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dc.creatorTopić, Aleksandra
dc.creatorStankovic, Marija
dc.creatorDivac-Rankov, Aleksandra
dc.creatorPetrović-Stanojević, Nataša
dc.creatorMitić-Milikić, Marija
dc.creatorNagorni-Obradović, Ljudmila
dc.creatorRadojković, Dragica
dc.date.accessioned2019-09-02T11:27:18Z
dc.date.available2019-09-02T11:27:18Z
dc.date.issued2012
dc.identifier.issn1945-0265
dc.identifier.urihttps://farfar.pharmacy.bg.ac.rs/handle/123456789/1633
dc.description.abstractAim: Alpha-1-antitrypsin (A1AT) is the main inhibitor of neutrophil elastase, and severe alpha-1-antitrypsin deficiency (A1ATD) is a genetic risk factor for early-onset emphysema. Despite the relatively high prevalence of A1ATD, this condition is frequently underdiagnosed. Our aim was to determine the distribution of the A1ATD phenotypes/alleles in patients with lung diseases as well as in the Serbian population. Methods: The study included the adults with chronic obstructive pulmonary disease (COPD) (n = 348), asthma (n = 71), and bronchiectasis (n = 35); the control was 1435 healthy blood donors. The A1ATD variants were identified by isoelectric focusing or polymerase chain reaction-mediated site-directed mutagenesis. Results: PiMZ heterozygotes, PiZZ homozygotes, and Z allele carriers are associated with significantly higher risk of developing COPD than healthy individuals (odds ratios 3.43, 42.42, and 5.49 respectively). The calculated prevalence of PiZZ, PiMZ, and PiSZ was higher in patients with COPD (1:202, 1:8, and 1:1243) than in the Serbian population (1: 5519, 1: 38, and 1:5519). Conclusion: The high prevalence of A1ATD phenotypes/allele in our population has confirmed the necessity of screening for A1ATD in patients with COPD. On the other hand, on the basis of the estimated number of those with A1ATD among the COPD patients, it is possible to assess the diagnostic efficiency of A1ATD in the Serbian population.en
dc.publisherMary Ann Liebert Inc, New Rochelle
dc.relationinfo:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/173008/RS//
dc.rightsopenAccess
dc.sourceGenetic Testing and Molecular Biomarkers
dc.titleAlpha-1-Antitrypsin Deficiency in Serbian Adults with Lung Diseasesen
dc.typearticle
dc.rights.licenseARR
dcterms.abstractРадојковић, Драгица; Дивац-Ранков, Aлександра; Станковиц, Марија; Топиц, Aлександра; Петровић-Станојевић, Наташа; Нагорни-Обрадовић, Људмила; Митић-Миликић, Марија;
dc.citation.volume16
dc.citation.issue11
dc.citation.spage1282
dc.citation.epage1286
dc.citation.other16(11): 1282-1286
dc.citation.rankM23
dc.identifier.wos000310573800006
dc.identifier.doi10.1089/gtmb.2012.0152
dc.identifier.pmid22971141
dc.identifier.scopus2-s2.0-84868029755
dc.identifier.fulltexthttps://farfar.pharmacy.bg.ac.rs//bitstream/id/475/1631.pdf
dc.type.versionpublishedVersion


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