/123456789/1627
AB - The aim of this study was to see how a mixture of cadmium (Cd) and decabrominated diphenyl ether (BDE209) affect thyroid function, namely thyroid-stimulating hormone (TSH), thyroxin (T4), free thyroxin (FT4), triiodothyronin (T3), and free triiodothyronin (FT3) in Wistar rats (eight per group) receiving either a single substance or their combination by gavage for 28 days. Three groups were receiving Cd alone in the doses of 2.5 mg kg(-1), 7.5 mg kg(-1), or 15 mg kg(-1) b. w. a day, three groups were receiving BDE209 in the doses of 1000 mg kg(-1), 2000 mg kg(-1), or 4000 mg kg(-1) b. w. a day, while nine groups were receiving different mixtures of Cd and BDE209 in these doses (3x3 design). The results have indicated that the Cd+BDE209 mixtures more potently disrupt thyroid hormone homeostasis than would be expected from these chemicals alone.
PB - Inst Medical Research & Occupational Health, Zagreb
T2 - Arhiv za higijenu rada i toksikologiju - Archives of Industrial Hygiene and Toxicology
T1 - Combined effects of cadmium and decabrominated diphenyl ether on thyroid hormones in rats
VL - 63
IS - 3
SP - 255
EP - 262
DO - 10.2478/10004-1254-63-2012-2179
ER -
@article{
author = "Ćurčić, Marijana and Janković, Saša and Jaćević, Vesna and Stanković, Sanja and Vučinić, Slavica and Durgo, Ksenija and Bulat, Zorica and Antonijević, Biljana",
year = "2012",
url = "http://farfar.pharmacy.bg.ac.rs/handle/123456789/1627",
abstract = "The aim of this study was to see how a mixture of cadmium (Cd) and decabrominated diphenyl ether (BDE209) affect thyroid function, namely thyroid-stimulating hormone (TSH), thyroxin (T4), free thyroxin (FT4), triiodothyronin (T3), and free triiodothyronin (FT3) in Wistar rats (eight per group) receiving either a single substance or their combination by gavage for 28 days. Three groups were receiving Cd alone in the doses of 2.5 mg kg(-1), 7.5 mg kg(-1), or 15 mg kg(-1) b. w. a day, three groups were receiving BDE209 in the doses of 1000 mg kg(-1), 2000 mg kg(-1), or 4000 mg kg(-1) b. w. a day, while nine groups were receiving different mixtures of Cd and BDE209 in these doses (3x3 design). The results have indicated that the Cd+BDE209 mixtures more potently disrupt thyroid hormone homeostasis than would be expected from these chemicals alone.",
publisher = "Inst Medical Research & Occupational Health, Zagreb",
journal = "Arhiv za higijenu rada i toksikologiju - Archives of Industrial Hygiene and Toxicology",
title = "Combined effects of cadmium and decabrominated diphenyl ether on thyroid hormones in rats",
volume = "63",
number = "3",
pages = "255-262",
doi = "10.2478/10004-1254-63-2012-2179"
}
Ćurčić, M., Janković, S., Jaćević, V., Stanković, S., Vučinić, S., Durgo, K., Bulat, Z.,& Antonijević, B. (2012). Combined effects of cadmium and decabrominated diphenyl ether on thyroid hormones in rats.
Arhiv za higijenu rada i toksikologiju - Archives of Industrial Hygiene and Toxicology
Inst Medical Research & Occupational Health, Zagreb., 63(3), 255-262.
https://doi.org/10.2478/10004-1254-63-2012-2179
Ćurčić M, Janković S, Jaćević V, Stanković S, Vučinić S, Durgo K, Bulat Z, Antonijević B. Combined effects of cadmium and decabrominated diphenyl ether on thyroid hormones in rats. Arhiv za higijenu rada i toksikologiju - Archives of Industrial Hygiene and Toxicology. 2012;63(3):255-262
Ćurčić Marijana, Janković Saša, Jaćević Vesna, Stanković Sanja, Vučinić Slavica, Durgo Ksenija, Bulat Zorica, Antonijević Biljana, "Combined effects of cadmium and decabrominated diphenyl ether on thyroid hormones in rats" Arhiv za higijenu rada i toksikologiju - Archives of Industrial Hygiene and Toxicology, 63, no. 3 (2012):255-262,
https://doi.org/10.2478/10004-1254-63-2012-2179 .
