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Combined effects of cadmium and decabrominated diphenyl ether on thyroid hormones in rats
dc.creator | Ćurčić, Marijana | |
dc.creator | Janković, Saša | |
dc.creator | Jaćević, Vesna | |
dc.creator | Stanković, Sanja | |
dc.creator | Vučinić, Slavica | |
dc.creator | Durgo, Ksenija | |
dc.creator | Bulat, Zorica | |
dc.creator | Antonijević, Biljana | |
dc.date.accessioned | 2019-09-02T11:27:07Z | |
dc.date.available | 2019-09-02T11:27:07Z | |
dc.date.issued | 2012 | |
dc.identifier.issn | 0004-1254 | |
dc.identifier.uri | https://farfar.pharmacy.bg.ac.rs/handle/123456789/1627 | |
dc.description.abstract | The aim of this study was to see how a mixture of cadmium (Cd) and decabrominated diphenyl ether (BDE209) affect thyroid function, namely thyroid-stimulating hormone (TSH), thyroxin (T4), free thyroxin (FT4), triiodothyronin (T3), and free triiodothyronin (FT3) in Wistar rats (eight per group) receiving either a single substance or their combination by gavage for 28 days. Three groups were receiving Cd alone in the doses of 2.5 mg kg(-1), 7.5 mg kg(-1), or 15 mg kg(-1) b. w. a day, three groups were receiving BDE209 in the doses of 1000 mg kg(-1), 2000 mg kg(-1), or 4000 mg kg(-1) b. w. a day, while nine groups were receiving different mixtures of Cd and BDE209 in these doses (3x3 design). The results have indicated that the Cd+BDE209 mixtures more potently disrupt thyroid hormone homeostasis than would be expected from these chemicals alone. | en |
dc.publisher | Inst Medical Research & Occupational Health, Zagreb | |
dc.relation | info:eu-repo/grantAgreement/MESTD/Integrated and Interdisciplinary Research (IIR or III)/46009/RS// | |
dc.rights | openAccess | |
dc.source | Arhiv za higijenu rada i toksikologiju - Archives of Industrial Hygiene and Toxicology | |
dc.subject | BDE209 | en |
dc.subject | Cd | en |
dc.subject | thyroid-stimulating hormone | en |
dc.subject | thyroxin | en |
dc.subject | triiodothyronin | en |
dc.title | Combined effects of cadmium and decabrominated diphenyl ether on thyroid hormones in rats | en |
dc.type | article | |
dc.rights.license | ARR | |
dcterms.abstract | Јаћевић, Весна; Вучинић, Славица; Дурго, Ксенија; Булат, Зорица; Станковић, Сања; Aнтонијевић, Биљана; Јанковић, Саша; Ћурчић, Маријана; | |
dc.citation.volume | 63 | |
dc.citation.issue | 3 | |
dc.citation.spage | 255 | |
dc.citation.epage | 262 | |
dc.citation.other | 63(3): 255-262 | |
dc.citation.rank | M23 | |
dc.identifier.wos | 000309641400002 | |
dc.identifier.doi | 10.2478/10004-1254-63-2012-2179 | |
dc.identifier.pmid | 23152375 | |
dc.identifier.scopus | 2-s2.0-84875761723 | |
dc.identifier.fulltext | https://farfar.pharmacy.bg.ac.rs//bitstream/id/470/1625.pdf | |
dc.type.version | publishedVersion |