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Deterioration of Thromboses in Primary Antiphospholipid Syndrome: TNF-alpha and Anti-Annexin A5 Antibodies
dc.creator | Becarević, Mirjana | |
dc.creator | Ignjatović, Svetlana | |
dc.creator | Majkić-Singh, Nada | |
dc.date.accessioned | 2019-09-02T11:27:14Z | |
dc.date.available | 2019-09-02T11:27:14Z | |
dc.date.issued | 2012 | |
dc.identifier.issn | 1433-6510 | |
dc.identifier.uri | https://farfar.pharmacy.bg.ac.rs/handle/123456789/1632 | |
dc.description.abstract | Background: To investigate the association between clinical and serological features of patients with primary antiphospholipid syndrome (PAPS) and TNF-alpha, interleukin 6 (IL-6), and soluble IL-2 receptor (sIL-2R). Methods: ELISA was used for measurement of antibodies (Abs) and TNF-alpha, while IL-6 and sIL-2R were measured by chemiluminescence. Results: PAPS patients with pulmonary emboli showed positive correlation between IgM isotype of anti-annexin A5 antibodies and TNF-alpha (r = 0.894, p = 0.041) and IgM class of anticardiolipin antibodies and sIL-2R (r = 0.900, p = 0.037). In PAPS with cerebrovascular insults, positive correlation was noticed between TNF-alpha and IgG isotype of anticardiolipin (r = 0.624, p = 0.040) and anti-annexinA5 Abs (r = 0.768, p = 0.006). Conclusions: Isotype analysis of antiphospholipid and anti-annexin A5 Abs and investigation of their association with TNF-alpha is important for differentiation of PAPS patients that are prone to further deterioration of arterial and venous thromboses. (Clin. Lab. 2012;58:1079-1084. DOI: 10.7754/Clin.Lab.2012.110918) | en |
dc.publisher | Clin Lab Publ, Heidelberg | |
dc.relation | info:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/175036/RS// | |
dc.rights | restrictedAccess | |
dc.source | Clinical Laboratory | |
dc.subject | Anti-annexin A5 antibodies | en |
dc.subject | interleukin 6 | en |
dc.subject | primary antiphospholipid syndrome | en |
dc.subject | soluble interleukin 2 receptor | en |
dc.subject | TNF-alpha | en |
dc.title | Deterioration of Thromboses in Primary Antiphospholipid Syndrome: TNF-alpha and Anti-Annexin A5 Antibodies | en |
dc.type | article | |
dc.rights.license | ARR | |
dcterms.abstract | Бецаревић, Мирјана; Игњатовић, Светлана; Мајкић-Сингх, Нада; | |
dc.citation.volume | 58 | |
dc.citation.issue | 9-10 | |
dc.citation.spage | 1079 | |
dc.citation.epage | 1084 | |
dc.citation.other | 58(9-10): 1079-1084 | |
dc.citation.rank | M23 | |
dc.identifier.wos | 000310560200027 | |
dc.identifier.doi | 10.7754/Clin.Lab.2012.110918 | |
dc.identifier.pmid | 23163128 | |
dc.identifier.scopus | 2-s2.0-84868572676 | |
dc.type.version | publishedVersion |
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